Glycine Protects Liver Cells From Mercury Toxicity


May 12, 2015
San Diego, CA
Modulation of mercury-induced mitochondria-dependent apoptosis by glycine in hepatocytes.

Mercury (Hg) is one of the universal environmental pollutants and is responsible for various organ pathophysiology including oxidative stress-induced hepatic disorders. In the present study, we aimed to explore the protective role of glycine in Hg-induced cytotoxicity and cell death in murine hepatocytes. Exposure of mercury (20 μM), in the form HgCl2 for 1 h, significantly enhanced the ALT and ALP leakage, increased reactive oxygen species production, reduced cell viability and distorted the antioxidant status of hepatocytes. Flow cytometric analyses shows that Hg-induced apoptotic death in hepatocytes. Mechanism of this pathophysiology involves reduced mitochondrial membrane potential, variations in Bcl-2/Bad proteins, activation of caspases and cleavage of PARP protein. In addition, Hg distinctly increased NF-κB phosphorylation in association with IKKα phosphorylation and IκBα degradation. Concurrent treatment with glycine (45 mM), however, reduced Hg-induced oxidative stress, attenuated the changes in NF-κB phosphorylation and protects hepatocytes from Hg-induced apoptotic death. Hg also distinctly increased the phosphorylation of p38, JNK and ERK mitogen-activated protein kinase (MAPKs). Glycine treatment suppressed these apoptotic events, signifying its protective role in Hg-induced hepatocyte apoptosis as referred by reduction of p38, JNK and ERK MAPK signaling pathways. Results suggest that glycine can modulate Hg-induced oxidative stress and apoptosis in hepatocytes probably because of its antioxidant activity and functioning via mitochondria-dependent pathways and could be a beneficial agent in oxidative stress-mediated liver diseases.



Jul 17, 2018
Thats great. Unfortunatly i dont tolerate much glycine and sometimes it make me feel pretty off. I struggle primarily with mold toxicity and ive found it disrupt the metabolism of many nutrients, including glycine to some degree.
Similar threads
Thread starter Title Forum Replies Date
zarrin77 Glycine Completely Protects Liver Cells From Apoptosis Due To Iron Scientific Studies 1
haidut Glycine Protects From Iron Toxicity In The Liver Scientific Studies 6
haidut Glycine (and leucine) can treat fatty liver (NAFLD and NASH) Scientific Studies 3
haidut Glycine has a universal anti-viral effect Scientific Studies 38
Lokzo Glycine Reduces NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome - 2020 Supplements, Pharmaceutical Drugs 20
Ras Glycine Ameliorates NAFLD By Modulating FAO, Glutathione Synthesis, And The Gut Microbiome Amino Acids 0
johnwester130 Lamb Lungs Surprisingly High In Glycine Meat, Organ Meat, Gelatin, Seafood 5
johnwester130 The Ultiamte Simple Mouthwash With Glycine Powder Oral Health 37
Amazigh Astronomers Report They’ve Detected The Amino Acid Glycine In The Atmosphere Of Venus Miscellaneous Health Discussions 12
M Percentage Of Glycine In Chelated Calcium Ask For Help or Advice 1
M A Choline-rich Diet (and Glycine) Improves Survival In A Rat Model Of Endotoxin Shock Scientific Studies 0
M Bad Experience With Glycine Ask For Help or Advice 19
Velve921 What Does Everyone Thing Of Sooma For Sleep? It Has Glycine Ask For Help or Advice 0
explosionlord Aspirin + K2 + Glycine Poor Reaction; Anybody Else? Supplements 8
A Gelatin/Glycine In Ground Beef Meat, Organ Meat, Gelatin, Seafood 7
V Foods With A Good Glycine / Methionine Ratio Diet 1
M Your Glycine Experiences? Ask For Help or Advice 35
Hans The Peat Ratio Of Foods (Glycine Vs Methionine, Cysteine And Tryptophan) Discussing Dietary Models 29
M Do You Feel A Difference From Taking Glycine Or Gelatin Or Aspirin? Ask For Help or Advice 5
Hgreen56 Why Are Gelatin And Glycine Recommended If Glycine Increases Serotonin Levels? Supplements, Pharmaceutical Drugs 10
zarrin77 Glycine (and Serine) Have Potent “anti-depressive” Effects In Rodent Endotoxin Model Scientific Studies 0
H Coffee Without Glycine Allergy Diet 2
Ravenslore Why Does My Hair Fall Out If I Don't Take Glycine Daily? Ask For Help or Advice 24
berk Someone Experienced Energy From Glycine? Metabolism 8
michael94 Brain Glycine Levels Not Always Limited To Glycine Intake Meat, Organ Meat, Gelatin, Seafood 2
Jib High-Dose Glycine For OCD And BDD Scientific Studies 4
JoshuaD Glycine And Stress Cortisol, Serotonin, Histamine 44
S Mineral Glycine Chelates Taken In The Morning? Supplements 0
L How To Increase Endogenous Glycine Synthesis? Metabolism 8
GorillaHead Once Again Mitochondrial Dysfunction At The Center Of AGING. Glycine Supplementation Huge Scientific Studies 5
I Glycine Digestion 13
_lppaiva Glycine As A Temporary Alternative To Gelatin, Since No Good Brands Are Available? Supplements, Pharmaceutical Drugs 29
M Taurine Vs. Glycine Regarding Gallstones? Supplements 6
olive Gelatin Enhances Non-gene Iron Uptake, Glycine Does Not Scientific Studies 3
C Pregnenolone + Taurine + Glycine Pregnenolone 4
Gadsie Glycine Inhibits Formation Of Blood Vessels In (colon) Tumors Scientific Studies 1
L Oral Exposure To The Free Amino Acid Glycine Inhibits The Acute Allergic Response In A Model Of Cow' Scientific Studies 13
magnesiumania Glycine, Brands, Dosage Amino Acids 25
R What Am I Making (magnesium, Glycine) Supplements, Pharmaceutical Drugs 2
S Getting Up In The Morning And Glycine Insomnia, Sleep Issues 8
J Glycine And Libido Male Issues 17
cyclops Glycine Vs Powdered Gelatin Diet 45
Lokzo Glyphosate Pretending To Be Glycine: Devastating Consequences Articles & Scientific Studies 46
N During A Fast, Glycine/Niacinamide/Asprin Post Workout? Health 22
RayPeatFan777 Simply Eating Oxtails - Enough Glycine? Meat, Organ Meat, Gelatin, Seafood 27
L Glycine Wake-up After 4 Hours Amino Acids 6
Mito Balancing Methionine And Glycine Amino Acids 6
Captain_Coconut Chamomile Boosts Biosynthesis Of Glycine Amino Acids 12
Captain_Coconut Transdermal Glycine Ask For Help or Advice 5
johnwester130 Milk Is Low In Tryptophan. Actually It Has An Equal Amount To Glycine Diet, Recipes 4

Similar threads