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Forskolin Increases Tyrosine Hydroxylase And Dopamine In Hypothalamus

Discussion in 'Scientific Studies' started by Douglas Ek, Jan 8, 2019.

  1. Douglas Ek

    Douglas Ek Member

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    As we know the hypothalamus is the endocrine center of the brain controlling hormonal output. Dopamine stimulates the hypothalamus to signal a cascade of hormones that does good in the body like androgens and thyroid hormones while suppressing the bad ones like prolactin, cortisol, tsh etc which serotonin stimulate.
    So anything that would increase dopamine production specifically in the hypothalamus would be pro androgenic and metabolic.
    Forskolin increases the rate limiting dopamine enzyme tyrosine hydroxlyase in the hypothalamus thus increasin synthesis of dopamine from tyrosine in the hypothalamus and estrogen seems to do the opposite according to this study.

    Estradiol attenuates the forskolin-induced increase in hypothalamic tyrosine hydroxylase activity. - PubMed - NCBI

    Also seems to increase post synaptic receptors picking up dopamine which is probably due to the increased dopamine production correct me if im wrong.

    Molecular mechanisms underlying forskolin-mediated up-regulation of human dopamine D2L receptors. - PubMed - NCBI

    And it seems to get better as it increases dopamine but not acetylcholine which a lot of other dopamine boosters tend to do.

    Effects of forskolin on endogenous dopamine and acetylcholine release in rat neostriatal slices
     
  2. Frankdee20

    Frankdee20 Member

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    Acetylcholine antagonizes Dopamine in many instances (its inhibitory) so we don’t want that at all.
     
  3. OP
    Douglas Ek

    Douglas Ek Member

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    That was my point. But a lot of supplements specially the nootropic boosters tend to boost both acetylcholine and dopamine. But i think in the wrong parts of the brain. Inducing a stress response
     
  4. Frankdee20

    Frankdee20 Member

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    Good point, yes acetylcholine can be stimulatory or inhibitory depending where. Dopamine in the PFC is ideal, and the Mesolimbic VTA area even more.
     
  5. Cameron

    Cameron Member

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    Interesting another strong point for Forskolin
     
  6. Cameron

    Cameron Member

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    Forskolin-induced dephosphorylation of the androgen receptor impairs ligand binding. - PubMed - NCBI
     
  7. Cameron

    Cameron Member

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  8. OP
    Douglas Ek

    Douglas Ek Member

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  9. OP
    Douglas Ek

    Douglas Ek Member

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