Nemo
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Quinine and quinoline derivatives delay brain destruction by prions.
Quinoline derivatives are therapeutic candidates for transmissible spongiform encephalopathies - PubMed
We previously reported that quinacrine inhibited the formation of an abnormal prion protein (PrPres), a key molecule in the pathogenesis of transmissible spongiform encephalopathy, or prion disease, in scrapie-infected neuroblastoma cells. To elucidate the structural aspects of its inhibiting...
pubmed.ncbi.nlm.nih.gov