Forgotten Treatment: Testosterone And Progesterone Prevent Cancer

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https://cancerres.aacrjournals.org/content/canres/5/7/426.full.pdf

Those who criticize the use of testosterone in women for the prevention of mammary cancer have pointed out the danger of masculinization and sterility, but the small doses now employed in conjunction with progesterone have not been sufficient to produce these effects.

Furthermore, the literature contains numerous reports on the beneficial action of testosterone propionate alone in large doses without any untoward results (3, 4, 14, 16).

It has been suggested in a previous article (8), therefore, that testosterone be given in prophylactic doses to women with a family history of cancer who complain of mammary disturbances.

No untoward result has been noted in 16 women who have received these injections at the hands of the author for over 6 years, and who previously had complained of pain, swelling, and tenseness in the mammary glands.

The synergistic effect of progesterone makes possible the reduction of testosterone. CONCLUSION

1. Subcutaneous injections of progesterone in 48 brother-to-sister bred RIII female mice between the ages of 2 and 6 months reduced the incidence of spontaneous mammary adenocarcinoma from 54 per cent to 16.6 per cent.

2. Subcutaneous injections of testosterone propionate with progesterone further reduced the incidence to 6.25 per cent in 48 treated female mice between 2 and 6 months of age, the progesterone acting as an adjuvant.

3. Preliminary subcutaneous injections of these two hormones did not prevent the growth of transplanted mouse carcinoma and sarcoma.

4. Spayed females injected with testosterone and progesterone did not develop any mammary tumors. One control spayed female developed a sarcoma of the lower jaw, apparendy unrelated to the experiment.

5. The injection of testosterone propionate and progesterone is suggested as a prophylactic measure in women with a family history of cancer.
 

LeeLemonoil

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1940s.
Is that before the first estrogen-based products for cancer treatment or other „therapeutic“ purposes were synthesized and patented? I think so.
 

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