GLA & Loss of delta-6-desaturase activity as a key factor in aging

PUFAisDaProb

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Loss of delta-6-desaturase activity as a key factor in aging.
Horrobin DF.
Abstract

Aging is characterized by a wide variety of defects, particularly in the cardiovascular and immune systems. Cyclic AMP levels fall, especially in lymphocytes. Delta-6-desaturase (D6D) levels have been found to fall rapidly in the testes and more slowly in the liver in aging rats. D6D is an enzyme which converts cis-linoleic acid to gamma-linolenic acid (GLA). Other factors which inhibit D6D activity are diabetes, alcohol and radiation, all of which may be associated with accelerated aging. In meat eaters or omnivores which can acquire arachidonic acid from food, the main consequences of D6D loss will be deficiencies of GLA, dihomogamma-linolenic acid (DGLA) and prostaglandin (PG) E1. PGE1 activates T lymphocytes, inhibits smooth muscle proliferation and thrombosis, is important in gonadal function and raises cyclic AMP levels in many tissues. It is a good candidate for a key factor lost in aging. Moderate food restriction, the only manoeuvre which consistently slows aging in homoiotherms, raises D6D activity by 300%. Other factors important in regulating D6D and the conversion of GLA to PGE1 are zinc, pyridoxine, ascorbic acid, the pineal hormone, melatonin, and possibly vitamin B3. GLA administration to humans has been found to lower blood pressure and cholesterol, and to cause clinical improvement in patients with Sjogren's syndrome, scleroderma and alcoholism. These diseases are associated with some features of accelerated aging. The proposition that D6D loss is not only a marker of aging but a cause of some of its major manifestations is amenable to experimental test even in humans. The blocked enzyme can be by-passed by giving GLA directly.
 

LucH

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PUFAisDaProb said:
post 104884 The blocked enzyme can be by-passed by giving GLA directly.
Not too much GLA, and you have to limit PUFA linoleic acid (main omega-6) very much because of the conversion pathway into protaglandines.


GLA may give PGE 1 (anti-inflamamtory) or take another way (AA) (aracidonic acid). AA is very inflammatory (PGE 2 pathway).
LucH
:yellohello
 

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Apple

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Not too much GLA, and you have to limit PUFA linoleic acid (main omega-6) very much because of the conversion pathway into protaglandines.


GLA may give PGE 1 (anti-inflamamtory) or take another way (AA) (aracidonic acid). AA is very inflammatory (PGE 2 pathway).
LucH
:yellohello
Bump,
I want to increase D6D


How do you increase delta-6 desaturase?
Adequate levels of magnesium, zinc, vitamin C, and vitamin B6 should be maintained by supplementation if intake of any of these nutrients is insufficient in the diet, to enhance the function of the delta-6 desaturase.


23971548.jpg
 

LucH

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How do you increase delta-6 desaturase?
Adequate levels of magnesium, zinc, vitamin C, and vitamin B6 should be maintained by supplementation if intake of any of these nutrients is insufficient in the diet, to enhance the function of the delta-6 desaturase.
Yes but not always functional, whenever overload or problems ...
Inhibitors of the D-6-D enzyme essential for the formation of D-Gla (and avoid conversion to AA, pro-inflammatory if in excess)
- Age
- Alcohol
- Chemical carcinogen
- Diet rich in cholesterol
- Diet rich in saturated fat
- Diet rich in sugar
- Diabetes
- Low diet in Mg Zn
- Diet poor in B6 and live C
- Radiation
- Trans linoleic acid (omega-6 trans / ALA)
- Viral disease
- Genetic disease
=> Please Mind the eaters of starchy foods in pastries (transfats: We can manage 2 gr a day) and people contaminated by heavy metals. I’d still add the people who abused from oxalates (50 mg per day, tolerance threshold at 200 mg) because impact on the methylation pathway (via the Enzymes dam using sulfur). We are quickly there if you eat dome.
Make a Google search with: « Impact négatif de l’oxalate sur le métabolisme : Chaos biochimique ! » + Chez Mirzoune et Ciboulette
Mind spinach, sweet potato, rhubarb, beet, etc. Need extra Ca citrate to neutralize (lithiase).
 

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