due to a serious iatrogenic condition i must take intranasally a drug called PILOCARPINE that is a cholinesterase inhibitor - consequently it raises acetylcholine.
How bad can it be. i find conflicting literature on this
Many in vivo studies (easy to find online) claims it SIGNIFICANTLY lowers prolactin. just ONE IN VITRO study claims it increases prolactine.
Ref;
One study where it says it increases prolactin, in vitro
Also many other studies claim pilocarpine stopped rats from initiating sexual activity
thoughts?
How bad can it be. i find conflicting literature on this
Many in vivo studies (easy to find online) claims it SIGNIFICANTLY lowers prolactin. just ONE IN VITRO study claims it increases prolactine.
Ref;
Inhibition of prolactin secretion and synthesis by dopamine, noradrenaline and pilocarpine in cultured rat pituitary tumour cells - PubMed
Clonal strains of rat pituitary tumour cells (GH3-cells) synthesize and secrete prolactin into a chemically defined culture medium. Short time treatment (0.5-2 hrs) of cell cultures with noradrenaline (10(-3) M) and dopamine (10(-3 M) reduced the spontaneous secretion of prolactin by 50% and...
pubmed.ncbi.nlm.nih.gov
Inhibition by cholinergic agonists of the prolactin release induced by morphine - PubMed
The cholinergic agonists, pilocarpine, physostigmine and nicotine, inhibited the prolactin release induced by morphine in male rats in vivo. Pilocarpine also inhibited the release of prolactin induced by beta-endorphin or metoclopramide without affecting the basal and haloperidol-stimulated...
pubmed.ncbi.nlm.nih.gov
Evidence for Adrenergic Mediation of Cholinergic Inhibition of Prolactin Release
Pilocarpine, a cholinergic agonist, significantly reduced the high levels of serum prolactin in estrogen-primed male rats and in female rats on the late afterno
academic.oup.com
Serotonin and acetylcholine affect the release of prolactin and growth hormone from pituitary glands of domestic fowl in vitro in the presence of hypothalamic tissue
Abstract. Anterior pituitary glands from broiler fowl were incubated alone or with hypothalamic tissue in medium containing either serotonin or serotoninergic drugs, acetylcholine or cholinergic drugs, and the release of prolactin (Prl) and growth hormone (GH) measured by homologous...
eje.bioscientifica.com
THE STIMULATION OF CANINE PROSTATIC SECRETION BY PILOCARPINE
The stimulation of prostatic secretion by pilocarpine was studied in unanesthetized, castrated, testosterone-treated dogs with surgically prepared fistulas which allowed the collection of prostatic fluid uncontaminated by urine. In these dogs the intravenous injection of pilocarpine stimulated...
jpet.aspetjournals.org
The inhibition of CYP enzymes in mouse and human liver by pilocarpine | British Pharmacological Society
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