Finally Cured From Post Finasteride Syndrome

Joined
Nov 16, 2012
Messages
1,100
Nope my proviron wasn't verified, maybe I'll test it. But from my research it should be legit.

I've had mine tested (it's from PPL which has a reputation for being 'flawless' here):

Test Report #24471.png

The Proviron is legit but the Testosterone base (which some people here on RPF used even orally) turned out to be crap, purity-wise:

Test Report #24470.png

So bottom-line... always test unless you are sure you are getting 100% pharma-grade products from big companies, and even then unless you know the vendor I'd test at least the first batch.
 

Mister

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Joined
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Messages
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I've had mine tested (it's from PPL which has a reputation for being 'flawless' here):

View attachment 43608

The Proviron is legit but the Testosterone base (which some people here on RPF used even orally) turned out to be crap, purity-wise:

View attachment 43609

So bottom-line... always test unless you are sure you are getting 100% pharma-grade products from big companies, and even then unless you know the vendor I'd test at least the first batch.
Very smart of you to test it.

Sucks the test isn't pure enough though...


@Matestube will be interested in these results too.
 
Joined
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Messages
1,100
Very smart of you to test it.

Sucks the test isn't pure enough though...


@Matestube will be interested in these results too.

Could very well be just a bad batch, it happens. I also have some of their DHT which I have not yet sent for testing but might do next month as the tests are quite costly.

I'm only out $25 on all that T so not the end of the world, but just goes to show you can't expect that because one product is fine, the others will be too.
 

Mister

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Anyone here used Tongkat Ali and/or black maca?

This guy says it helps for his fina sides:


Also seems part of a couple of recovery stories:

"Check light at the end, he tried clomid, did nothing, then he tried progesterone with testo boosters (Tongkat Ali), got cured."

And yesterday Deya said it was part of a regimen that cured a couple of PSSD and PFS patients of him.

So far I've also not found anything that points tongkat ali or black maca to be anti androgenic, so seems safe to me but also read it made some pfs cases worse...

And seesm Hans wrote some articles;


@Hans You sure Tongkat Ali is safe for us PFSers and isn't bad for DHT?
 
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Peatfan69

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Feb 26, 2018
Messages
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Anyone here used Tongkat Ali and/or black maca?

This guy says it helps for his fina sides:


Also seems part of a couple of recovery stories:

"Check light at the end, he tried clomid, did nothing, then he tried progesterone with testo boosters (Tongkat Ali), got cured."

And yesterday Deya said it was part of a regimen that cured a couple of PSSD and PFS patients of him.

So far I've also not found anything that points tongkat ali or black maca to be anti androgenic, so seems safe to me but also read it made some pfs cases worse...

And seesm Hans wrote some articles;


@Hans You sure Tongkat Ali is safe for us PFSers and isn't bad for DHT?
The theory behind test booster plus progesterone is that it increases both channels (5AR1 and 5AR2). This is similar to the TRT and progesterone route which most people say is a bandaid since TRT is used.
 

Mister

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The theory behind test booster plus progesterone is that it increases both channels (5AR1 and 5AR2). This is similar to the TRT and progesterone route which most people say is a bandaid since TRT is used.
What do you think about progesterone?

Found it to be part of some recoveries like these:

Progesterone treatment?


But I read progesterone also acts as an anti androgen? So I'm not sure if it's safe or not.

Found this from one of Hans's articles:

Progesterone​


Progesterone is always thought to be a female hormone, but men do also produce progesterone in the adrenals and testes. In fact, in males, progesterone influences spermiogenesis, sperm
capacitation, and testosterone biosynthesis in Leydig cells (R).


Progesterone has been shown to have potent anti-cortisol effects, as it calms the adrenals.
As a result, excess aldosterone is also reduced. Progesterone is also the body’s main estrogen antagonist and inhibits the estrogen-induced α1 and α2-adrenergic receptor increase (which is anti-erection) (R).


Progesterone also has a general suppressive effect on vascular smooth muscle contractility, possibly by lowering estrogen, α-adrenergic receptors, angiotensin and aldosterone.


