Finally Cured From Post Finasteride Syndrome

[Cooper]

I think im going to try Mifepristone. Jesus christ. I am still taking high quality gut health supplements after 15 days of water fast. It's been over a month now.

And i think im not gonna recover like this. However i still kept the scrotum fullness improvement from the water fast. That seems to be a permanent one which is nice.

I am still numb sexually. I hope Mife can do the final trick. Im not even researching things anymore, because it is a waste of time and science is a big lie. Big thanks to pharma industry, doctors and modern medicine.

Oh and yeah, i eat the clearest diet on earth and i still have horrible acne. Thanks to my genes too i guess? I just want a clear skin and my sexual function back. ***t, didn't realize how unfair the life actually is.

 

[Cooper]

Interesting bit I read in this study;

The effects of mesterolone, a male sex hormone in depressed patients (a double blind controlled study) - PubMed

Based on computer EEG (CEEG) profiles, in high doses, antidepressant properties of mesterolone, a synthetic androgen, were predicted. In a double-blind placebo controlled study, the clinical effects of 300-450 mg daily mesterolone were investigated in 52 relatively young (age range 26-53 years...

pubmed.ncbi.nlm.nih.gov

The effects of mesterolone, a male sex hormone in depressed patients (a double blind controlled study)​

"Patients with high testosterone levels prior to treatment seem to have had more benefit from mesterolone treatment than patients with low testosterone levels."


Reminds me of a guy who recovered in the big pfs whatsapp group. He recovered with one or a couple of proviron pills (25mg) but he had a (very) high base test level.

Also other PFS recoveries mentioned proviron (and other DHT derivatives) did nothing by itself but did when adding test. Also another recovery with proviron, he did HCG prior to doing proviron, the HCG probably increased his test levels.

Anyway just theorizing here.

And jesus christ to you too man. You should stop researching and try things already.

 

[Mister]

And jesus christ to you too man. You should stop researching and try things already.

I'm trying proviron right now actually.

And I hope your mife experiment will help but I believe your best bet is still the hormonal/steroid route. Even though you're PAS, it's practically the same to cure as PFS and PSSD imo. I know you also tried some cycles in the past but still many more options.

 

[CloudsInTheHead]

Interesting bit I read in this study;

The effects of mesterolone, a male sex hormone in depressed patients (a double blind controlled study) - PubMed

Based on computer EEG (CEEG) profiles, in high doses, antidepressant properties of mesterolone, a synthetic androgen, were predicted. In a double-blind placebo controlled study, the clinical effects of 300-450 mg daily mesterolone were investigated in 52 relatively young (age range 26-53 years...

pubmed.ncbi.nlm.nih.gov

The effects of mesterolone, a male sex hormone in depressed patients (a double blind controlled study)​

"Patients with high testosterone levels prior to treatment seem to have had more benefit from mesterolone treatment than patients with low testosterone levels."


Reminds me of a guy who recovered in the big pfs whatsapp group. He recovered with one or a couple of proviron pills (25mg) but he had a (very) high base test level.

Also other PFS recoveries mentioned proviron (and other DHT derivatives) did nothing by itself but did when adding test. Also another recovery with proviron, he did HCG prior to doing proviron, the HCG probably increased his test levels.

Anyway just theorizing here.

I'm looking forward to testing this once I get some actual proviron lol (my T is flagged high in many of my tests).

PFS (and depression) seems to mostly be a hormonal central nervous system issue, and since DHT doesn't really cross the blood-brain barrier, I've long assumed that proviron promotes DHT in those tissues by freeing up testosterone which can then enter the CNS and act/be converted to DHT. Obviously you need a bit of T to free up for that to be effective.

How's your proviron experiment going btw?

 

[Mister]

How's your proviron experiment going btw?

I just started last week but so far nothing to report. I'm also taking the lowest possible dose of 25mg/day, will probably go to 50mg or higher if I don't notice anything. Of course it's possible I have fake proviron lol, I'm not sure. Brand is called Unique Pharma.

Anyway, I'll keep you guys up to date. And my testosteron levels when I checked some time ago was lowish/normal.

But yeah proviron and other DHT derivatives are very interesting for us.

