Finasteride vs Progesterone

[AsuraAcademy]

So, finasteride works similar to progesterone just because it increases serum progesterone by reducing its conversion to Dihydroprogesterone. What if I just use oral progesterone which is available in my country for hair loss? What the recommended dosage for standalone progesterone?

 

[5a-DHP]

You could try it; there's very little information re: progesterone use for male pattern baldness online.
It would need to be taken in 3-4 times per day for 5ar inhibition given it's half-life.
I don't think finasteride works because it increases progesterone production though - the idea that prog -> 5aDHP being mediated by 5ar = fin increases serum prog is a rather mechanical view of the system; I would expect finasteride-induced estrogen excess to lead to a net decrease in progesterone production in a man.

 

[Charger]

As someone who has used both, I think they're pretty much the same thing.

Finasteride may have a stronger affinity for 5AR and may take longer to clear, but they both feel equally anti-androgenic in my experience.

 

[cupofcoffee]

As someone who has used both, I think they're pretty much the same thing.

Finasteride may have a stronger affinity for 5AR and may take longer to clear, but they both feel equally anti-androgenic in my experience.

an important thing to consider is that, while they both have an anti-androgenic effect, progesterone doesn't reduce allopregnanolone like finasteride does and it might even increase it which makes it much better IMO.

 

[AsuraAcademy]

an important thing to consider is that, while they both have an anti-androgenic effect, progesterone doesn't reduce allopregnanolone like finasteride does and it might even increase it which makes it much better IMO.

Yes that's what I am thinking. Also, think about all other good things from progesterone getting converted into DihydroProgesterone and doing good things in Brain. I don't think it's even anti-androgenic the dosage I am thinking of is like 1-2mg per day.

 

[AsuraAcademy]

an important thing to consider is that, while they both have an anti-androgenic effect, progesterone doesn't reduce allopregnanolone like finasteride does and it might even increase it which makes it much better IMO.

What's the dosage of progesterone you used and why?

 

[AsuraAcademy]

You could try it; there's very little information re: progesterone use for male pattern baldness online.
It would need to be taken in 3-4 times per day for 5ar inhibition given it's half-life.
I don't think finasteride works because it increases progesterone production though - the idea that prog -> 5aDHP being mediated by 5ar = fin increases serum prog is a rather mechanical view of the system; I would expect finasteride-induced estrogen excess to lead to a net decrease in progesterone production in a man.

I am thinking of taking it topically on my scalp. I am working on some formulation where the rate of absorption is slow making sure it still get into the scalp. So, I guess the problem with short half-life can be overcome. I am just dreaming about full head of hair ?. I read about skin has its own 5AR activity and if progesterone uses it then there will be no testosterone getting converted into DHT. All of these are just a theory with limited information I fed in my Brain. Also, I think progesterone can make skin soft or add some fat layer which will help with blood flow.

 

[cupofcoffee]

What's the dosage of progesterone you used and why?

i haven't used It myself, sorry.

 

[AsuraAcademy]

As someone who has used both, I think they're pretty much the same thing.

Finasteride may have a stronger affinity for 5AR and may take longer to clear, but they both feel equally anti-androgenic in my experience.

Hi what is the dosage you recommend for standalone progesterone usage?

 

[Charger]

Hi what is the dosage you recommend for standalone progesterone usage?

0mg.

 

[AsuraAcademy]

0mg.

Why? I have no other options. No pregnenolone in my country. Only progesterone.

 

[mrchibbs]

You could try it; there's very little information re: progesterone use for male pattern baldness online.
It would need to be taken in 3-4 times per day for 5ar inhibition given it's half-life.
I don't think finasteride works because it increases progesterone production though - the idea that prog -> 5aDHP being mediated by 5ar = fin increases serum prog is a rather mechanical view of the system; I would expect finasteride-induced estrogen excess to lead to a net decrease in progesterone production in a man.

I concur. Very little research because of the bias against a molecule which cannot be patented, and with a very short half life.

So it's not super practical to take, and requires multiple doses daily with few guidelines of how to proceed.

It is incredibly safe however, and I feel like the anti-androgenic effects could be countered with some extra DHEA, DHT or even testosterone (just a few mg daily as needed to feel best).

 

[5a-DHP]

So it's not super practical to take, and requires multiple doses daily with few guidelines of how to proceed.
It is incredibly safe however, and I feel like the anti-androgenic effects could be countered with some extra DHEA, DHT or even testosterone (just a few mg daily as needed to feel best).

I'm currently taking exogenous testosterone base four times per day (purely experimental; not trying to improve health) - once this experiment is concluded, I plan on co-administering progesterone alongside each dose to see if its anti-androgenic effects are countered in the presence of an androgen stronger than DHEA. If no anti-androgenic effects are experienced, I plan on going very high on the dose (again, purely for the sake of experiment) to see what, if any, effect it has on MPB.
Anecdotally, I have a friend who claims his masteron-induced hairloss ceased entirely upon implementing injectable progesterone to restore deficient serum levels back to the top of the physiological reference range.

 

[mrchibbs]

I'm currently taking exogenous testosterone base four times per day (purely experimental; not trying to improve health) - once this experiment is concluded, I plan on co-administering progesterone alongside each dose to see if its anti-androgenic effects are countered in the presence of an androgen stronger than DHEA. If no anti-androgenic effects are experienced, I plan on going very high on the dose (again, purely for the sake of experiment) to see what, if any, effect it has on MPB.
Anecdotally, I have a friend who claims his masteron-induced hairloss ceased entirely upon implementing injectable progesterone to restore deficient serum levels back to the top of the physiological reference range.

I wish you a lot of luck. If you're really going to give it a shot, you should make a thread to monitor your experience.

In the most successful trans stories of hair regrowth I've read, rectal progesterone (300-400mg daily) always seems to be involved, along with CPA/spiro and E2

 

[Archon]

0mg.

what about preg and dhea? be it internal or topical

 

[Andman]

I'm currently taking exogenous testosterone base four times per day (purely experimental; not trying to improve health) - once this experiment is concluded, I plan on co-administering progesterone alongside each dose to see if its anti-androgenic effects are countered in the presence of an androgen stronger than DHEA. If no anti-androgenic effects are experienced, I plan on going very high on the dose (again, purely for the sake of experiment) to see what, if any, effect it has on MPB.
Anecdotally, I have a friend who claims his masteron-induced hairloss ceased entirely upon implementing injectable progesterone to restore deficient serum levels back to the top of the physiological reference range.

Agree with @mrchibbs , cool experiment. please keep us updated!

 

[Gypsumking]

Any updates on this experiment?