tyw
Member
Good conversation . The statement (that is roughly paraphrased as) "Cancer cells have excess negative charge on their surface" caught my attention, so I decided to verify it.
And the answer is, "Yes, this is true"
- 'Changes in Electric Properties of Human Breast Cancer Cells', (Dobrzyńska et. al., 2013) -- Changes in Electric Properties of Human Breast Cancer Cells
- 'The Surface Properties of Cancer Cells: A Review', (Abercrombie M and Ambrose EJ, 1962) -- The surface properties of cancer cells: a review. - PubMed - NCBI (full text: http://cancerres.aacrjournals.org/content/22/5_Part_1/525.full.pdf )
NOTE: the authors Barbara Szachowicz-Petelska and Izabela Dobrzyńska often come up in many of such studies:
- Phospholipid Composition and Electric Charge in Healthy and Cancerous Parts of Human Kidneys
- Characterization of Human Bladder Cell Membrane During Cancer Transformation
- Phospholipid Composition and Electric Charge in Healthy and Cancerous Parts of Human Kidneys
Basically, cancerous cells of all forms exhibit excess negative charge potential at low pH, and excess positive charge potential at high pH -- ie: charge dys-regulation. (This is referring to membrane charge potential)
That second paper hints at lack of normal cell behaviour due to continuous repulsion. Normal cells stick together, cancerous cells don't. They explain it in terms of charge repulsion, and I actually think that is plausible.
Note that we have to specifically refer to this phenomena as less charge differential between membrane and cytoplasm. All the studies measured "charge" as "delta potential". Again, we're talking "Dys-regulation", not necessarily Less Absolute Energy in the cell.
If you are a Mae-Wan Ho fan, this would be "Decoherence" -- less ability to transfer charge to where it needs to go; it "spreads out everywhere". Coherence => resonance => common frequencies => channel for charge.
Now the important question "What promotes coherence?". I am biased, I look at Guenter Albrecht-Buehler's work and say that it is good metabolism that allows for coherence -- http://www.basic.northwestern.edu/g-buehler/cellint0.htm
(He basically showed how cells use Red to Infrared light signalling from mitochondria to send signals to each other, and how groups of cells made decisions faster and more accurately than single cells or smaller groups of cells)
....
And the answer is, "Yes, this is true"
- 'Changes in Electric Properties of Human Breast Cancer Cells', (Dobrzyńska et. al., 2013) -- Changes in Electric Properties of Human Breast Cancer Cells
- 'The Surface Properties of Cancer Cells: A Review', (Abercrombie M and Ambrose EJ, 1962) -- The surface properties of cancer cells: a review. - PubMed - NCBI (full text: http://cancerres.aacrjournals.org/content/22/5_Part_1/525.full.pdf )
NOTE: the authors Barbara Szachowicz-Petelska and Izabela Dobrzyńska often come up in many of such studies:
- Phospholipid Composition and Electric Charge in Healthy and Cancerous Parts of Human Kidneys
- Characterization of Human Bladder Cell Membrane During Cancer Transformation
- Phospholipid Composition and Electric Charge in Healthy and Cancerous Parts of Human Kidneys
Basically, cancerous cells of all forms exhibit excess negative charge potential at low pH, and excess positive charge potential at high pH -- ie: charge dys-regulation. (This is referring to membrane charge potential)
That second paper hints at lack of normal cell behaviour due to continuous repulsion. Normal cells stick together, cancerous cells don't. They explain it in terms of charge repulsion, and I actually think that is plausible.
Note that we have to specifically refer to this phenomena as less charge differential between membrane and cytoplasm. All the studies measured "charge" as "delta potential". Again, we're talking "Dys-regulation", not necessarily Less Absolute Energy in the cell.
If you are a Mae-Wan Ho fan, this would be "Decoherence" -- less ability to transfer charge to where it needs to go; it "spreads out everywhere". Coherence => resonance => common frequencies => channel for charge.
Now the important question "What promotes coherence?". I am biased, I look at Guenter Albrecht-Buehler's work and say that it is good metabolism that allows for coherence -- http://www.basic.northwestern.edu/g-buehler/cellint0.htm
(He basically showed how cells use Red to Infrared light signalling from mitochondria to send signals to each other, and how groups of cells made decisions faster and more accurately than single cells or smaller groups of cells)
....