High blood PUFA "a specific feature of severe COVID-19 pneumonia"

[haidut]

The evidence for PUFA being a crucial pathological factor in yet another disease is probably not surprising to my readers. The reason I like this study is that since COVID-19 is still (unfortunately) the main topic of the day in most Western countries, a study discussing PUFA in a COVID-19 context may get a lot more attention than something like a PUFA-diabetes or a PUFA-cancer study. In nothing else, it may stimulate a lot of people to Google for "polyunsaturated fats" or "PUFA" and thus become acquainted with the most ubiquitous poison of our time. So, again, if PUFA is a major issue in COVID-19, and especially in the associated pneumonia (which is what is responsible for most hospitalizations/deaths) then anti-lipolytic interventions such as aspirin, niacinamide, vitamin E, sugar, pregnenolone/progesterone may be cheap and widely available OTC substances that can save countless lives if adopted more liberally by the healthcare system. And if Big Pharma won't use those due to lack of profit potential, then doctors should at least consider patented niacin derivatives such as Acipimox (which has the same effects as niacin(amide) but costs 100 times more).

High plasma concentration of non-esterified polyunsaturated fatty acids is a specific feature of severe COVID-19 pneumonia - Scientific Reports

"...COVID-19 pneumonia has specific features and outcomes that suggests a unique immunopathogenesis. Severe forms of COVID-19 appear to be more frequent in obese patients, but an association with metabolic disorders is not established. Here, we focused on lipoprotein metabolism in patients hospitalized for severe pneumonia, depending on COVID-19 status. Thirty-four non-COVID-19 and 27 COVID-19 patients with severe pneumonia were enrolled. Most of them required intensive care. Plasma lipid levels, lipoprotein metabolism, and clinical and biological (including plasma cytokines) features were assessed. Despite similar initial metabolic comorbidities and respiratory severity, COVID-19 patients displayed a lower acute phase response but higher plasmatic concentrations of non-esterified fatty acids (NEFAs). NEFA profiling was characterised by higher level of polyunsaturated NEFAs (mainly linoleic and arachidonic acids) in COVID-19 patients. Multivariable analysis showed that among severe pneumonia, COVID-19-associated pneumonia was associated with higher NEFAs, lower apolipoprotein E and lower high-density lipoprotein cholesterol concentrations, independently of body mass index, sequential organ failure (SOFA) score, and C-reactive protein levels. NEFAs and PUFAs concentrations were negatively correlated with the number of ventilator-free days. Among hospitalized patients with severe pneumonia, COVID-19 is independently associated with higher NEFAs (mainly linoleic and arachidonic acids) and lower apolipoprotein E and HDL concentrations. These features might act as mediators in COVID-19 pathogenesis and emerge as new therapeutic targets. Further investigations are required to define the role of NEFAs in the pathogenesis and the dysregulated immune response associated with COVID-19."

 

[Drareg]

Meanwhile hospital food is still soaked in PUFA, even some of the protein drinks they give to the elderly and cancer patients contain PUFA, someone on here highlighted recently? that being fed via a tube contains huge amounts of seed oils as the fat source.

 

[Lollipop2]

@eugenics4dumies

 

[Lollipop2]

anti-lipolytic interventions such as aspirin, niacinamide, vitamin E, sugar, pregnenolone/progesterone

@eugenics4dumies this list is particularly helpful for substances that heal/help the liver.

 

[eugenics4dumies]

@eugenics4dumies this list is particularly helpful for substances that heal/help the liver.

Thank you!

 

[haidut]

Meanwhile hospital food is still soaked in PUFA, even some of the protein drinks they give to the elderly and cancer patients contain PUFA, someone on here highlighted recently? that being fed via a tube contains huge amounts of seed oils as the fat source.

Yeah, I think it is fair to say that to this day, no officially sanctioned hospital intervention for COVID-19 (except the antibiotics for pneumonia) is helping the patient in any way, and many are making things much worse for the patient. The PUFA in hospital food is probably the most nefarious as nobody is even thinking about the food and its composition when the patient is in poor condition and 5 doctors are running around deciding on what poison (e.g. remdesivir) to administer.
There is also the so-called "total parenteral nutrition" (IV nutrition bags for people who cannot eat normally). It contains oils exclusively of seed origin in order to keep costs low. Another argument is that it keeps the contents liquid as SFA would make it solid or at least not flowing well-enough for an IV route. Of course, the fact that olive oil or MCT resolve that problem is never mentioned, so it is quite obvious cost is the main decision factor on what oils to include. Needless to say, unlike regular food where a patient can request say yogurt, fruit, milk, cheese, etc if they don't like the PUFA-laden hospital food, with the IV bag the patient is stuck with whatever the doctor decides should be pumped into the patient and even if the doctor was open-minded and would listen to concerns about the IV bag, if the patient cannot physically eat and IV route is the only option, there are really no other IV nutritional formulations that do not contain PUFA.
I think the bag also often has emulsifiers such as the notorious carrageenan or the gums (carob bean gum, acacia gum, etc), or pectin and/or other GMO modified starch. Silica, talc, lactate, etc are also pretty much a given, though they probably vary from brand to brand. Finally, the vitamin/mineral mix is the same allergenic crap sold in stores and when administered IV the effects are even stronger allergies/inflammation.

 

[Rafe]

PUFA accumulation is probably the the fact that explains why conventionally “healthy” persons also sometimes have a bad time with covid & some die.

They avoid meat, saturated & trans fats, dairy. They want low total cholesterol. They substitute high fiber, raw vegetables, nut milks, flax seed, seed oils, chia seeds, quinoa, fish oil, salmon, whole grains, beans & go out & run marathons or other endurance exercise, then drink 2 quarts of plain water a day. Compulsively. Their docs tell them their TSH of 2 & cholesterol of 130 is great. They Rx radio-tracer & other traumatic diagnostic tests. Oh yeah, & SSRIs & sleep meds.

