Has Anyone Ever Taken 5g+ Niacinamide In One Sitting?

[youngsinatra]

Niacinamide above RDI gets quickly degraded and excreted as methylated niacin metabolites in the urine. High dose niacinamide will probably help people with overmethylation due to methyl pool depletion, but it will not necessarily help because of NAD+ synthesis.

I think glycine is a better endogenous methyl buffer, without the risk of undermethylating. Methylation is critical for liver health as well.

 

[Dr. B]

Niacinamide above RDI gets quickly degraded and excreted as methylated niacin metabolites in the urine. High dose niacinamide will probably help people with overmethylation due to methyl pool depletion, but it will not necessarily help because of NAD+ synthesis.

I think glycine is a better endogenous methyl buffer, without the risk of undermethylating. Methylation is critical for liver health as well.

niacinamide can cause undermethylation for susceptible people or maybe if used long term without supplementing methyl stuff