Hello,
In Bulgaria, it is not easy to find a functional medicine doctor, so we partially treat ourselves.
For many months I have been reading very intensively (over 10,000 pages) everything on the forum and outside it because I really want to help my wife (44 years old, 63 kg, 160 cm tall, smoker - 7-10 cigarettes a day, does not drink alcohol, heart pulse when idle approx.70, temperature 36.8C/98.24F) to discover and solve her Hashimoto's, anxiety, memory, focus and love issues. This problem leads us to divorce. I think heavy metals and insulin resistance are the trigger for the condition. I sincerely hope to receive your comments.
From the community here and across Internet I was able to figure out that something is really wrong.
I would like to get your advice, comments or criticism if the way we are going is fine as my wife is very scared of the supplements she started taking at my insistence because I am not a doctor.
During pregnancy in 2007, she increased her weight from 51 kg to 85+. Two years later, she managed to lose 20 kg.
Symptoms before diagnosis (2014): panic attacks and several types of SSRIs (Zoloft was on max dosage) for 1 year. No energy, depressions, emotional problems and low libido.
Diagnosis with proven Hashimoto's disease (hypothyroidism) with antibodies over 1000+, insulin resistance and estrogen dominance.
Date of diagnosis: 2010 (no treatment were prescribed except Selenium). Lots of endocrinologist were visited since then.
In 2020, the last endocrinologist prescribed treatment: ACCU-THYROX (T4).
In 2020, the following mutations were discovered through genetic lab exam:
- MTHFR A1298C type (A/C), rs1801131,
- MTHFR C677T type (C/T), rs1801133,
- COMT type (G/A), rs4680,
- DRD2 - Dopamine receptor type (G/G), rs18000497,
- VDR type (T/C), rs731236,
- MAOA type (G/T), rs6323,
- MTRR type (A/G) rs1801394,
My wife can't methylate Vitamins B by genetic.
* No covid-19 vaccine.
As of today she is not taking any SSRI's but continue to have mild symptoms of anxiety, low level of stress, mood issues, lack of happiness, complete lack of motivation, very low or no libido.
Since 2020 until now, she takes T4 (88 mcg) at the morning 30 minutes before food/coffee, and since 2022, she is taking T3 (6 mcg in total) twice a day 3mcg around 11:30 and 3mcg 16:30. Not sure if dosage is OK.
In addition, to hormones - Seekinghealth Adeno B12, Seekinghealth Folinic Acid Lozenge (1360 mcg DFE), Utrogestan 100 mg (progesterone) from 14 to 28 day of the cycle 3 times a day applied on the skin and Pregnenolon ( from 5 to 15 day of the cycle), because of the very low level of cortisol and ACTH.
Very often eating, especially sugars. Trying to avoid PUFA and gluten when possible.
Whatever amount of food she is taking is blowing her stomach.
Despite taking T3 hormone, energy wanes up to 2 hours after taking T3. Some sleep is needed in the early afternoon. This greatly interferes the work and general condition.
After 2 years in fitness, 3 times a week and different diets with no results in weight.
The main goals defined:
1. To improve liver function;
2. To fix leaky gut;
3. To optimize the kidneys and adrenal glands;
4. To detoxify heavy metals without leaving residues in the brain which will then not be able to cross the BBB;
5. Solution in regards of motivation and libido;
At the beginning of December 2022, we did a lot of lab tests including for heavy metals.
On 12/23/2022 she started supplements for the first time in her life on my advice. She is very worried taking them as already explained.
At first I didn't think about Taurine but on the advice of @haidut I included it. There is almost a 2 kg drop in weight, less need to sleep in the afternoon and less appetite than before the supplements. Still anxiety and no libido (probably from berberine??).
