_lppaiva
Member
- Joined
- Jul 30, 2019
- Messages
- 116
Dietary fructose exacerbates hepatocellular injury when incorporated into a methionine-choline-deficient diet. - PubMed - NCBI
Being that most here are a fan of longevity, I think the general recommendation is to avoid methionine. I think this study is really important for anyone who relies heavily on fruit and sugar, being most of us here.
I am not sure, however, if "depleation" of methionine by glycine has the same effect. Perhaps a diet "high" (with enough) methionine and an optimal ratio of glycine (and also the other non inflammatory aminoacids) might be the best of both worlds?
"Mice fed MCD formulas developed similar degrees of hepatic steatosis whether they contained glucose or fructose. By contrast, mice fed MCD-fructose developed significantly more hepatocellular injury than mice fed MCD-glucose, judged by histology, apoptosis staining and serum alanine aminotransferase. Liver injury in MCD-fructose mice coincided with an exaggerated rise in the ratio of long-chain saturated to unsaturated fatty acids in the liver. Notably, hepatic inflammation was not enhanced in mice fed MCD-fructose, correlating instead with hepatic lipid peroxidation, which was equivalent in the two MCD groups."
This kinda of bugged me out though:
"The data suggest the enhanced cytotoxicity of fructose in the MCD model is related to its ability to stimulate de novo lipogenesis, which yields harmful long-chain saturated fatty acids."
Wouldn't that be palmitic acid, which haidut has shown is protective?
Being that most here are a fan of longevity, I think the general recommendation is to avoid methionine. I think this study is really important for anyone who relies heavily on fruit and sugar, being most of us here.
I am not sure, however, if "depleation" of methionine by glycine has the same effect. Perhaps a diet "high" (with enough) methionine and an optimal ratio of glycine (and also the other non inflammatory aminoacids) might be the best of both worlds?
"Mice fed MCD formulas developed similar degrees of hepatic steatosis whether they contained glucose or fructose. By contrast, mice fed MCD-fructose developed significantly more hepatocellular injury than mice fed MCD-glucose, judged by histology, apoptosis staining and serum alanine aminotransferase. Liver injury in MCD-fructose mice coincided with an exaggerated rise in the ratio of long-chain saturated to unsaturated fatty acids in the liver. Notably, hepatic inflammation was not enhanced in mice fed MCD-fructose, correlating instead with hepatic lipid peroxidation, which was equivalent in the two MCD groups."
This kinda of bugged me out though:
"The data suggest the enhanced cytotoxicity of fructose in the MCD model is related to its ability to stimulate de novo lipogenesis, which yields harmful long-chain saturated fatty acids."
Wouldn't that be palmitic acid, which haidut has shown is protective?