Forskolin Raises CAMP & Activates Androgen Receptor

[TubZy]

Forskolin and derivatives as tools for studying the role of cAMP. - PubMed - NCBI
Activation of the Human Androgen Receptor through a Protein Kinase A Signaling Pathway

And also raises testosterone:
https://www.ncbi.nlm.nih.gov/pubmed/11500963

 

[Mathematician]

Interesting!!!

 

[bdawg]

@TubZy I did this research due to a lead from the anabolicmen forum and used to pop forskolin, but stopped when i found this:

From my understanding of the results of this study, in vitro forskolin increases certain forms of AR, but it also impairs certain AR receptors binding (by 40%): Forskolin-induced dephosphorylation of the androgen receptor impairs ligand binding. - PubMed - NCBI

Not sure what Peat's view is either

 

[TubZy]

@TubZy I did this research due to a lead from the anabolicmen forum and used to pop forskolin, but stopped when i found this:

From my understanding of the results of this study, in vitro forskolin increases certain forms of AR, but it also impairs certain AR receptors binding (by 40%): Forskolin-induced dephosphorylation of the androgen receptor impairs ligand binding. - PubMed - NCBI

Not sure what Peat's view is either

Interesting...I have used a 95% extract before for a few weeks and I definitely noticed an increase in fat loss and leaness.

 

[Stryker]

Interesting...I have used a 95% extract before for a few weeks and I definitely noticed an increase in fat loss and leaness.

Me too , very full muscles

 

[TubZy]

Me too , very full muscles

I want to get back on it, but my glycogen stores aren't fully restored yet so after I take it in the morning I feel weird later on in the day almost like a stress response type feeling but I do feel more androgenic.

 

[Such_Saturation]

estrogenic

 

[TubZy]

estrogenic

It's physical effects are androgenic and has some androgenic properties on paper, even if it has some mild estrogenic properties they are irrelevant and weak

 

[tankasnowgod]

estrogenic

Ah, man! Why do all these fun androgen boosting supplements all have to be estrogenic and junk?

 

[Such_Saturation]

Ah, man! Why do all these fun androgen boosting supplements all have to be estrogenic and junk?

You need testosterone to deal with stress... how else will you beat your enemy

if it has some mild estrogenic properties they are irrelevant and weak

@haidut

 

[TubZy]

You need testosterone to deal with stress... how else will you beat your enemy



@haidut

I asked Peat about it a while ago and he didn't mention anything about it being estrogenic, at least in a dangerous way. I still don't know how to fully respond/refute to your one word comments otherwise I would provide more info. The reason why I mentioned the glycogen stores in my earlier post is he mentioned it could imitate adrenaline.

 

[Such_Saturation]

I asked Peat about it a while ago and he didn't mention anything about it being estrogenic, at least in a dangerous way. I still don't know how to fully respond/refute to your one word comments otherwise I would provide more info. The reason why I mentioned the glycogen stores in my earlier post is he mentioned it could imitate adrenaline.

I don't know man, but it certainly felt estrogenic when I took it.

Direct effects of prolactin on corticosterone release by zona fasciculata-reticularis cells from male rats. - PubMed - NCBI
"...PRL stimulated the corticosterone release in a dose-dependent pattern in the ZFR cells from normal male rats. The cellular adenosine 3'-5'-cyclic monophosphate (cAMP) concentration positively correlated with PRL concentration in the presence of forskolin or 3-isobutyl-1-methylxanthine (IBMX). PRL enhanced the stimulatory effects of cAMP mimetic reagents, i.e., forskolin, 8-bromo-adenosine 3',5'-cyclic monophosphate (8-Br-cAMP), and IBMX on the release of corticosterone.

Here is one of the studies.
Forskolin up-regulates aromatase (CYP19) activity and gene transcripts in the human adrenocortical carcinoma cell line H295R. - PubMed - NCBI

P.S. good luck with the flood of pm's going crazy because you left the email address uncensored

 

[TubZy]

I don't know man, but it certainly felt estrogenic when I took it.





P.S. good luck with the flood of pm's going crazy because you left the email address uncensored

Are you under stress, overweight etc? It can increase testosterone which can aromatase into estrogen in a stressed environment. Most people I know have zero issues with it especially in an estrogenic sense, besides most people don't take it year round anyways just for cutting purposes until they get their desired weight/body fat.

I can see how estrogen could be raised if cortisol is raised since they are connected, but I guess if you want to be super safe, then take it in combo with androsterone, glycine, niacinamide, MB, K2 etc which all lower estrogen/cortisol.

 

[Such_Saturation]

Are you under stress, overweight etc? It can increase testosterone which can aromatase into estrogen in a stressed environment. Most people I know have zero issues with it especially in an estrogenic sense, besides most people don't take it year round anyways just for cutting purposes until they get their desired weight/body fat.

I can see how estrogen could be raised if cortisol is raised since they are connected, but I guess if you want to be super safe, then take it in combo with androsterone, glycine, niacinamide, MB, K2 etc which all lower estrogen/cortisol.

It was with artichoke extract but then I ran out of the artichoke and just took it by itself. Same effect, risk taking, flushing, anger, eye pressure etc.

 

[TubZy]

It was with artichoke extract but then I ran out of the artichoke and just took it by itself. Same effect, risk taking, flushing, anger, eye pressure etc.

Where did I ask about the exact supplement you took in my post? I asked if you were overweight/understress etc. which would increase aromtase activity- This is what I mean when I say I never understand your posts lol

 

[Such_Saturation]

Where did I ask about the exact supplement you took in my post? I asked if you were overweight/understress etc. This is what I mean when I say I never understand your posts lol

Oh my bad lol, no I was 180cm 73kg, and under stress yeah pretty much, but that's why I was trying supplements. I expect useful supplements to help me, not me help them.

 

[whit]

I want to get back on it, but my glycogen stores aren't fully restored yet so after I take it in the morning I feel weird later on in the day almost like a stress response type feeling but I do feel more androgenic.

Have you gotten back on it?
If so update us please.

 

[Douglas Ek]

Forskolin and derivatives as tools for studying the role of cAMP. - PubMed - NCBI
Activation of the Human Androgen Receptor through a Protein Kinase A Signaling Pathway

And also raises testosterone:
Stimulatory effect of lactate on testosterone production by rat Leydig cells. - PubMed - NCBI

Forskolin Increases Tyrosine Hydroxylase And Dopamine In Hypothalamus

Just created this post as i am recently looking into boosting dopamine specially in the hypothalamus and reducing serotonin overall.
Might be a good read for the forskoling diggers

 

[ddjd]

any updates on forskolin experiences? can anyone recommend a good brand

 

[LeeLemonoil]

http://doraziolab.uky.edu/publications/Original Research Articles/Spry et. al. 4-09 prolonged forskolin manuscript PCMR.pdf

200 micromol concentration of a 20%-Forskoli extract was used. Thats roughly 1 mg on 10g cream if DIY.


I stubled on that research by a recent press-release that shilled for a forskollin-based derivat that induces healthy tanning with most beneficial biomarkers of tanning without skin-destruction of UV-radiation. They claimed that inventing the derivat was necessry becuase Forskolin alone wasnt able to penetrate deeply enough into human skin. I dont believe that. Forskolin is fat-slouble and can also be helped along with penetration enhancer. So as the paper above describes, I think Forskolin is sufficient to achive "tanned" skin in a healthy manner.