Current supplements list (with estimated duration) :
- Swanson Berberine - 500 mg - 3 times per day (1 year) ;
- NOW Taurine - 1000 mg - 3 times per day (30 days) ;
- GNC Vitamin D - 400 IU - 3 times per day (30 days) ;
- Holland&Barrett Black Cumin Seed Oil - 500 mg - 1 time per day (30 days) ;
- NOW Glutathione - 500 mg - 1 time per day (30 days) ;
- Thytrophin PMG - 3 times per day (1 year) ;
- NOW Choline & inositol - 1 time per day (30 days) ;
- Probiotic Fortify Optima, 100 billion, 15 Probiotic strains, 63 billion CFU - 1 per day (15 days);
- Double Wood TUDCA - 1 per day (60 days);
- Vitamin D+K2 5000 per day but not every day for every other month;
- CandidFree - 1 time per day for 1 month;
Planning to change current supplements with the following once a month have passed:
- All active forms of vitamin B in a certain scheme with a gradual increase for 1 month;
- IdeaLabs Vitamin E - 1 month;
- NOW Rhadiola - from time to time if required;
- NOW DOPA Mucuna - every other day;
- NOW Betaine HCl - each heavy meal;
- Manganese Chelate - for 1 month;
- Wobenzym PS or another system enzymes - for 1 month;
- NMN - for 1 month;
- NOW Silymarin Milk Thistle - 2 months;
- Quicksilver Scientific Liver Sauce - for 1 month
- Kirkman 5-MTHF ([6S]-5-Methyltetrahydrofolate) 5 mg OR MethylPro B-Complex + 5 mg L-Methylfolate
Supplements we're not sure yet if we should start taking them:
- Solgar L-tyrosine + GABA for one month but not together with NOW DOPA Mucuna;
Detox Plan: Quicksilver IMD or BioRay NDF Plus or QuickSilver Quad.
So, guys, what are you thinking about:
1. Do you think that doses, ingredients, frequency are OK or do you think we should change something?
2. What do you thing about simultaneous intake of these supplements?
3. What do you think about the detox plan and the option to gradually increase the T3 to 6 mcg 4 times a day? And the T4?
P.S. We know that Dr. Peat does not believe that antibodies really exist the way they've been explained by modern medicine.
In Bulgaria, it is not easy to find a functional medicine doctor, so we partially treat ourselves.
For many months I have been reading very intensively (over 10,000 pages) everything on the forum and outside it because I really want to help my wife (44 years old, 63 kg, 160 cm tall, smoker - 7-10 cigarettes a day, does not drink alcohol, heart pulse when idle approx.70, temperature 36.8C/98.24F) to discover and solve her Hashimoto's, anxiety, memory, focus and love issues. This problem leads us to divorce. I think heavy metals and insulin resistance are the trigger for the condition. I sincerely hope to receive your comments.
From the community here and across Internet I was able to figure out that something is really wrong.
I would like to get your advice, comments or criticism if the way we are going is fine as my wife is very scared of the supplements she started taking at my insistence because I am not a doctor.
During pregnancy in 2007, she increased her weight from 51 kg to 85+. Two years later, she managed to lose 20 kg.
Symptoms before diagnosis (2014): panic attacks and several types of SSRIs (Zoloft was on max dosage) for 1 year. No energy, depressions, emotional problems and low libido.
Diagnosis with proven Hashimoto's disease (hypothyroidism) with antibodies over 1000+, insulin resistance and estrogen dominance.
Date of diagnosis: 2010 (no treatment were prescribed except Selenium). Lots of endocrinologist were visited since then.
In 2020, the last endocrinologist prescribed treatment: ACCU-THYROX (T4).
In 2020, the following mutations were discovered through genetic lab exam:
- MTHFR A1298C type (A/C), rs1801131,
- MTHFR C677T type (C/T), rs1801133,
- COMT type (G/A), rs4680,
- DRD2 - Dopamine receptor type (G/G), rs18000497,
- VDR type (T/C), rs731236,
- MAOA type (G/T), rs6323,
- MTRR type (A/G) rs1801394,
My wife can't methylate Vitamins B by genetic.
* No covid-19 vaccine.
As of today she is not taking any SSRI's but continue to have mild symptoms of anxiety, low level of stress, mood issues, lack of happiness, complete lack of motivation, very low or no libido.