So optimizing progesterone can boost erections on multiple fronts.


There isn’t much research on humans/men yet, but there are on animals, such as reptiles, mice and rats.


Although it’s not possible to extrapolate data obtained from laboratory animals to clinical cases, rodent studies have supported the notion that rats and humans possess analogous sexual behaviors that are altered similarly by neuroendocrine manipulations showing similarities that provide further evidence of the reliability of these models in the study of the mechanisms that govern sexual function (R).


So let’s discuss some of the animal research.


After castration, which tanks androgens, progesterone rescued sexual function in rats whereas estrogen was ineffective (R).


This study even shows that testosterone alone did not completely restore typical sexual responses in all males unless progesterone concentrations were elevated (R).


Interesting right?…


This study found that treating sleep-deprived rats with progesterone promoted erections (R). Sleep deprivation on its own caused an increase in progesterone and erections. You know that feel when you’re so tired and you get an annoying boner for a long period of time? Seems it’s generally due to overstimulation of the parasympathetic nervous system as well as an increase in progesterone.


Giving the sleep-deprived or progesterone treated animals a progesterone antagonist, RU486, significantly reduced the percentage of rats displaying erections compared to control rats, and reduced erection frequency as well (R).


Point being, progesterone could be very important for erections and libido.

 
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Cooper

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Guys, this is very complicated for me to talk but i will try my best. First off, im still on 500mg Test E and HCG and also added rectal Progesterone after reading the benefits. Libido is very nice but my Post Accutane Syndrome never interfered with my libido, yeah. I think that it clogged up some nerves or my prostate directly without affecting my brain chemistry.

Here is the thing and the thing i feel: Especially when i smoke some weed, i realize that my whole internal nerve network, especially the lower half of my body feels numb. It feels like peripheral neuropathy. I also read that Androgen Receptors play a part in this nervous system, but i don't have time or mental health to dive into research about all of this.

Has anyone feel the same? Here is how i can explain my numbness: My pelvic floor area feels CLOGGED UP and i can feel a DULL discomfort and a slight ache inside the pelvic floor area, more near the rectum. Feels like something is blocking there, and that causes the whole numb penis, testicles, PC muscles, orgasms for me.

I guess many of us should feel this? And also, i think this issues may related to my gut. When i press my gut with my fingertips and push them inwards, i can feel a discomfort as if i have GAS stuck there. Like as if i have a full bladder all the time and when i press my fingers there i can feel the tingly and dull sensation even though i just visited the toilet, makes sense?

Anyways, i feel like my numbness stems from the place inside my pelvic floor somehow and i don't know the exact root cause of it. Can someone help me out with this?
What i do as a meditation and to stay sane is that, i imagine sensations in my head thinking about sexual acts. And doing so, i can feel all those old sensations in my head before PAS, 8 years ago. I kept doing this over the years and that way i never forgot how a normal human should feels when the CLOGGED UP feeling goes away.

People get used to diseases and forget the healthier versions of themselves and the sensations, this might sound like kinda crazy but doing so, i still remember how should i feel objectively, this gives me hope but at the same time reminds me of WHAT I HAVE LOST. When i have sex with my GF, i barely feel the inside of her vagina.

I don't even feel the warmness there! Do every vagina should feel warm when you insert your penis there?
I sometimes feels slight warmness when i first insert it but then it goes away quickly, i get used to it fastly. I dunno if this is normal?

Sorry for this untidy text guys, but i really need some details and experiences from you.

I really don't understand why i experience this numbness. I did some gut tests and there was no inflammation except low levels of Akkermansia and Prevotella bacterias which i tried an amazing diet and supplements for it with no results. I also took Methylprednisolone to test my immune system with no results.

It feels like there is something CLOGGING me down there, inside the pelvic floor area, in between my legs. It is probably my prostate. One time a Urologist examined there with his finger and told me that it was bigger than normal and it had edemas as i talked about it in here before. So there is clearly something going on there. He told me my prostate is causing some blockage around the surrounding nerves. That's why i have all of these numb orgasms and erect penis SIZE LOSS, shape changes because nerves also control the BLOOD VESSELS and Smooth Muscle Contractions.


