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Help Fixing My Seemingly Unfixable Problems (Inattentive ADHD, General Fatigue, Minocycline Experience etc.)

ajaxinjection

New Member
Joined
May 8, 2022
Messages
2
Location
United States
To keep things short, I have inattentive ADHD (diagnosed officially). Medication has helped immensely in many sectors, but it has illuminated a whole host of new problems. Some of the main symptoms of inattentive ADHD that I feel most directly are the scarily bad memory, lack of in-the-moment presence, sluggish cognitive tempo, something akin to auditory processing disorder, and trouble starting things. Switching topics a little bit, as a teen I was given minocycline for what was presumed to be dermatitis. For all my life I have been plagued with very dry skin (flaky, not cracking though) and rosacea. The minocycline helped for a while, but the serotonin-increasing effects really started to make themselves apparent. All the markers were there (sensitivity to light/sound, general fatigue, muscle weakness, anhedonia, lack of motivation, insane irritability, a dark blotch of hyperpigmented skin on my foot). I'll never forget the first couple days off of it after about a year of taking it (too long), I literally felt so much better. The acne is now back, as well as the very dry skin, and I don't feel nearly as good as those first few days off of it. Now, I am worried that it might have damaged my gut bacteria because of its potent effects and the duration that I took it. I will simplify this block of text below and add a little more info to this disjointed paragraph.

Apparent Problems:
- inattentive ADHD
- (very bad memory, auditory processing disorder, lack of motivation, tendency to space out, overthinking, mood swings)
- skin problems
-(dry flaky skin, rosacea, redness)
- general fatigue/muscle weakness from doing just about anything
- history of gut issues/diarrhea

Known Medical History:
- Hashimoto's on my mother's side (all the women afflicted, unsure if I have it or not, have not experience weight gain, hair thinning or depression)
- Rosacea on my dad's side (along with other indicators that point mitochondrial dysfunction)
- Tonsils and Adenoids removed, sleep breathing problems as a kid (still existent?)
- ADHD (or at least the symptoms) on both sides
- Inflammation issues on both sides
- Very, very skinny throughout most of my life. Very low body fat (like 7%)

Dietary/Supplementary Intake:
- Fish Oils (Have genuinely been a positive, have gotten rid of the stomach ache but I suspect the absorption issues might still be there)
- Nutridyn Essential Multi-Vitamin
- 500 mg of Vitamin C
- Nutridyn Magnesium Glycinate
- Occasional Nutridyn "Methyl Complete"
- Adderall (for ADHD)
- Mostly carbs and salt in the diet, little to no craving for sugar. Honestly not very good, but my schedule and situation make it so that my choices to eat (if I eat at all) are very limited. Very consistent, though.

Any and all help is appreciated immensely.
 

mostlylurking

Member
Joined
May 13, 2015
Messages
1,397
Location
Texas
To keep things short, I have inattentive ADHD (diagnosed officially). Medication has helped immensely in many sectors, but it has illuminated a whole host of new problems. Some of the main symptoms of inattentive ADHD that I feel most directly are the scarily bad memory, lack of in-the-moment presence, sluggish cognitive tempo, something akin to auditory processing disorder, and trouble starting things. Switching topics a little bit, as a teen I was given minocycline for what was presumed to be dermatitis. For all my life I have been plagued with very dry skin (flaky, not cracking though) and rosacea. The minocycline helped for a while, but the serotonin-increasing effects really started to make themselves apparent. All the markers were there (sensitivity to light/sound, general fatigue, muscle weakness, anhedonia, lack of motivation, insane irritability, a dark blotch of hyperpigmented skin on my foot). I'll never forget the first couple days off of it after about a year of taking it (too long), I literally felt so much better. The acne is now back, as well as the very dry skin, and I don't feel nearly as good as those first few days off of it. Now, I am worried that it might have damaged my gut bacteria because of its potent effects and the duration that I took it. I will simplify this block of text below and add a little more info to this disjointed paragraph.

Apparent Problems:
- inattentive ADHD
- (very bad memory, auditory processing disorder, lack of motivation, tendency to space out, overthinking, mood swings)
- skin problems
-(dry flaky skin, rosacea, redness)
- general fatigue/muscle weakness from doing just about anything
- history of gut issues/diarrhea

Known Medical History:
- Hashimoto's on my mother's side (all the women afflicted, unsure if I have it or not, have not experience weight gain, hair thinning or depression)
- Rosacea on my dad's side (along with other indicators that point mitochondrial dysfunction)
- Tonsils and Adenoids removed, sleep breathing problems as a kid (still existent?)
- ADHD (or at least the symptoms) on both sides
- Inflammation issues on both sides
- Very, very skinny throughout most of my life. Very low body fat (like 7%)

Dietary/Supplementary Intake:
- Fish Oils (Have genuinely been a positive, have gotten rid of the stomach ache but I suspect the absorption issues might still be there)
- Nutridyn Essential Multi-Vitamin
- 500 mg of Vitamin C
- Nutridyn Magnesium Glycinate
- Occasional Nutridyn "Methyl Complete"
- Adderall (for ADHD)
- Mostly carbs and salt in the diet, little to no craving for sugar. Honestly not very good, but my schedule and situation make it so that my choices to eat (if I eat at all) are very limited. Very consistent, though.

