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Grapefruit - Yes/No

Discussion in 'Fruits' started by jaywills, Jul 26, 2015.

  1. jaywills

    jaywills Member

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    What is the general consensus on Grapefruit?

    Other than a line stating it is Estrogenic, I cannot find any mention of this fruit throughout Ray Peats articles/ this forum.

    However, Functional Alps seem to favor its ability to aid the liver:

    http://www.functionalps.com/blog/2011/1 ... -estrogen/
     
  2. Zachs

    Zachs Member

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    Seems like oranges and lemons would be a better combo for sugar, minerals and liver function.
     
  3. DaveFoster

    DaveFoster Member

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    If consumption of grapefruit inhibits the P-450 IIIA4 enzyme, and this enzyme catalyzes estrogen hydroxylation in the liver, then it follows that there would be a net decrease in estrogen deactivation in the liver. Thus, the liver undergoes fewer metabolic processes in this context, so of course the impact on the liver will be less.

    I may be missing a major piece here, but why would you want to increase the amount of estradiol in your system by inhibiting your liver's ability to hydroxylate?
     
  4. Westside PUFAs

    Westside PUFAs Member

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    No that is not what his post implies. The goal is to reduce estrogen and support the liver, not the opposite.
     
  5. Peatit

    Peatit Member

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    I don't understand why other citrus fruits (so oranges, lemons or orange juice) would have a different (activating or at least non inhibiting) mechanism of action on cytochrome P-450 IIIA4 insofar in the studies mentioned, the compounds involved are present in all citrus fruits (naringenin, quercetin and kaempherol) :?:
     
  6. mt_dreams

    mt_dreams Member

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    Grapefruit have roughly 10-15x the amount of naringenin than lemons & oranges. Oranges having roughly 7% compared to grapefruit, while lemons are probably closer to 10% range of grapfruit. Re grapefruit, the white ones have roughly double of this compound compared to the pink variety.
     
  7. Peatit

    Peatit Member

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    Thank you for the explanation. What about mandarin oranges?
     
  8. Parsifal

    Parsifal Member

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    I'm a bit lost, I thought that naringenin was good and anti-oestrogenic but it seems higher in grapefruit that is highly oestrogenic.
     
  9. ecstatichamster

    ecstatichamster Member

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    it's a mixed bag with naringenin, it seems to be a phytoestrogen that in some cases can lower estrogen levels. I don't think huge amounts are healthy. It is like quercetin to me, has benefits but also definitely has an estrogenic effect on me (quercetin does). So I am not big on grapefruits these days.
     
  10. beachbum

    beachbum Member

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    I know this is an old thread, but confused on the answer here. how does grapefruit estrogen an liver.

    EDIT: NEVERMIND I FOUND MY ANSWER
     
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