 

[wildworld1992]

I'm basically a cocktail of multiple things because I'm an idiot who thought everything (including AAS) was a free lunch.

I ruined my AR and ER, as well as my dopamine, while I'm certain SERMs gave me the varicocele that "coincidentally" appeared when my EQ dropped.

It's taken me absolutely years to reach an idea as to what's screwed up. Doubling my testosterone helped a little, although more so for my well-being.

Then I focused on DHT, which made me much more confident and also made PT-141 return my libido.

With that in mind, I took a D2 agonist (caber) to see if dopamine helped. It did a little but not too much.

I stumbled across @Lokzo's thread about how Ashwaghanda can cause PSSD, which explained a hell of a lot. Just over a year ago started high-dosing the herb, and within a month or two I felt nothing but numb.

At the time I were also eating 100g of cashew nuts, every single day because I thought carbs were causing insulin resistance. Ironic, right? My testosterone plummeted and I lost ALL sexual function; viagra did not work at all.

As much as D2 agonists are terrible for you and didn't really help sexual function (which proves serotonin is the issue with PSSD), its ability to lower prolactin (in combo with supplements and hcg) significantly increased my 5-AR. My beard is thick and sexy, and I'm finally getting hairy.

After coming off the D2 agonist I started taking 9-me-bc as recommended by Ryan from Livecortex, and guess what? Within a few days my libido went from non-existent to being almost bedridden from it.

So yeah I have been juggling multiple things at once, which probably isn't ideal. On top of that, I have been doing a lot of mobility work. My poor EQ basically feels like there's a weak connection at the pelvic floor, so I've also been working on that alongside fixing my anterior pelvic tilt.

I'm not the smartest guy alive and chemistry had always been my worst subject, but I'm definitely seeing results.

Usually high cortisol turns me completely robotic, but for the first time in a while I haven't become entirely apathetic. Tonight I'm sacrificing my balls for a hot bath to lower cortisol, but I'm really looking forward to seeing how I feel tomorrow.

The only thing I'm praying for is HCG to restore my EQ back to 100% over the next few weeks, which I'm now am convinced is down to some sort of ER problem, but I'm pretty optimistic.

Failing that, I'll probably try metformin as I've heard it can restore eNOS in the penis. Either way, over a year ago I told my GP I'm going to keep experimenting until I either die or fix the problem, because I REFUSE to live with the inability to ever form relationships and conceive.

Excuse the huge life-story; I know most people won't care but I needed to make my experience a little more clear so not to confused people.

Have you fixed all your problems?

 

[Mister]

DHT Stimulates Its Own Synthesis

The stress hormone estrogen is well-known for its ability to stimulate its own synthesis, resulting in a vicious circle. Some of the beneficial steroids like pregnenolone do the same, but for pretty much all others like T, cortisol, aldosterone, and even progesterone there is a feedback...

raypeatforum.com

The stress hormone estrogen is well-known for its ability to stimulate its own synthesis, resulting in a vicious circle. Some of the beneficial steroids like pregnenolone do the same, but for pretty much all others like T, cortisol, aldosterone, and even progesterone there is a feedback mechanism that prevents excess if working properly.
This study shows that DHT is another one of the protective steroids that have a positive feedback loop - i.e. it stimulates its own synthesis. So, the more androgenic your steroid profile is the more it will continue to be so. As far as I know, unless supplemented exogenously in very high doses, endogenous DHT will not downregulate its own synthesis even if its levels reach several times beyond the upper limit of the "normal" range.

 

[Matestube]

DHT Stimulates Its Own Synthesis

The stress hormone estrogen is well-known for its ability to stimulate its own synthesis, resulting in a vicious circle. Some of the beneficial steroids like pregnenolone do the same, but for pretty much all others like T, cortisol, aldosterone, and even progesterone there is a feedback...

raypeatforum.com

The stress hormone estrogen is well-known for its ability to stimulate its own synthesis, resulting in a vicious circle. Some of the beneficial steroids like pregnenolone do the same, but for pretty much all others like T, cortisol, aldosterone, and even progesterone there is a feedback mechanism that prevents excess if working properly.
This study shows that DHT is another one of the protective steroids that have a positive feedback loop - i.e. it stimulates its own synthesis. So, the more androgenic your steroid profile is the more it will continue to be so. As far as I know, unless supplemented exogenously in very high doses, endogenous DHT will not downregulate its own synthesis even if its levels reach several times beyond the upper limit of the "normal" range.

