Found A Gem For Starters - Prevention Of Arachidonic Acid‑induced Liver Injury With Garlic Extracts


New Member
Jan 30, 2020
Hello Guys and gals,

been lurking long enough, trying to learn and apply what i could.
Now starting to contribute my share:

Prevention of arachidonic acid‑induced liver injury by controlling oxidative stress‑mediated transglutaminase activation with garlic extracts

Garlic and its sulfur constituents have numerous biological functions, such as antioxidant, anti‑inflammatory, anti‑microbial, anticancer, antidiabetic and cardioprotective effects. Fatty liver diseases, such as non‑alcoholic steatohepatitis, which is characterized by the accumulation of lipids and oxidative stress in hepatocytes and continual liver damage, has attracted much attention, and it is believed that it will become the leading etiology of liver cancer. We have previously reported that the growth‑suppressive effects of arachidonic acid (AA), an unsaturated fatty acid known to be a pro‑inflammatory precursor, is accompanied by the production of reactive oxygen species followed by the nuclear accumulation and activation of the protein crosslinking enzyme, transglutaminase (TG)2. In this study, we examined the potential role of garlic extracts in preventing the growth‑suppressive effects of AA on human hepatic cells. We also aimed to provide a mechanistic insight regarding the association between the hepatoprotective effects of garlic extract and the inhibition of the TG‑related crosslinking of nuclear proteins, which is not associated with hepatic lipid partitioning mediated by stearoyl‑CoA desaturase‑1. Given the critical roles of unsaturated fatty acids in the regulation of cancer cell stemness and immune surveillance in the context of chronic injury, we propose that garlic extracts may serve as a therapeutic option for the prevention of chronic liver injury and inflammation, as well as for the prevention of the carcinogenesis of fatty livers.



Feb 13, 2016
Very interesting. Thanks for posting.
Similar threads
Thread starter Title Forum Replies Date
Sam321 Silica found in many Whole Foods milk brands Ask For Help or Advice 46
R Had to share pics of these quality eggs I found at a local Chicago supermarket... Dairy, Eggs 11
Hugh Johnson What are these worm-like strands found in masks? Miscellaneous Health Discussions 2
B SARS-CoV-2 found in many countries before the first officially confirmed covid-19 case Viruses, Parasites, Fungus, Vaccines 7
meatbag Venus flytraps found to produce magnetic fields Scientific Studies 0
J I think i've found the best dental filling product Oral Health 22
J Found the best non toxic mattresses in the UK Insomnia, Sleep Issues 1
Hugh Johnson French professor who found links between the Pasteur institute and covid19 forced into a mental asylum. Society 4
H R.I.P ex-Merck rep Brandy Vaughn found dead Viruses, Parasites, Fungus, Vaccines 9
A i've found an online seller of thyroid Synthetic Thyroid 19
joshquintanilla Found A Way To Block ALL Blue Light On IPhone Easily Light 40
S What Have You Found Most Helpful For Your Libido And Sexual Function? Ask For Help or Advice 102
S Found The Safest Soap To Use During Shower Body Care 33
Dino D Covid Cure Found In Bosnien Breaking News 1
mayweatherking Pathologist Found Blood Clots In ‘almost Every Organ’ During Autopsies On COVID-19 Patients Viruses, Parasites, Fungus, Vaccines 46
S Think I've Found The Cause Of My Premature Ejaculation! Male Issues 35
S Think I May Have Found The Cause Of My Erectile Dysfunction/potentially My Premature Ejaculation Male Issues 27
Jake sullivan Iron Bits Found In Refined Sugar? Sugar, Honey 12
jzeno I Finally Found A Food That STRENGTHENS Nails! FRESH PLUM JUICE! Experiments 3
haidut Emulsifiers Found In Most Commercial Foods Cause Brain Tumors, Hemorrhage, And Stroke Scientific Studies 2
B You Have No Idea How Glad I Am To Have Found This Forum K 10
Xisca Oxalate Found In Thyroid In 79% Of Adults Thyroid and Hormones 6
L This Coq10 Supplement I Found In The Mainstream Supermarket Has Coconut Oil In It Supplements, Pharmaceutical Drugs 1
C Has Anyone Found Anything That Regrows Hair? Hair & Nails 21
ScurveDream Is This Mold? Found This Right Above My Bed! Ask For Help or Advice 7
A The Most Androgenic Herbs That I Have Found Supplements, Pharmaceutical Drugs 48
C I Found The Cheap MK-4. Is It Reliable? Vitamins 1
RobertJM A New Peat Inspired Blog Found Blogs 0
johnwester130 Found Marmalade Without Pectin In The UK Beverages, Fruits, Sugars 8
T Salvestrols, Nutrients Missing In Our Food, Activate Enzyme Found Only In Cancer Cells For Apoptosis Cancer 10
Beefcake Man Spent 35 Years Studying The Brains Of Serial Killers. Found Increased Serotonin Scientific Studies 34
meatbag PFAS Forever Chemicals Found In Food Supply By FDA Breaking News 8
ecstatichamster Molecular Biology What We Know And How We Found It Book Recommendations 1
D Lower Ceruloplasmin Found In Parkinson’s Scientific Studies 44
W After Much Research, I Have Finally Found A Way To Get Very Low PUFA Goat Milk Milk 71
cyclops Found This Clip Of Peat When Considering A New Supplement Supplements, Pharmaceutical Drugs 0
charlie A Statistically Strong Relationship Has Been Found Between The MMR Vaccine & Autism Vaccines 2
D Study Found Positive Correlation Between Iron And Total +free Testosterone, Higher T3, DHT Scientific Studies 20
T Glyphosate Found In All 5 Major Orange Juice Brands Fruit Juice 56
Hugh Johnson Microplastics Found In 90 Percent Of Table Salt Health 29
debored13 Protein Found Conducting Electricity For The First Time Articles & Scientific Studies 2
T Consuming High-fat Dairy Products Found To Make Lung Function In Smokers Even Worse Scientific Studies 1
T Unusually High Levels Of Herpesviruses Found In The Alzheimer’s Disease Brain Scientific Studies 0
D Possible Link Found Between Diabetes And Titanium Dioxide Scientific Studies 3
Badger Type Of Sugar Often Found In Ice Cream Leads To Deadly Gut Infection Ice Cream 16
H Found The Root Cause Of My Hairloss And Now Im Pissed Hair & Nails 27
Mito Scientists Think They Found A New Human Organ—a Fluid-filled “shock Absorber” Miscellaneous Health Discussions 0
D Where Is Good Reliable Glycine To Be Found ? Supplements, Pharmaceutical Drugs 9
Brian fitusi Found Pleny Of Info On This, No Need To Respond. Diet 0
haidut US Government Study Found Cellphones (EMF) Cause Brain And Heart Cancer Scientific Studies 0

Similar threads