But i am not sure the root cause of this. Is my gut inflaming my prostate? Or did something else happen to my nerve health? I feel like there is a dull ache inside me when i ejaculate. It feels painful! I can't feel my penis when it is erect, nor i can feel the existence of my testicles without touching them. I can't even feel the urine flow inside my penis when i urinate in the toilet. It feels like im peeing sand.

I tried countless hormones and supplements to fix this over the years, im still gonna use T and HCG and stop it next month to see if smth resets itself.

There is this constant feeling of clogged uppness when i think about it, i can't feel relief when i pee, ejaculate or ahem, when i poo. (The sensations are just not there and i can feel it. And i can imagine in my head that how should i feel if i was healthy! God bless, i still didn't forget the amazing sensations because i kept reminded myself. Remembering is important to recover i think, but ofc it is not good to obsess about this.)

I feel like something is "squeezing my nerve netwrok" even my hands sometimes. It feels dull. But i don't have any tingliness or burning sensation anywhere in my body luckily.

You guys can relate to this? What kind of tests or specialists should i see for this? What should i do? I even tried two week water fasting. My balls (Scrotum fullness to be spesific.) get bigger but the numbness was still there.

@Mister @Lokzo @haidut
 
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Mister

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Messages
782


Allopregnanolone Counteracts Finasteride-induced Alterations in Gut Microbiota, According to New University of Milano Research​




Study marks first-ever demonstration of a successful PFS therapy in an animal mode​

 

TTorque

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Yet - there's still no good way of obtaining/taking allop, right? The drops from ideal have an extremely low half-life I believe(?)
 

Mister

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Messages
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Yet - there's still no good way of obtaining/taking allop, right? The drops from ideal have an extremely low half-life I believe(?)
Interesting article:


Palmitoylethanolamide (PEA) seems to be promising to improve allopregnanolone.

It is known that post-finasteride syndrome (PFS) patients suffer from treatment-resistant depression and anxiety. Researchers have found low levels of neurosteroids, including allopregnanolone, in the cerebrospinal fluid of post-finasteride syndrome patients.


Palmitoylethanolamide (PEA) is a substance naturally produced in many cell types in our bodies, including in very high concentrations in our brains. Over 60 years ago PEA was found in egg yolks and peanuts and determined to have anti-inflammatory and neuroprotective and analgesic properties.


By the mid-1990’s PEA’s mechanism of action was discovered and linked to its ability to induce the brain biosynthesis of neuroactive steroid hormones, including allopregnanolone. In mouse models PEA increased brain allopregnanolone levels and reduced anxiety-like and depression-like behaviors. This improvement was blocked by finasteride, which blocks the synthesis of allopregnanolone.



PEA molecule

It appears promising that treatment with PEA, by increasing allopregnanolone levels in PFS patients’ brains, could improve mood and reduce anxiety. PEA has been studied in 40 clinical trials involving 6000 subjects over the years and has shown a quite favorable risk/benefit ratio.


Doses have ranged between 1200mg and 3600mg per day without significant side effects. 30 mg/kg doses have been studied in children.


In the near future oral allopregnanolone analogs will be available to use in attempting to treat PFS patients. In the mean time ultra-micronized PEA can be obtained from Amazon for a reasonable cost.


Btw; very interesting old thread about PEA on propeciahelp, good read with a lot of interesting studies:

(@Cooper You're talking about your nerves and neuropathy right? Definitely read the studies in the thread. Palmitoylethanolamide (PEA) regulates many pathophysiological processes in the central nervous system)


Seems some tried it although for very short periods of time because it made them feel worse. But as many recoveries have shown this isn't necesserarily a bad thing, remember PAL's recovery with proviron and him stating he never felt so bad during his cycle...

