Glycine May Treat Schizophrenia

haidut

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Russian medicine considers glycine a brain drug and it is available by prescription there since the 1950s AFAIK. There has been considerable interest in the Western world lately about so-called glycine agonists for treatment of many psychiatric conditions including bipolar depression, dementia, PTSD, etc. Below are some studies related to glycine research for schizophrenia, and they point to other studies on glycine for many brain conditions. The human dosage used was high - 60g-80g, but it is achievable by supplementation with gelatin or powdered glycine.

http://www.ncbi.nlm.nih.gov/pubmed/9892253
http://www.ncbi.nlm.nih.gov/pubmed/9892251
http://link.springer.com/chapter/10.100 ... _11#page-1
http://www.ncbi.nlm.nih.gov/pubmed/24024940
http://www.ncbi.nlm.nih.gov/pubmed/23194655
http://www.ncbi.nlm.nih.gov/pubmed/23089076
http://en.wikipedia.org/wiki/Sarcosine
 

haidut

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An actual patented drug based on glycine, for treatment of many psychiatric diseases. In Russia it is considered a drug and requires prescription but in US it is available over the counter.

http://en.wikipedia.org/wiki/Noopept
 

haidut

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ttramone said:
Has anyone used Noopept? I was thinking of trying it. It's very cheap.


I have. It gives me a very similar feeling to a large dose (20g) of glycine. Btw, since glycine is very sweet in taste if you find it in powder you can use it as an additional sweetener. Not sure what would be cheaper though - big supply of glycine that will give you 20g+ per day or several boxes of Noopept.
Anyways, for those interested Noopept does seem to give me a brain boost. Especially after taking at night, in the morning I feel ready to learn a new language:):
 

juanitacarlos

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Thanks Haidut. I'm going give Noopept a try - it's cheap enough to experiment with.

After googling, it seems a lot of people say to supp with choline if you try it. All the choline sources I looked at seemed to come from soy. I'd rather avoid it. Did you find a need to supp with choline?
 

haidut

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ttramone said:
Thanks Haidut. I'm going give Noopept a try - it's cheap enough to experiment with.

After googling, it seems a lot of people say to supp with choline if you try it. All the choline sources I looked at seemed to come from soy. I'd rather avoid it. Did you find a need to supp with choline?

Nope, I did not feel the need to supp with choline and would strongly advise against it. As you probably know Peat thinks choline is excitotoxic, which sort of explains why all the cholinergic drugs for Alzheimers have been such a miserable failure, while anticholinergic ones like cyproheptadine are very helpful.
 

Frankdee20

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How does one ensure Glycine will act as an inhibitory transmitter rather than exciting NMDA ?
 

jamies33

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Can anyone describe the difference in feeling from taking glycine and noopept?
 
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