Any and all help is appreciated immensely.
Sounds like gut issues with thiamine deficiency. These tend to run together because if you lose your ability to absorb nutrients in your small intestine you won't be able to absorb thiamine (B1). Thiamine + magnesium help heal the gut. I'm very positive about thiamine because I've personally resolved a lot of health problems via high dose thiamine hcl, including some serious gut issues including SIBO and leaky gut, along with multiple digestive tract problems like low stomach acid and lack of peristalsis which caused food to not go down my esophagus, get stuck, and forcing a lot of trips from the table to yak up the food in the bathroom.

Here are some links for your consideration:
Rosacea: Rosacea, inflammation, and aging: The inefficiency of stress
quote: "One nearly ubiquitous source of inappropriate excitation and energy depletion is the endotoxin, bacterial lipopolysaccharides absorbed from the intestine (Wang and White, 1999). That this ubiquitous toxin has a role in rosacea is suggested by the observation that intestinal stimulation, to speed transit through the bowel, immediately relieved symptoms (Kendall, 2002). Increased cortisol (Simon, et al., 1998) and sepsis (Levy, 2007) interfere with mitochondrial energy production."

fish oil: The Great Fish Oil Experiment Fish oil is polyunsaturated fat. Terrible stuff. Here's another: Unsaturated fatty acids: Nutritionally essential, or toxic?

a thiamine overview: The Deficiency that Makes You Tired & Weak

ADHD and thiamine:


 

redsun

Member
Joined
Dec 17, 2018
Messages
2,439
To keep things short, I have inattentive ADHD (diagnosed officially). Medication has helped immensely in many sectors, but it has illuminated a whole host of new problems. Some of the main symptoms of inattentive ADHD that I feel most directly are the scarily bad memory, lack of in-the-moment presence, sluggish cognitive tempo, something akin to auditory processing disorder, and trouble starting things. Switching topics a little bit, as a teen I was given minocycline for what was presumed to be dermatitis. For all my life I have been plagued with very dry skin (flaky, not cracking though) and rosacea. The minocycline helped for a while, but the serotonin-increasing effects really started to make themselves apparent. All the markers were there (sensitivity to light/sound, general fatigue, muscle weakness, anhedonia, lack of motivation, insane irritability, a dark blotch of hyperpigmented skin on my foot). I'll never forget the first couple days off of it after about a year of taking it (too long), I literally felt so much better. The acne is now back, as well as the very dry skin, and I don't feel nearly as good as those first few days off of it. Now, I am worried that it might have damaged my gut bacteria because of its potent effects and the duration that I took it. I will simplify this block of text below and add a little more info to this disjointed paragraph.

Apparent Problems:
- inattentive ADHD
- (very bad memory, auditory processing disorder, lack of motivation, tendency to space out, overthinking, mood swings)
- skin problems
-(dry flaky skin, rosacea, redness)
- general fatigue/muscle weakness from doing just about anything
- history of gut issues/diarrhea

Known Medical History:
- Hashimoto's on my mother's side (all the women afflicted, unsure if I have it or not, have not experience weight gain, hair thinning or depression)
- Rosacea on my dad's side (along with other indicators that point mitochondrial dysfunction)
- Tonsils and Adenoids removed, sleep breathing problems as a kid (still existent?)
- ADHD (or at least the symptoms) on both sides
- Inflammation issues on both sides
- Very, very skinny throughout most of my life. Very low body fat (like 7%)

Dietary/Supplementary Intake:
- Fish Oils (Have genuinely been a positive, have gotten rid of the stomach ache but I suspect the absorption issues might still be there)
- Nutridyn Essential Multi-Vitamin
- 500 mg of Vitamin C
- Nutridyn Magnesium Glycinate
- Occasional Nutridyn "Methyl Complete"
- Adderall (for ADHD)
- Mostly carbs and salt in the diet, little to no craving for sugar. Honestly not very good, but my schedule and situation make it so that my choices to eat (if I eat at all) are very limited. Very consistent, though.

