Glycine (and Serine) Have Potent “anti-depressive” Effects In Rodent Endotoxin Model

Discussion in 'Scientific Studies' started by zarrin77, Apr 17, 2020.

  1. zarrin77

    zarrin77 Member

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    Contribution of skeletal muscular glycine to rapid antidepressant effects of ketamine in an inflammation-induced mouse model of depression

    In trying to figure out how ketamine works for depression, the researchers notices that glycine receptors and glycine from skeletal muscle were altered.

    So they then tried to see if glycine and serine decreased the “immobility time” (increased the length of time the rats spent struggling rather than giving up). They worked! And very well.

    The dose used was HED of under 2g i.p. for a large 90kg person. Orally, likely 3-8g (depending on bioavilability) would be effective in humans.

    Edit: and the swim test was performed about 24 hours after the dose!

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