1. **NEW** BL11 - Orange, Red & Infrared Therapy Body Light
    CLICK HERE!
    Dismiss Notice
  2. PL1 - Orange & Red Light Therapy Pod Light
    CLICK HERE!
    Dismiss Notice

Gonadin - Steroid Optimizer For R&D

Discussion in 'IdeaLabs' started by haidut, Feb 17, 2017.

  1. Joeyd

    Joeyd Member

    Joined:
    Jul 13, 2014
    Messages:
    931
    That just means high adrenaline no? Did you have enough food with it?
     
  2. Joeyd

    Joeyd Member

    Joined:
    Jul 13, 2014
    Messages:
    931
    Same with me. Would be good to know what's going on there.
     
  3. Black Ops

    Black Ops Member

    Joined:
    Feb 14, 2017
    Messages:
    53
    Gender:
    Male
    Most likely the increase in progesterone caused this. I doubt the estrogen is at fault due to phytol being a potent aromatase inhibitor.
     
  4. managing

    managing Member

    Joined:
    Jun 19, 2014
    Messages:
    754
    I don't recall precisely anymore. But very low. 2.5mg subling dhea I believe and one or two drops pansterone.
     
  5. Joeyd

    Joeyd Member

    Joined:
    Jul 13, 2014
    Messages:
    931
    @haidut I've had what I thought as a Cortisol belly for years. You know the type, skinny legs but big baloon of a belly. Seems to run in the family as my brother and dad have it too.

    4 drops of gonadin and I'm flat! Amazing.

    So is it actually estrogen that causes the bloated belly rather than cortisol?
     
  6. Joeyd

    Joeyd Member

    Joined:
    Jul 13, 2014
    Messages:
    931
    do you think its more cortisol or estrogen lowering?
     
  7. DCLOSE

    DCLOSE Member

    Joined:
    Jan 7, 2017
    Messages:
    58
    I believe cortisol due to not having much estrogen symptoms.
     
  8. Joeyd

    Joeyd Member

    Joined:
    Jul 13, 2014
    Messages:
    931
    Ahhh so by reducing cortisol it automatically reduces estrogen also?
     
  9. Joeyd

    Joeyd Member

    Joined:
    Jul 13, 2014
    Messages:
    931
    Just to follow up on this. I've been experimenting a lot more with gonadin and really like it. The first time I took it I got the penis shrinking thing but it seems to be only the first time. After that it didn't happen again.

    I feel stronger in my muscles and I think I have more endurance, would that be from testosterone increase?

    Only thing is I can't take it too close to bedtime as it seems to keep me awake with all the energy
     
  10. mr.mag

    mr.mag Member

    Joined:
    Nov 24, 2016
    Messages:
    21
    Gender:
    Male
    what is the interaction between k and e?
     
  11. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    11,727
    Gender:
    Male
    Location:
    USA / Europe
    Search Google for this "site:raypeatforum.com vitamin E and K interaction" without the quotes.
     
  12. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    11,727
    Gender:
    Male
    Location:
    USA / Europe
    Both are involved. Estrogen is also known as "adipin" so it stimulates the accumulation of fat. Cortisol does the same and it also increases synthesis of estrogen, which then increases release of cortisol. So, it is a vicious circle and usually lowering even one of these hormones tends to interrupt it.
    The phytol in Gonadin also apparently lowers the enzyme fatty acid synthase (FASN), which can help with weight loss.
    Toxic effects of phytol and retinol on human glioblastoma cells are associated with modulation of cholesterol and fatty acid biosynthetic pathways
     
  13. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    11,727
    Gender:
    Male
    Location:
    USA / Europe
    Yes, cortisol stimulates aromatase and then estrogen pushes the adrenals to make even more cortisol.
     
  14. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    11,727
    Gender:
    Male
    Location:
    USA / Europe
    Excellent, thanks for the feedback. Yes, the higher energy and better muscle tone could be from higher T.
     
  15. LeeLemonoil

    LeeLemonoil Member

    Joined:
    Sep 24, 2016
    Messages:
    242
    Gender:
    Male
    Brandnew publication on the Test and Progesterone enhancing effects of Gernylgeraniol (mentionend in the first post)
    A novel function of geranylgeraniol in regulating testosterone production. - PubMed - NCBI

    A novel function of geranylgeraniol in regulating testosterone production.
    Ho HJ, et al. Biosci Biotechnol Biochem. 2018.