According to this theory, my DHT which has reached sky-high levels in the past, should be stuck in a never-ending forward-feedback loop and stay elevated.
Which is not the case.

 

[Mister]

“POST FINASTERIDE/5ARi SYNDROME CURE

I just thought I’d make this method public, I’m confident it works - I’ve used it with close to 15 clients now with complete remission.

Finasteride is a 5-alpha reductase inhibitor, it prevents the conversion of T > DHT via that enzyme. However that enzyme is also responsible for conversion of other hormones, namely neurosteroids in the brain. So by using a 5ARi you inhibit not only DHT but also allopregnenolone production - as well as other neurosteroids but we’ll focus on allopregnenolone.
Allopregnenolone is the 5-alpha reduced version of pregnenolone and is a potent GABA-A agonist. It has tremendous anxiolytic, anti-depressant and pro sleep potential. More importantly it’s a major regulator of libido.
Hence 5ARi > low allopregnenolone > libido issue > post-fina syndrome.

So why does libido not return upon cessation of finasteride/5ARi? Because steroidogenic acute regulatory protein (StAR) expression is semi-permanently down-regulated - I’ll explain more in a later post.

We can increase StAR expression via HCG. Low dose. 150iu every other day. After a few weeks libido (and mood, sleep, etc) will return, after a few months you can come off HCG if you wish.

Yes HCG, even at this low dose, will increase your e2 mildly - keep an eye on it if your prone to e2 sides.

Other 5AR inhibitors to avoid; dutasteride, saw palmetto, lions mane, coconut oil, accutane, pumpkin seed oil.

TLDR: if you have post fina syndrome take 150iu HCG EOD for 3 months.”

- quote olive

Anyone know this Olive guy?

 

[Mister]

Interesting (sexual) Recovery story of someone on the PFS whatsapp group:

Guy did a lot of bloodwork, even before taking fina. His test levels before taking fina was around 350-400 ng/dl so quite low but he said he felt perfectly fine on that level.

He took fina and got PFS, like most of us here. So he tried TRT and clomid first to try and recover and got his test level to 1300 ng/dl but he didn't feel any better. Later he did a cycle of HCG and got his test to 700 ng/dl and that cured his sexual symptoms completely. Maybe HCG fixed his androgen receptors? Who knows.

Don't know if he still has other symptoms that need to be fixed though but sexually he's completely recovered thanks to HCG.

 

[Mister]

Interesting video. HCG shelf life isn't long. After mixing, the potency of the HCG degrades quite rapidly.

So his tips; don't buy one bottle of 5000IU's but multiple lower dose bottles of example 1000IU's. Also better to use bacteriostatic water.

 

[Raltox]

Is Amazon an okay place to get bacteriostatic water?

For example: Amazon product ASIN B098KW7KQBView: https://www.amazon.com/Vaxxen-Labs-Reconstitution-Solution-Pack/dp/B098KW7KQB/

Some of the reviews are saying it came in a plastic bottle, instead of a glass one. How bad is that?

 

[Tyr1]

I thought I'd give you guys an update of what I've tried:

- Proviron cycle
-Heavy weights/ good food
-Test prop cycle with nolva and clomid pct
- Nolva and clomid cycle alone
- JoeKools HCG protocol for over 3 months
- Anabolic/androgenic year long cycle (blast/cruise) including test, tren, winny, dbol, halotestin, masteron, proviron, anadrol, NPP
- Fasting
- Estrogen injections and tablets

So far I am better off cognitively than I was but libido is right down and have ED. Caverject works, but whats the point without that feeling.