Any and all help is appreciated immensely.
If your diet is mostly "carbs and salt", than its no wonder you have these issues. If you are not eating much animal protein, you have no raw material to make neurotransmitters. Amino acids and choline are necessary to make neurotransmitters to motivate you, promote easier focus and attention, improve and stabilize your mood. Working memory and long term memory will be bad as well. Acetylcholine(Ach) is mainly necessary for long term memory and if you aren't getting plenty of choline Ach activity will be low. Working memory is dependent on glutamate, dopamine, noradrenaline... Again, all of these things come from amino acids from protein.

All these vitamins you take are basically useless. You need protein for aminos otherwise your brain will never work in a million years no matter how much you want it to. The first thing I recommend you do is figure out how much protein and choline you get daily and lets see where your intake is at in terms of these.

The fact that you also have generalized weakness, especially weakness upon exertion, confirms likely acetylcholine synthesis is too low due to low choline intake. Acetylcholine is what tells your muscles to contract. Low ach supply will cause debilitating fatigue that gets worse from any physical activity.
 
Last edited:

ajaxinjection

New Member
Thread starter
Joined
May 8, 2022
Messages
2
Location
United States
If your diet is mostly "carbs and salt", than its no wonder you have these issues. If you are not eating much animal protein, you have no raw material to make neurotransmitters. Amino acids and choline are necessary to make neurotransmitters to motivate you, promote easier focus and attention, improve and stabilize your mood. Working memory and long term memory will be bad as well. Acetylcholine(Ach) is mainly necessary for long term memory and if you aren't getting plenty of choline Ach activity will be low. Working memory is dependent on glutamate, dopamine, noradrenaline... Again, all of these things come from amino acids from protein.

All these vitamins you take are basically useless. You need protein for aminos otherwise your brain will never work in a million years no matter how much you want it to. The first thing I recommend you do is figure out how much protein and choline you get daily and lets see where your intake is at in terms of these.

The fact that you also have generalized weakness, especially weakness upon exertion, confirms likely acetylcholine synthesis is too low due to low choline intake. Acetylcholine is what tells your muscles to contract. Low ach supply will cause debilitating fatigue that gets worse from any physical activity.
Sounds like gut issues with thiamine deficiency. These tend to run together because if you lose your ability to absorb nutrients in your small intestine you won't be able to absorb thiamine (B1). Thiamine + magnesium help heal the gut. I'm very positive about thiamine because I've personally resolved a lot of health problems via high dose thiamine hcl, including some serious gut issues including SIBO and leaky gut, along with multiple digestive tract problems like low stomach acid and lack of peristalsis which caused food to not go down my esophagus, get stuck, and forcing a lot of trips from the table to yak up the food in the bathroom.

Here are some links for your consideration:
Rosacea: Rosacea, inflammation, and aging: The inefficiency of stress
quote: "One nearly ubiquitous source of inappropriate excitation and energy depletion is the endotoxin, bacterial lipopolysaccharides absorbed from the intestine (Wang and White, 1999). That this ubiquitous toxin has a role in rosacea is suggested by the observation that intestinal stimulation, to speed transit through the bowel, immediately relieved symptoms (Kendall, 2002). Increased cortisol (Simon, et al., 1998) and sepsis (Levy, 2007) interfere with mitochondrial energy production."

fish oil: The Great Fish Oil Experiment Fish oil is polyunsaturated fat. Terrible stuff. Here's another: Unsaturated fatty acids: Nutritionally essential, or toxic?

a thiamine overview: The Deficiency that Makes You Tired & Weak

ADHD and thiamine:


I genuinely appreciate both responses. I will see what I can do.
 

mostlylurking

Member
Joined
May 13, 2015
Messages
1,397
Location
Texas
I genuinely appreciate both responses. I will see what I can do.
There's a connection between low acetylcholine and thiamine deficiency.

@redsun is right about the diet and the importance of protein. Ray Peat recommends at least 80 grams of high quality protein/day, 100 grams/day is even better. He prefers other animal protein sources instead of muscle meat, like dairy and eggs. An egg has 6 grams of protein; milk has 1 gram of protein per ounce of milk.
 

Phosphor

Member
Joined
Jan 30, 2021
Messages
127
Rather than suggesting you take MORE stuff, I'm going to suggest you find out what you're ingesting that could be causal, at least for some things.
There is a blood test that checks for which foods/supps/chemicals are inflammatory for you in particular; it's called the MRT, is not cheap, and can make a tremendous difference by only ingesting those things which *your* body doesn't have an inflammatory reaction to. This is NOT an "allergy" test.
here is one online source; so far it's the least expensive and has the least "controlling input from the provider."


I would also seriously consider whether you have histamine reactions to things you ingest. Histamine is associated with some pretty awful mental symptoms and the person suffering it has no idea. Best site I've found for that is mastcell360.com

Best of luck. Don't chase symptoms; chase causes.
 

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