Glycolysis Vs Glucose Oxidation – Peat Articles

[darbole]

When Peat uses the term glycolysis what does he mean?

My very limited understanding is that glycolysis is the first step of three in glucose oxidation:

Glycolysis => Krebs => Electron Chain

The result of this being the efficient production of energy and co2 – which is optimal.

In his articles, the term glycolysis often seems not to refer to this first step but to something else. Is he referring to something else and if so, what is it?

It seems like the term glycolysis is often used to refer to certain processes that do not end with the production of co2.

 

[Hans]

I think most of the time he refers to anaerobic glycolysis that produces lactate instead of CO2.

 

[ilikecats]

[When you say several effects of CO2 shuts off glycolysis, do you mean anaerobic glycolysis or all glycolysis, if all glycolysis how does glucose enter mitochondria without breaking down to pyruvate?] Meaning the entry of lactate into the blood stream inappropriately, which would usually be called aerobic glycolysis, though you can't be sure how much oxygen is getting to the cells when CO2 is deficient, since its absence causes many problems in oxygen delivery and use. [So when CO2 isn't deficient glycolysis, meaning glucose to pyruvate, is fine?] Yes, as part of oxidative metabolism, it's better than burning too much fat.

 

[RealNeat]

Where do we think this excerpt fits in?

"Interestingly, the rate of lactate clearance from the extracellular space was markedly slowed in the presence of tetrodotoxin, a specific blocker of the neuronal voltage-sensitive sodium channels responsible for the generation of action potentials (11). This latter observation implies that during activation, lactate may normally be taken up by neurons as an energy fuel. It should be remembered that, after conversion to pyruvate, lactate can enter the TCA cycle with the potential to generate a total of 36 mol of ATP/mol of glucose (Fig. 2 ). "

From this link --->
Brain Energy Metabolism

 

[Hans]

Where do we think this excerpt fits in?

"Interestingly, the rate of lactate clearance from the extracellular space was markedly slowed in the presence of tetrodotoxin, a specific blocker of the neuronal voltage-sensitive sodium channels responsible for the generation of action potentials (11). This latter observation implies that during activation, lactate may normally be taken up by neurons as an energy fuel. It should be remembered that, after conversion to pyruvate, lactate can enter the TCA cycle with the potential to generate a total of 36 mol of ATP/mol of glucose (Fig. 2 ). "

From this link --->
Brain Energy Metabolism

I read a study a while back showing that neurons switch their preference from glucose to lactate when its been repeatedly deprived of glucose. So its number one preferred fuel should be glucose still.