Estrogen was only thing that really improved sides - I thought of a hypothesis that if male horomone profile doesn't work, then female one might (estrogen and testostrone both enable drive, memory, dopamine to work)... trans who get pfs symptoms (there are many) get rid of them in time with estrogen and sometimes progesterone (extra libido) - their sexual libido often changes to
more female like with multiple orgasms, harder to reach, but more intense and all over the body. Their sexual preference often changes from heterosexual male to heterosexual female (massive difference between female attraction, compared to gay males for, example its more emotional and they aren't so attractive to gay looking guys)
What I want to try now?

Quick 8-10 week test prop cycle with dbol, masteron, proviron and hcg followed by PCT consisting of triptorelin initially, then clomid, nolva and HCG (to come off before finishing clomid/nolva) and then some time off... if I don't feel better, I will try one more dose of triptorelin


Last case scenario if this doesn't work, I'd feel I've tried all possible pathways and then so I'll be forced to go down the transgender route. This isn't as bad as it sounds - they have libido, good sex drive/feelings, cognitive function and can get good relationships.


What are your thoughts on this?

What else could I possibly try?

My thoughts after reading this thread are that HCG works if we have enough androgens and lots of luck.

What do you think from this thread?

Do we have enough anecdotal evidence to suggest the "best approach" for pfs?

How do I join the pfs whatsapp group?

Any other groups I should join?

 

[wildworld1992]

I think im going to try Mifepristone.

Did you try Mifepristone?

 

[Cooper]

Did you try Mifepristone?

Not yet maybe around June.

 

[Tyr1]

I think im going to try Mifepristone. Jesus christ. I am still taking high quality gut health supplements after 15 days of water fast. It's been over a month now.

And i think im not gonna recover like this. However i still kept the scrotum fullness improvement from the water fast. That seems to be a permanent one which is nice.

I am still numb sexually. I hope Mife can do the final trick. Im not even researching things anymore, because it is a waste of time and science is a big lie. Big thanks to pharma industry, doctors and modern medicine.

Oh and yeah, i eat the clearest diet on earth and i still have horrible acne. Thanks to my genes too i guess? I just want a clear skin and my sexual function back. ***t, didn't realize how unfair the life actually is.

Recommend any sources for this ru-486?

 

[Cooper]

Recommend any sources for this ru-486?8

I can share a contact with you from China. I bought it from there. You can join our water fast group on telegram and ask me there.

Fast Forward⏩

Support group for PAS- PSSD- PFS to recover fully.

t.me

 

[CloudsInTheHead]

I thought I'd give you guys an update of what I've tried:

- Proviron cycle
-Heavy weights/ good food
-Test prop cycle with nolva and clomid pct
- Nolva and clomid cycle alone
- JoeKools HCG protocol for over 3 months
- Anabolic/androgenic year long cycle (blast/cruise) including test, tren, winny, dbol, halotestin, masteron, proviron, anadrol, NPP
- Fasting
- Estrogen injections and tablets

So far I am better off cognitively than I was but libido is right down and have ED. Caverject works, but whats the point without that feeling.

Estrogen was only thing that really improved sides - I thought of a hypothesis that if male horomone profile doesn't work, then female one might (estrogen and testostrone both enable drive, memory, dopamine to work)... trans who get pfs symptoms (there are many) get rid of them in time with estrogen and sometimes progesterone (extra libido) - their sexual libido often changes to
more female like with multiple orgasms, harder to reach, but more intense and all over the body. Their sexual preference often changes from heterosexual male to heterosexual female (massive difference between female attraction, compared to gay males for, example its more emotional and they aren't so attractive to gay looking guys)
What I want to try now?

Quick 8-10 week test prop cycle with dbol, masteron, proviron and hcg followed by PCT consisting of triptorelin initially, then clomid, nolva and HCG (to come off before finishing clomid/nolva) and then some time off... if I don't feel better, I will try one more dose of triptorelin


Last case scenario if this doesn't work, I'd feel I've tried all possible pathways and then so I'll be forced to go down the transgender route. This isn't as bad as it sounds - they have libido, good sex drive/feelings, cognitive function and can get good relationships.


What are your thoughts on this?

What else could I possibly try?

My thoughts after reading this thread are that HCG works if we have enough androgens and lots of luck.

What do you think from this thread?

Do we have enough anecdotal evidence to suggest the "best approach" for pfs?

How do I join the pfs whatsapp group?

Any other groups I should join?

