GCN2 Deficiency Protects Against HFD Induced Hepatic Steatosis And Insulin Resistance In Mice

[MrSmart]

Highlights:

• GCN2 is activated in fatty livers and palmitic acid treated HepG2 cells.
• GCN2 deficiency ameliorates high fat diet-induced hepatic steatosis and insulin resistance.
• GCN2 promotes high fat diet-induced lipogenesis and oxidative stress.
• GCN2 regulates PPARγ, FAS and MTs expression via a CHOP dependent manner.

https://doi.org/10.1016/j.bbadis.2018.07.012