    Abstract
    Isoprenoids play widely differing roles in various physiological processes in animals and plants. Geranylgeraniol (GGOH) is an isoprenoid found in plants, and is an important metabolic derivative in the isoprenoid/cholesterol synthesis pathway. Earlier studies focused on GGOH's ability to improve the side effects of bisphosphonate therapy by regulating the mevalonate pathway. More recently, the mevalonate pathway-independent effects of GGOH have been described, including anti-inflammatory, anti-tumorigenic, and neuroprotective activities. It is noteworthy that GGOH regulates the steroidogenesis pathway in testis-derived I-10 tumor cells. Testosterone is a hormone produced via steroidogenesis in testicles and plays a role in fetal development and the male reproductive system. GGOH enhanced testosterone and progesterone (its precursor) levels in I-10 cells by activating adenylate cyclase via cAMP/PKA signaling, without altering phosphodiesterase activity. These findings highlight the potential benefits of GGOH as a therapeutic agent for low testosterone levels, such as late-onset hypogonadism in men.
     
  16. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    11,727
    Gender:
    Male
    Location:
    USA / Europe
    Thanks, this is actually from the same authors who did the in vitro studies I posted in the original Gonadi thread. They also mention phytol as having the same effects as GGOH.
    "...Testosterone and progesterone levels in I-10 cell culture mediums markedly increased in the presence of phytol and GGPP, but not in the presence of GOH. Meanwhile, FOH enhanced progesterone, but not testosterone levels. These results indicated that phytol and GGOH have similar effects on testosterone and progesterone production although, unexpectedly, GOH did not affect steroid production in I-10 cells. Recent researches have revealed the biological activity of compounds derived from the isoprenoid/cholesterol synthesis pathway. These isoprenoids, including FOH, GOH, and phytol, regulate various biological processes [47–49]. The results indicated that not only GGOH, but other isoprenoid derivatives, can enhance testosterone and progesterone levels, although the mechanisms by which they exert these effects are yet to be clarified."

    But most importantly (so thank you again for sending this!) in the current study they also did in vivo study with GGOH and found that it again raises T levels. Since the in vitro tests in the previous studies used the same concentration of phytol and GGOH (100 uM/L), we can use this experiment to estimate the needed in vivo dose for phytol. The current study used 48.3 mg/kg of diet in rats, which is 4.83 mg/kg of bodyweight, which is an HED of 0.8 mg/kg. Since phytol has slightly higher molar mass than GGOH the HED for phytol would be 0.816 mg/kg and thus the 100mg a dose of Gonadin provides should be more than enough to replicate this study. As you can see from the attached image, T levels doubled and did so in just 10 days supplementing with GGOH.
    "...We also found that dietary supplementation of MK-4 enhanced plasma testosterone levels in rats, without any alternation of plasma LH levels [45]. Based on the results of our cell-based experiments [32], we conducted further experiments on the effects of GGOH on testosterone production in animals. Eight-week-old Wistar male rats were purchased from SLC Japan (Shizuoka, Japan) and fed either GGOH supplemented (48.3 mg/kg of diet) or control diet for 10 days. Growth performance did not differ between both diets, but plasma testosterone levels in GGOH supplemented group were found to be elevated compared to that of control group, indicating that dietary supplementation of GGOH significantly elevates plasma testosterone levels (unpublished data, Figure 4). These findings provide novel mechanistic insights into the process of testosterone production and may be useful for the development of therapeutic strategies to counter age-associated declines in testosterone levels in men. In summary, the novel role of GGOH in steroidogenesis may bring new possibilities and could be useful in the development of therapeutics for the treatment of men with LOH."
     

    Attached Files:

  17. brentipold

    brentipold Member

    Joined:
    Mar 5, 2015
    Messages:
    23
    I had positive improvements w/ hair on this product, but like most supplements, the results always fade for me.
     
  18. Sonybaloney

    Sonybaloney Member

    Joined:
    Dec 13, 2017
    Messages:
    19
    Gender:
    Female
    Location:
    Utah
    Have there been any positive effects on female rats? What would a female expect from gonadin? I have that cortisol belly, too. Worse in the evening. Any recommendations?
     
Loading...