Since 2020 until now, she takes T4 (88 mcg) at the morning 30 minutes before food/coffee, and since 2022, she is taking T3 (6 mcg in total) twice a day 3mcg around 11:30 and 3mcg 16:30. Not sure if dosage is OK.
In addition, to hormones - Seekinghealth Adeno B12, Seekinghealth Folinic Acid Lozenge (1360 mcg DFE), Utrogestan 100 mg (progesterone) from 14 to 28 day of the cycle 3 times a day applied on the skin and Pregnenolon ( from 5 to 15 day of the cycle), because of the very low level of cortisol and ACTH.
Very often eating, especially sugars. Trying to avoid PUFA and gluten when possible.
Whatever amount of food she is taking is blowing her stomach.
Despite taking T3 hormone, energy wanes up to 2 hours after taking T3. Some sleep is needed in the early afternoon. This greatly interferes the work and general condition.
After 2 years in fitness, 3 times a week and different diets with no results in weight.
The main goals defined:
1. To improve liver function;
2. To fix leaky gut;
3. To optimize the kidneys and adrenal glands;
4. To detoxify heavy metals without leaving residues in the brain which will then not be able to cross the BBB;
5. Solution in regards of motivation and libido;
At the beginning of December 2022, we did a lot of lab tests including for heavy metals.
On 12/23/2022 she started supplements for the first time in her life on my advice. She is very worried taking them as already explained.
At first I didn't think about Taurine but on the advice of @haidut I included it. There is almost a 2 kg drop in weight, less need to sleep in the afternoon and less appetite than before the supplements. Still anxiety and no libido (probably from berberine??).
Current supplements list (with estimated duration) :
- Swanson Berberine - 500 mg - 3 times per day (1 year) ;
- NOW Taurine - 1000 mg - 3 times per day (30 days) ;
- GNC Vitamin D - 400 IU - 3 times per day (30 days) ;
- Holland&Barrett Black Cumin Seed Oil - 500 mg - 1 time per day (30 days) ;
- NOW Glutathione - 500 mg - 1 time per day (30 days) ;
- Thytrophin PMG - 3 times per day (1 year) ;
- NOW Choline & inositol - 1 time per day (30 days) ;
- Probiotic Fortify Optima, 100 billion, 15 Probiotic strains, 63 billion CFU - 1 per day (15 days);
- Double Wood TUDCA - 1 per day (60 days);
- Vitamin D+K2 5000 per day but not every day for every other month;
- CandidFree - 1 time per day for 1 month;
Planning to change current supplements with the following once a month have passed:
- All active forms of vitamin B in a certain scheme with a gradual increase for 1 month;
- IdeaLabs Vitamin E - 1 month;
- NOW Rhadiola - from time to time if required;
- NOW DOPA Mucuna - every other day;
- NOW Betaine HCl - each heavy meal;
- Manganese Chelate - for 1 month;
- Wobenzym PS or another system enzymes - for 1 month;
- NMN - for 1 month;
- NOW Silymarin Milk Thistle - 2 months;
- Quicksilver Scientific Liver Sauce - for 1 month
- Kirkman 5-MTHF ([6S]-5-Methyltetrahydrofolate) 5 mg OR MethylPro B-Complex + 5 mg L-Methylfolate
Supplements we're not sure yet if we should start taking them:
- Solgar L-tyrosine + GABA for one month but not together with NOW DOPA Mucuna;
Detox Plan: Quicksilver IMD or BioRay NDF Plus or QuickSilver Quad.
So, guys, what are you thinking about:
1. Do you think that doses, ingredients, frequency are OK or do you think we should change something?
2. What do you thing about simultaneous intake of these supplements?
3. What do you think about the detox plan and the option to gradually increase the T3 to 6 mcg 4 times a day? And the T4?
