"Happy Hypoxia" Noted In COVID-19 Patients

ALS

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A strange phenomenon dubbed “happy hypoxia” has baffled doctors treating coronavirus patients who describe themselves as comfortable despite dangerously low oxygen levels that would typically leave them unconscious, or even dead, according to reports.

The mysterious condition that appears to defy basic biology is raising questions about how COVID-19 attacks the lungs, the Guardian reported.

While a healthy person’s blood-oxygen saturation is at least 95 percent, doctors have reported some coronavirus-stricken patients with levels in the 80s or 70s — with some extreme cases below 50 percent, according to the outlet.

And yet these so-called “happy hypoxics” have been observed scrolling on their phones, chatting with their health care providers and describing themselves as generally comfortable, Science Magazine reported.
 

burtlancast

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Maybe it just unveils an unsuspected defect in the way oxygen is conventionally measured in the blood ?
 

Perry Staltic

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Doctors have seen happy hypoxemia before, but they've never seen it in the context of thinking it's caused by a deadly virus. Therefore, in their clinical pathways mindset they didn't pay that much attention to it. Now they assume it's caused by, and unique to, a virus because that's the way they're programmed to think. But there's a very large and real possibility that many presentations of it are due to serotonin poisoning.

How many people have shown up at hospitals with serotonin toxicity due to interactions of their serotonergic polypharmacy (eg, SSRI, SNRI, tricyclics, analgesics, proton pump inhibitors, ACE inhibitors, etc) with other serotonergic agents (cough syrup, supplements, food, recreational drugs, etc), been diagnosed with covid and given more serotonergic drugs as treatment that increase serotonin poisoning (eg, sedatives, antiemetics, antianxiolytics, antivirals, etc.), and then be put on a ventilator that induces platelets to release more serotonin via endothelial damage caused by lung barotrauma, and given serotonergic drugs to comatize intubated patients (eg, fentanyl)? It's mind boggling.

Serotonin syndrome DOES cause “silent hypoxemia” ... I’m looking at it. No - patient doesn’t have COVID19. Yes - eventually required intubation due to agitation and delirium after a few days but persistently hypoxic. Normal chest X-ray. Normal VQ scan. Normal CT chest. No DVT. Labs eerily similar to COVID19. SUSTAINED PLASMA SEROTONIN ELEVATION WILL CAUSE A SYNDROME INDISTINGUISHABLE FROM COVID19 IN HUMANS ...

 
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Perry Staltic

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Do you think the waxy looking film is caused by the ventilator or is it just happening prior to going in to the hospital?

I think "film" is referring to the ground glass opacities they frequently see in chest xrays. SSRIs/SNRIs used long term can cause interstitial lung fibrosis.

 

Elast1c

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I think "film" is referring to the ground glass opacities they frequently see in chest xrays. SSRIs/SNRIs used long term can cause interstitial lung fibrosis.

What a clutch answer lol tyvm
 

Perry Staltic

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To better answer your question, it's definitely caused by ventilators, but also probably by other things before that point.

Here's an example that shows how ventilators can damage lungs. Not actually ventilators themselves, but the settings used (pressures, volumes, timing, etc). On the left is a chest x-ray of an intubated patient on conventional ventilator settings that shows a lot of opacity caused by inflammation or edema. Caused by a disease or the ventilator?

On the right is a chest x-ray of the same patient taken 3 hours after the doctor changed the ventilator setting to APRV which allows a patient to breathe spontaneously and doesn't injure the lungs with PEEP (high pressure at end of breath used to keep collapsed alveoli open) used in conventional settings. Great reduction in lung opacities after only 3 hours. The medical establishment doesn't use APRV with covid; individual doctors like this maverick might.

 
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Elast1c

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Here's an example that shows how ventilators can damage lungs. Not actually ventilators themselves, but the settings used (pressures, volumes, timing, etc). On the left is a chest x-ray of an intubated patient that shows a lot of opacity caused by inflammation or edema. Caused by a disease or the ventilator?

On the right is a chest x-ray of the same patient taken 3 hours after the doctor changed the ventilator setting to APRV which allows a patient to breathe spontaneously and doesn't injure the lungs with PEEP (high pressure at end of breath used to keep collapsed alveoli open) used in conventional settings. Great reduction in lung opacities after only 3 hours. The medical establishment doesn't use APRV with covid; individual doctors like this maverick might.


It's crazy that it's only now getting play time
 

Perry Staltic

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It's crazy that it's only now getting play time

This MD sums it up nicely. What doctors are seeing now existed before as outliers that were diagnosed as ARDS, which resulted in sub-optimal treatments for patients. Now many patients with covid are diagnosed with ARDS resulting in sub-optimal treatment because ARDS is the wrong diagnosis; it's a clinical pathways approach to medicine (protocolized care) rather than a physiological approach. Dr Jalali mentioned above is using a physiological approach (what is actually happening physiologically rather than matching symptoms to a check-off list).

COVID is simply one of the many outlier acute pulm conditions for which an ARDS designation may trigger suboptimal protocolized care Suddenly the ICU is filled with the outliers which were always there in low numbers COVID, because of its numbers has simply exposed the truth

 
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vetiver

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Doctors have seen happy hypoxemia before, but they've never seen it in the context of thinking it's caused by a deadly virus. Therefore, in their clinical pathways mindset they didn't pay that much attention to it. Now they assume it's caused by, and unique to, a virus because that's the way they're programmed to think. But there's a very large and real possibility that many presentations of it are due to serotonin poisoning.

How many people have shown up at hospitals with serotonin toxicity due to interactions of their serotonergic polypharmacy (eg, SSRI, SNRI, tricyclics, analgesics, proton pump inhibitors, ACE inhibitors, etc) with other serotonergic agents (cough syrup, supplements, food, recreational drugs, etc), been diagnosed with covid and given more serotonergic drugs as treatment that increase serotonin poisoning (eg, sedatives, antiemetics, antianxiolytics, antivirals, etc.), and then be put on a ventilator that induces platelets to release more serotonin via endothelial damage caused by lung barotrauma, and given serotonergic drugs to comatize intubated patients (eg, fentanyl)? It's mind boggling.




Yes and high serotonin makes you emotionally/spatially/somatically numb. People have forgotten what it its like to feel good.
 
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