Also found another thread and it also upregulates 5alpha reductase1:


you people may know that 5ar-1 is the main subtype in brain areas related to sexual development like mPoa


turns out this widely available supplement upregulates it by 97% even at very low dose

as well as increasing Allo/DHP and other neurosteroids


"Importantly, a single PEA EC50
dose normalized the expression of these proteins to the levels quantified in GH-control mice (PPAR-α: +109%, p<0.01; StAR: +339%, p<0.001; CYP11A1: +81%, p<0.01; 5α-RI: +97%,


This study provides novel neurobiological evidence that stimulation of PPAR-α by PEA induces the corticolimbic biosynthesis of Allo, an effect that is directly associated with the improvement of a PTSD-like phenotype in SI mice. Specifically, PEA reduced the expression of conditioned contextual fear, and facilitated extinction and extinction retention (Fig. 1). PEA also induced anxiolytic- and antidepressant-like effects in SI mice. Furthermore, the behavioral effects of PEA in SI mice related to normalization of down-regulated levels of Allo in hippocampus, amygdala, prefrontal cortex and the olfactory bulb. PEA also elevated Allo-S in the hippocampus"
 
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stoic

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Aug 21, 2020
Messages
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A few years have passed since I last took this poison. My sexual function is still compromised, but I believe this is due to accutane, which I took years before with even worse physical "side" effects.

On the upside: my cognitive function is now completely restored, and I now feel even more mentally capable than before taking those poisons. I say this as an encouragement to all the lurkers: never give up – healing is definitely possible.

While I can't pinpoint exactly what did it, I am fairly convinced it was the result of time and efforts spent on a low stress, androgen promoting, peat eating lifestyle.

As always, the most important thing is to help the body heal itself, and to avoid making the same mistakes in the future.
 

TTorque

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Messages
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USA, MI
A few years have passed since I last took this poison. My sexual function is still compromised, but I believe this is due to accutane, which I took years before with even worse physical "side" effects.

On the upside: my cognitive function is now completely restored, and I now feel even more mentally capable than before taking those poisons. I say this as an encouragement to all the lurkers: never give up – healing is definitely possible.

While I can't pinpoint exactly what did it, I am fairly convinced it was the result of time and efforts spent on a low stress, androgen promoting, peat eating lifestyle.

As always, the most important thing is to help the body heal itself, and to avoid making the same mistakes in the future.
How long do you roughly feel it took to somewhat restore your mental/cognitive abilities?
 

stoic

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Messages
271
How long do you roughly feel it took to somewhat restore your mental/cognitive abilities?
About two years, I think.

I took a three month course of proviron at the time, and that might have played a substantial role, but I am not really sure.
I started peating about two years ago and have been gradually changing my entire lifestyle and attitude since then, so I am inclined to believe that it was all those small changes that allowed my body to find the energy to heal and regenerate.

Still almost no feelings for and during sex, but I reckon that as my energy, strength and mood further improve, that part will also follow.
 

Mister

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Joined
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Messages
782
About two years, I think.

I took a three month course of proviron at the time, and that might have played a substantial role, but I am not really sure.
I started peating about two years ago and have been gradually changing my entire lifestyle and attitude since then, so I am inclined to believe that it was all those small changes that allowed my body to find the energy to heal and regenerate.

Still almost no feelings for and during sex, but I reckon that as my energy, strength and mood further improve, that part will also follow.
Seems libido is always or most of the time, the last thing to recover in pfs...
 

Cooper

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Messages
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About two years, I think.

I took a three month course of proviron at the time, and that might have played a substantial role, but I am not really sure.
I started peating about two years ago and have been gradually changing my entire lifestyle and attitude since then, so I am inclined to believe that it was all those small changes that allowed my body to find the energy to heal and regenerate.

Still almost no feelings for and during sex, but I reckon that as my energy, strength and mood further improve, that part will also follow.
Did you consume any alcohol while recovering?
 