P.S. We know that Dr. Peat does not believe that antibodies really exist the way they've been explained by modern medicine.
| Name of the test | Result | Unit | Reference | Method |
| Cholesterol | 5.04 | mmol/l | 0-5.17 | PHOT |
| LDL-cholesterol | 3.92 | mmol/l | 0 - 3.36 | PHOT |
| HDL-cholesterol | 1.43 | mmol/l | > 1.68 | PHOT |
| VLDL-cholesterol | 0.61 | mmol/l | 0-0.65 | PHOT |
| Triglycerides | 1.34 | mmol/l | 0-1.71 | PHOT |
| ASAT(GOT) | 14 | U/l | 4-31 | PHOT |
| ALAT(GPT) | 12 | U/l | 0-33 | PHOT |
| GGT | 15 | U/l | 0-50 | PHOT |
| Potassium | 5.8 | mmol/l | 3.5-5.6 | ISE |
| Sodium | 146 | mmol/l | 131-156 | ISE |
| Calcium | 2.35 | mmol/l | 2.12-2.62 | PHOT |
| Magnesium | 0.91 | mmol/l | 0.7-1.2 | PHOT |
| Iron | 5.21 | umol/l | 5.8-34.5 | PHOT |
| FT3 | 4.53 | pmol/l | 3.1-6.8 | ECLIA |
| FT4 | 16.12 | pmol/l | 12.0-22.0 | ECLIA |
| TSH | 1.46 | uIU/ml | 0.27-4.2 | ECLIA |
| TAT/anti-TG | 278 | IU/ml | 0-115 | ECLIA |
| MAT/anti-TPO | 394 | IU/ml | 0-34 | ECLIA |
| TSH-R-Ab | 0.80 | IU/l | 0-1.58 | ECLIA |
| reverse T3 | 192 | pg/ml | 90-2158 | - |
| Testosteron | 1.13 | nmol/l | 0.29-1.67 | ECLIA |
| SHBG | 102.3 | nmol/l | 26.1-110 | ECLIA |
| Calcitonin | 2.68 | pg/ml | 0-6.4 | ECLIA |
| Thyreoglobulin | 41.06 | ng/mll | 3.5-77 | ECLIA |
| Vitamin B12 | 300.2 | pmol/l | 171 - 920 | ECLIA |
| Folat | 11.2 | nmol/l | 10.4-42.4 | ECLIA |
| Candida albicans IgG (blood) | 33.9 | NTU | 0-30 | ELISA |
| Cadmium-EDTA-blood | 1.8 | NTU | 0-1 | |
| Epinephrine | 56 | ng/l | 0-82 | |
| Serotonin (serum) | 60 | ug/l | 0-292 | |
| 1,25 (OH)2 Vitamin D | 51 | ng/l | 19.9-79.3 | |
| Lead in blood | 8 | ug/l | 0-30 | |
| Mercury (EDTA blood) | 1.5 | ug/l | 0-2 | |
| Zinc (serum) | 13.5 | umol/l | 9-18 | |
| Copper (serum) | 1068 | ug/l | 680-1690 | |
| Selenium | 97 | ug/l | 50-1200 | |
| Norepinephrine (EPL) | 341 | ng/l | 0-499 | |
| Tissue Transglutaminase (Ab IgA) | < 0.1 | U/ml | 0-7 | |
| Iodine (blood) | 75 | ug/l | 40-80 | |
| Iodine (urine) | 388 | ug/l | 100-199 | |
| 1.25 (OH)2 Vitamin D3 | 51 | ng/L | - | |
| Gabapentin | < 0.5 | - | - | |
| Cadmium (urine) | 1.8 | ug/l | 0-1 | |
| AAb tissue transglutaminase IgG | < 0.6 | U/ml | 0-7 | |
| Arsenic in blood | < 1 | ug/l | 0-12 | |
| Dopamine (plasma) | 23 | ng/l | 0-85 | |
| Leptin | 21 | ug/l | 2.43-28 | |
| Adiponectin | 13.54 | - | - | |
| Zonulin (serum) | 31 | ng/ml | 0-48 |
Last edited:
