Flavonoid Hesperidin Induces Synapse Formation And Improves Memory Performance

[Mito]

"While most of the evidences concerning flavonoids’ actions on the CNS refer to the long-term treatment or dietary intake of flavonoids, here, we shed light on the beneficial effects of these compounds in a short-term intervention. In this perspective, flavonoids present the potential to be useful as pharmacological drugs capable to directly modulate CNS function and repair. Collectively, we described hesperidin as a new molecule able to improve the recognition memory performance in healthy adult mice, an event accompanied by an increase in hippocampal synapse formation."

Flavonoid Hesperidin Induces Synapse Formation and Improves Memory Performance through the Astrocytic TGF-β1

 

[TreasureVibe]

Bump! Ray Peat spoke of hesperidin:



Hesperidin is also a strong prostaglandin e2 inhibitor according to some research.

 

[ddjd]

"While most of the evidences concerning flavonoids’ actions on the CNS refer to the long-term treatment or dietary intake of flavonoids, here, we shed light on the beneficial effects of these compounds in a short-term intervention. In this perspective, flavonoids present the potential to be useful as pharmacological drugs capable to directly modulate CNS function and repair. Collectively, we described hesperidin as a new molecule able to improve the recognition memory performance in healthy adult mice, an event accompanied by an increase in hippocampal synapse formation."

Flavonoid Hesperidin Induces Synapse Formation and Improves Memory Performance through the Astrocytic TGF-β1

In other words this study is saying TGF-b1 is a good thing?

 

[Mito]

In other words this study is saying TGF-b1 is a good thing?

They are saying hesperidin improved memory indirectly by increasing TGF-β1.

“The novel object recognition test (NOR) was used to evaluate memory performance of mice intraperitoneally treated with hesperidin 30 min before the training and again before the test phase. The direct effects of hesperidin on synapses and astrocytes were also investigated using in vitro approaches. Here, we described hesperidin as a new drug able to improve memory in healthy adult mice by two main mechanisms: directly, by inducing synapse formation and function between hippocampal and cortical neurons; and indirectly, by enhancing the synaptogenic ability of cortical astrocytes mainly due to increased secretion of transforming growth factor beta-1 (TGF-β1) by these cells. Our data reinforces the known neuroprotective effect of hesperidin and, by the first time, characterizes its synaptogenic action on the central nervous system (CNS), pointing astrocytes and TGF-β1 signaling as new cellular and molecular targets of hesperidin. Our work provides not only new data regarding flavonoid’s actions on the CNS but also shed light on possible new therapeutic alternative based on astrocyte biology.”

 

[Mito]

Hesperidin

Hesperidin Powder (Citrus aurantium Extract) at Bulk Supplements. What is Hesperidin Powder, When to take, health benefits, dosage, side effects, and customer reviews.

www.bulksupplements.com

 

[golder]

Any ideas why Ray speaks favorably on Hesperidin when many sources quote it as estrogenic? Does the anti nitric oxide effect outweigh the estrogenicity?