Cooper

Member
Joined
Oct 12, 2020
Messages
351
Location
EU
Guys, this is very complicated for me to talk but i will try my best. First off, im still on 500mg Test E and HCG and also added rectal Progesterone after reading the benefits. Libido is very nice but my Post Accutane Syndrome never interfered with my libido, yeah. I think that it clogged up some nerves or my prostate directly without affecting my brain chemistry.

Here is the thing and the thing i feel: Especially when i smoke some weed, i realize that my whole internal nerve network, especially the lower half of my body feels numb. It feels like peripheral neuropathy. I also read that Androgen Receptors play a part in this nervous system, but i don't have time or mental health to dive into research about all of this.

Has anyone feel the same? Here is how i can explain my numbness: My pelvic floor area feels CLOGGED UP and i can feel a DULL discomfort and a slight ache inside the pelvic floor area, more near the rectum. Feels like something is blocking there, and that causes the whole numb penis, testicles, PC muscles, orgasms for me.

I guess many of us should feel this? And also, i think this issues may related to my gut. When i press my gut with my fingertips and push them inwards, i can feel a discomfort as if i have GAS stuck there. Like as if i have a full bladder all the time and when i press my fingers there i can feel the tingly and dull sensation even though i just visited the toilet, makes sense?

Anyways, i feel like my numbness stems from the place inside my pelvic floor somehow and i don't know the exact root cause of it. Can someone help me out with this?
What i do as a meditation and to stay sane is that, i imagine sensations in my head thinking about sexual acts. And doing so, i can feel all those old sensations in my head before PAS, 8 years ago. I kept doing this over the years and that way i never forgot how a normal human should feels when the CLOGGED UP feeling goes away.

People get used to diseases and forget the healthier versions of themselves and the sensations, this might sound like kinda crazy but doing so, i still remember how should i feel objectively, this gives me hope but at the same time reminds me of WHAT I HAVE LOST. When i have sex with my GF, i barely feel the inside of her vagina.

I don't even feel the warmness there! Do every vagina should feel warm when you insert your penis there?
I sometimes feels slight warmness when i first insert it but then it goes away quickly, i get used to it fastly. I dunno if this is normal?

Sorry for this untidy text guys, but i really need some details and experiences from you.

I really don't understand why i experience this numbness. I did some gut tests and there was no inflammation except low levels of Akkermansia and Prevotella bacterias which i tried an amazing diet and supplements for it with no results. I also took Methylprednisolone to test my immune system with no results.

It feels like there is something CLOGGING me down there, inside the pelvic floor area, in between my legs. It is probably my prostate. One time a Urologist examined there with his finger and told me that it was bigger than normal and it had edemas as i talked about it in here before. So there is clearly something going on there. He told me my prostate is causing some blockage around the surrounding nerves. That's why i have all of these numb orgasms and erect penis SIZE LOSS, shape changes because nerves also control the BLOOD VESSELS and Smooth Muscle Contractions.


But i am not sure the root cause of this. Is my gut inflaming my prostate? Or did something else happen to my nerve health? I feel like there is a dull ache inside me when i ejaculate. It feels painful! I can't feel my penis when it is erect, nor i can feel the existence of my testicles without touching them. I can't even feel the urine flow inside my penis when i urinate in the toilet. It feels like im peeing sand.

I tried countless hormones and supplements to fix this over the years, im still gonna use T and HCG and stop it next month to see if smth resets itself.

There is this constant feeling of clogged uppness when i think about it, i can't feel relief when i pee, ejaculate or ahem, when i poo. (The sensations are just not there and i can feel it. And i can imagine in my head that how should i feel if i was healthy! God bless, i still didn't forget the amazing sensations because i kept reminded myself. Remembering is important to recover i think, but ofc it is not good to obsess about this.)

I feel like something is "squeezing my nerve netwrok" even my hands sometimes. It feels dull. But i don't have any tingliness or burning sensation anywhere in my body luckily.

You guys can relate to this? What kind of tests or specialists should i see for this? What should i do? I even tried two week water fasting. My balls (Scrotum fullness to be spesific.) get bigger but the numbness was still there.

@Mister @Lokzo @haidut
Really no answers from anyone btw? Damn...
 

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