Flouride's Interaction With Biological Enzymes / Dynamics

[Sativa]

I have read that the Flouride ion can damage many important enzymes, possibly somthing worth being aware of.

I feel that Flouride use might be contradictory when trying to maximise metabolism and biological coherence.

Molecular Mechanism of Fluoride Induced Oxidative Stress and Its Possible Reversal by Chelation Therapy
January 2013

Fluoride is able to exert powerful influences on various enzymes and endocrine gland functions that affect or control the status of oxidant/antioxidant systems in living organisms.

Fluoride has a dense negative charge and is biochemically very active compound lead direct effect on DNA due to strong affinity with uracil and amide bonds by –NH---F- interactions leads to genotoxicity.

Fluoride can combine stably with DNA by covalent bonding, affecting the normal structure of DNA, and induce the production of free radicals, which can damage DNA strands directly or by lipid peroxidation initiated by free radicals.

Fluoride may depress the DNA polymerase enzymes which might further affect the process of DNA replication or repair and thereby damage DNA.

Fluoride was reported to be an equivocal carcinogen by the National Cancer Institute Toxicological Program

Link: https://www.researchgate.net/public...nd_Its_Possible_Reversal_by_Chelation_Therapy

The inhibiting effect of Sodium flouride on the action of Lipase
A. S. Loevenhart and George Peirce
J. Biol. Chem. 1907 2: 397.

PDF is attached
(Direct link to PDF: http://www.jbc.org/content/2/5/397.full.pdf