Then the “healthy” people wonder why they get osteoporosis, cancer, muscle wasting, anxiety, energy crashes, & degenerative decline. And sometimes die of covid. “Out of nowhere.”

Even infant formula relies mainly on whey protein, soy/safflower/sunflower oils, & vitamins including iron.

So it’s really no big mystery.

 

[Rafe]

Meantime, supercentenarians say they definitely are not doing any of those “healthy” things.

Once you see this it’s hard to understand how anyone ever buys the public health & cultural health messaging.

 

[Jam]

From September 2020:

Mortality From Coronavirus Disease 2019 Increases With Unsaturated Fat and May Be Reduced by Early Calcium and Albumin Supplementation

www.ncbi.nlm.nih.gov

 

[Perry Staltic]

And sometimes die of covid. “Out of nowhere

No one dies of "covid" out of nowhere. They all die in ICUs pumped full of toxic drugs and hooked up to vents or ECMO which destroy their health.

 

[aliml]

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[Rafe]

No one dies of "covid" out of nowhere. They all die in ICUs pumped full of toxic drugs and hooked up to vents or ECMO which destroy their health.

Agree. That’s why it’s in quotes.

 

[Lollipop2]

No one dies of "covid" out of nowhere. They all die in ICUs pumped full of toxic drugs and hooked up to vents or ECMO which destroy their health.

For which the hospital earns 100,000 k from that death.

 

[Regina]

For which the hospital earns 100,000 k from that death.

ya mean "earns" with a wink

 

[Lollipop2]

ya mean "earns" with a wink

Literally from Biden’s Covid funding - remember they “earn” 40,000 if they can get you on a vent ?

 

[yerrag]

There is also the so-called "total parenteral nutrition" (IV nutrition bags for people who cannot eat normally). It contains oils exclusively of seed origin in order to keep costs low. Another argument is that it keeps the contents liquid as SFA would make it solid or at least not flowing well-enough for an IV route. Of course, the fact that olive oil or MCT resolve that problem is never mentioned, so it is quite obvious cost is the main decision factor on what oils to include. Needless to say, unlike regular food where a patient can request say yogurt, fruit, milk, cheese, etc if they don't like the PUFA-laden hospital food, with the IV bag the patient is stuck with whatever the doctor decides should be pumped into the patient and even if the doctor was open-minded and would listen to concerns about the IV bag, if the patient cannot physically eat and IV route is the only option, there are really no other IV nutritional formulations that do not contain PUFA.

You're being too kind.

Olive oil or MCT isn't going to break the bank for the parenteral nutrition companies.

The real reason is these oils won't contribute to longer hospital stays and more return visits and increased usage of interventions such as prescription drugs. In short, it runs counter to the de facto mission statement of the medical system.

You see this kind of shenanigan also in how doctors treat patients of hypertension. First, the bait and switch where some high priced doctor ($3000 -6000/consultation, tests not included) would tell patients his philosophy is to wean his patients off bp medication (many people don't want bp medication, and doctors that say "no bp medication" know this is a good market to charge high) but there would be a sort of fine print where he considers hypertension to be caused by genetics. So after a few consultations and recommendations, and lifestyle changes, such as working out and walking a lot, meditation, and a whole panoply of supplements, and with the doctor recommending more PUFA intake (because tons of research says it's really good for you), the patient would be told it is in his genes, and that there is no choice but to take bp prescription drugs. The patient would be out a couple of $10k and would just resign himself to his genetics and console himself saying that at least he tried and the science says he is helpless. He would never know whether or not the drug he takes is making him worse off or not.

Why? Because it is too troublesome to get the permission of the PCP each time he wants to have a blood test taken. So, if your health takes a down swing, you'd never know and the next time your heart, or liver, or kidneys shows a problem, it would be too far down the road to make the connection. After all, the only metric looked at with hypertension is the blood pressure. People think that when blood pressure goes down, all is better but they don't know if the lower perfusion of blood to the vital organs is going to cause lower metabolism or higher inflammation and tissue destruction.

I'm digressing but my point is that PUFA as sold by the AHA is a big factor why doctors continue to make us sicker while they simulaneously treat us. Well, they never cure us. They only make us worse off.

 

[PolishSun]

but people really believe in the propaganda about PUFA or other medicines ("poisons"). Probably more information is needed on that, I personally found Ray Peat through some other forum. But it happened after more than 10 years of googling on health topics.

 

[Amazoniac]

- Rationale for using new lipid emulsions in parenteral nutrition and a review of the trials performed in adults "terminoleic acid"

"The concern about potential harm, based mainly on the notion that n-6 PUFA might be ‘proinflammatory, immunosuppressive and pro-coagulatory’, has led to the development of alternative lipid emulsions for parenteral applications."​

A claim of allergy to soybean oil could exclude most total parenteral formulas, but then there's the risk of the 1% pushing the one made exclusively of fish oil, pacific haidut and yerrag.

- Systematic Review of Hypersensitivity to Parenteral Nutrition "soybead"
- Hypersensitivity reaction to components of parenteral nutrition in pediatrics

Since a reason for the inclusion of fats is to prevent the Education For All deficiency, it's tough to find a lipidic product that's safe because they will contain a source of these unsaturated fats.

- Low-Fat, High-Carbohydrate Parenteral Nutrition (PN) May Potentially Reverse Liver Disease in Long-Term PN-Dependent Infants

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The yellow solutions in transparent bags under hospital lighting is also a great idea.