Generative Energy #9: A Bioenergetic View of Weight Loss (with Haidut)
http://raypeat.com/articles/articles/re ... tion.shtml
"...Saturated fats activate the pyruvate dehydrogenase enzyme that is essential for the efficient use of glucose, while PUFA block it. (The MRL mouse strain has a high regenerative ability, associated with a retained tendency to metabolize glucose rather than fatty acids.) The negative energetic effects of PUFA include interfering with thyroid and progesterone. The energy resources are suppressed, at the same time that the inflammatory signals are amplified, and many regulatory pathways (including the replenishment of NAD from tryptophan) are diverted."
http://www.jlr.org/content/44/11/2135.full.pdf
"...It has been shown that dietary PUFA caused a marked inhibitory effect on total and active pyruvate dehydrogenase complex (47). TCC represents a link between carbohydrate catabolism and fatty acid synthesis (48)".
Soy oil increases pyruvate dehydrogenase kinase, which inhibits pyruvate dehydrogenase.
http://journals.plos.org/plosone/articl ... ne.0132672
"...One of these genes, Pdk4, which was upregulated in SO-HFD livers, is known to inhibit the pyruvate dehydrogenase complex that links the TCA cycle with glucose and fatty acid metabolism. Repression of the pyruvate dehydrogenase complex shifts the balance towards gluconeogenesis which could result in hyperglycemia [76]."
deeri681 said:post 110414 Hi Haidut,
Do you have the research articles that sites palmitic acid, Stearic acid, and lauric acid as the saturated fats that do not inhibit pyruvate dehydrogenase?
Thank so much,
Kate
http://raypeat.com/articles/articles/re ... tion.shtml
"...Saturated fats activate the pyruvate dehydrogenase enzyme that is essential for the efficient use of glucose, while PUFA block it. (The MRL mouse strain has a high regenerative ability, associated with a retained tendency to metabolize glucose rather than fatty acids.) The negative energetic effects of PUFA include interfering with thyroid and progesterone. The energy resources are suppressed, at the same time that the inflammatory signals are amplified, and many regulatory pathways (including the replenishment of NAD from tryptophan) are diverted."
http://www.jlr.org/content/44/11/2135.full.pdf
"...It has been shown that dietary PUFA caused a marked inhibitory effect on total and active pyruvate dehydrogenase complex (47). TCC represents a link between carbohydrate catabolism and fatty acid synthesis (48)".
Soy oil increases pyruvate dehydrogenase kinase, which inhibits pyruvate dehydrogenase.
http://journals.plos.org/plosone/articl ... ne.0132672
"...One of these genes, Pdk4, which was upregulated in SO-HFD livers, is known to inhibit the pyruvate dehydrogenase complex that links the TCA cycle with glucose and fatty acid metabolism. Repression of the pyruvate dehydrogenase complex shifts the balance towards gluconeogenesis which could result in hyperglycemia [76]."
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