Help, What Is The Stability Of Pregnenolone In Liquid?

Feb 26, 2018
I just looked around but was not able to find anything helpful so I am asking here for help.

I have 100mg capsules of pregnanolone but I want to experiment with taking lower doses throughout the day. My idea was to break a capsule or two open and distribute in a gallon of orange juice or a gallon of water and then drink this throughout several days.

Ideally I want to store a solution like this just for a week and not have to worry about it losing potency. I cannot find any helpful info on the stability and half life etc in water and at different ph and different temperatures.

If you happen to have this data to share of can direct me somewhere that I can find this please let me know!

Thank you!


Thread starter
Feb 26, 2018
I'm also open to other carriers than juice or water, e.g. alcohol or oil. What is the stability in the various mediums? e.g. If I were to add some pregnenolone powder from these caps in to olive oil, for how long will the potency remain stable at room temperature??


Nov 23, 2013
Hmmm, I'm not sure about at room temperature but I'd guess dissolving it in vitamin E as your solvent would help it remain potent for several months. You could then mix the dissolved pregnenolone/vitamin E with your oil of choice (coconut, olive oil, cocoa butter, mct). With MCT or olive oil you could probably use a dropper bottle.
I've been making vaginal suppositories with dhea, pregnenolone (pansterone) and progesterone in vitamin E which I mix in melted cocoa butter. The steroids are already dissolved for me though. I put this in small candy molds to harden and store them in the freezer. I don't see why this wouldn't work just as well for general topical or oral use.
Just some thoughts...


Thread starter
Feb 26, 2018
Thanks blossom. Vitamin E does make sense to me too since it would likely act as a preservative. I was hoping to hear of some other soluble mediums aside from oil, it would be nice if there was a simple method to get it to dissolve with water + alcohol or some vinegar for instance. I'd like to ideally have it all premixed and ready to drink over the course of a few days (in a jug in the fridge), rather than have to remember to keep squeezing out tincture drops 5 times a day.
Similar threads
Thread starter Title Forum Replies Date
K Post-keto help/encouragement request Diet 5
H Help searching for medical journals on Mrna vaccine Ask For Help or Advice 0
F Whats the top things to help out with the gout? Ask For Help or Advice 9
johnwester130 Help me in making liquid acetazolamide Pharmaceutical Drugs 3
D Need to help my girlfriend suffering from SSRI use Cortisol, Serotonin, Histamine 6
Y Help in finding Covid studies on respirators with only oxygen vs carbogen (5% CO2). CO2, Bag Breathing 9
Rinse & rePeat INGREDIENTS CHECKER - Help Please! Additives 54
M Took methylene blue first time and don’t feel good. Panic attacks pls help Ask For Help or Advice 28
emac Anyone else ever had a 'Pityriasis Rosea' breakout all over torso? pls help!.. Skin 8
H Job offer - need someone to help formulate Peat-friendly supplements The Ray Peat Forum Lounge 46
SonOfEurope Help for recovering from laxative abuse. Digestion 3
D Need help finding studies showing serotonin is dopamine antagonist/lowers dopamine Cortisol, Serotonin, Histamine 10
haidut PUFA required for periodontal disease, aspirin may help Scientific Studies 12
Sefton10 Help interpreting mother’s blood work Blood Work, Labs 17
SatoshiPufamoto Toenail Fungas! Help! Ask For Help or Advice 15
J Vaccine Mandate Help California Supplements, Pharmaceutical Drugs 4
N COVID Long Hauler for 7 months, need help Viruses, Parasites, Fungus, Vaccines 122
Summer Need help forgetting or overcoming a fear of something Ask For Help or Advice 33
P Lab Results but without explanation, pls help! Labs 3
Nfinkelstein Need help interpreting labs Ask For Help or Advice 1
Nfinkelstein Need help interpreting labs Blood Work, Labs 0
PleaseDoo21 Excessive saliva production, need desperate help Ask For Help or Advice 8
koshko Progesterone low blood pressure 80/40. Help! Ask For Help or Advice 2
D Low PTH, low hair tissue calcium, and constantly craving high calcium foods. Help. Ask For Help or Advice 10
P Help Please. I met with a lawyer to sue our school board. Ask For Help or Advice 23
rawmeat Forced Vaccine as Athlete (Help mitigate the injection) Ray Peat Topics 47
limitless77 Can SSRIs help someone who is depressed Cortisol, Serotonin, Histamine 49
G Help with cycles + belly fat Female Issues 6
U Tight Budget - Help Me Choose Digestion 5
G I am a tired b****. Please help Mental Issues 48
Pina How to help prevent Covid-19 injections (viral vector gene therapy) for Children Vaccines 48
C Help, High cholesterol and triglycerides Cholesterol 5
B Need help with some serious medical issues after from clomid and hcg blood pressure going crazy Ask For Help or Advice 0
C Need help understanding estrogen issues Ask For Help or Advice 6
D Covid-19, neurological issues, and Coffee: Need Help Coffee 19
R COVID Vaccine Mandate Help Ask For Help or Advice 27
C Help with DUTCH results- low estrogen, low progesterone but normal cortisol? Blood Work, Labs 4
L Creatine might help fighting Covid Scientific Studies 1
jpgio Does anyone know of any natural solutions to help reduce intracranial pressure? (Idiopathic Intracranial Hypertension, Pseudotumour Cerebri) Supplements 12
miquelangeles Please help interpret lab results (female) Labs 9
Alex Jaramillo Help me get rid of covid Health 22
N Please help me understand - PFS and Diabetes Type 2 symptoms Metabolism 5
sibyloftherhine Help with understanding Pfizer report: Accumulation of vaccine in ovaries Vaccines 13
Asya_D Please help me to find a recent study on covid and Vaccinated VS Unvaccinated by Cleveland Clinic Vaccines 5
koshko Help with Tyromix Ask For Help or Advice 10
A So you've just eaten out an unhealthy meal with PUFA - what supplements to help counteract? Ask For Help or Advice 24
ddjd NEED HELP. My partner wants the vaccine and is breastfeeding our 3 week old baby Ask For Help or Advice 125
K Supplements that help with anxiety? Mental Issues 19
unsubscribed Possible help with interpretation Blood Work, Labs 10
A GF threatening to get the double snake bite - help needed on material to show Vaccines 86

Similar threads