Is your estrogen normally low? How high did it get while you were supplementing (and how much were you taking)?

 

[Tyr1]

Is your estrogen normally low? How high did it get while you were supplementing (and how much were you taking)?

7.5mg per week of Estradiol Enanthate,
alongside 2mg tab dissolved sublingually each day... it takes a while to reach actual female levels, so I never would have got to that point over the month of use. If I was to eventually go down this pathway, I'd only use 7.5mg per week and gradually increase it if needed to reach female level. I used the tabs as a kickstart to the cycle, like a lot of people do with anabolic steroids.

I know from previous blood test that my testostrone and estrogen were in good range (for a male).

I've since started a test, dbol and HCG, but plan on acquiring hardcore androgens this week and I'll do around a 8-10 week cycle. I feel rubbish on this already unfortunately, but hopefully it works with the HCG to bring back sensitivity and relieve me from cognitive sides.

Have a browse of transgender anecdotes / posts. They all seem to get better in time with the female hormonal profile. I just thought the obvious - who, what, how and when.

They don't usually get erections back however they get strong orgasms over whole body and cognitive clarity (I guess why they often get surgery to create a vagina which leaves nerves behind). There are many lesbians out there, however sexual preference may change as often reported.

Wish us luck!

I have 12 vials of 5,000iu hcg. What dosage does everyone recommend with my cycle?

I used 2,500 yesturday, but that might be way more than needed.

If this doesn't work, then I think the estrogen pathway would be better for health and personal life.

 

[Mister]

I thought I'd give you guys an update of what I've tried:

- Proviron cycle
-Heavy weights/ good food
-Test prop cycle with nolva and clomid pct
- Nolva and clomid cycle alone
- JoeKools HCG protocol for over 3 months
- Anabolic/androgenic year long cycle (blast/cruise) including test, tren, winny, dbol, halotestin, masteron, proviron, anadrol, NPP
- Fasting
- Estrogen injections and tablets

So far I am better off cognitively than I was but libido is right down and have ED. Caverject works, but whats the point without that feeling.

Estrogen was only thing that really improved sides - I thought of a hypothesis that if male horomone profile doesn't work, then female one might (estrogen and testostrone both enable drive, memory, dopamine to work)... trans who get pfs symptoms (there are many) get rid of them in time with estrogen and sometimes progesterone (extra libido) - their sexual libido often changes to
more female like with multiple orgasms, harder to reach, but more intense and all over the body. Their sexual preference often changes from heterosexual male to heterosexual female (massive difference between female attraction, compared to gay males for, example its more emotional and they aren't so attractive to gay looking guys)
What I want to try now?

Quick 8-10 week test prop cycle with dbol, masteron, proviron and hcg followed by PCT consisting of triptorelin initially, then clomid, nolva and HCG (to come off before finishing clomid/nolva) and then some time off... if I don't feel better, I will try one more dose of triptorelin


Last case scenario if this doesn't work, I'd feel I've tried all possible pathways and then so I'll be forced to go down the transgender route. This isn't as bad as it sounds - they have libido, good sex drive/feelings, cognitive function and can get good relationships.


What are your thoughts on this?

What else could I possibly try?

My thoughts after reading this thread are that HCG works if we have enough androgens and lots of luck.

What do you think from this thread?

Do we have enough anecdotal evidence to suggest the "best approach" for pfs?

How do I join the pfs whatsapp group?

Any other groups I should join?

Damn Tyr, you tried a lot already. So your biggest issue is still libido, ed right?

I've seen guys recovering after a couple of cycles. So don't give up after one cycle, try it again later. You're next cycle looks good (although I would only add HCG as part of the pct but I know opinions differ on this though.)

You also said you felt better from estrogen right? Then why not to do a test only cycle? Drop the DHT derivatives. A test only cycle will also raise your estrogen.

And did you feel anything from those DHT derivatives?

I've also read many times some guys don't feel anything from oral/injectable DHT derivatives, especially without a test base. You can also try DHT gel/andractim. Many PFS cases recovered with this. Here's an interesting one I already posted itt a couple of times: PFS - Down-regulating Androgen Receptors with DHT

And last, please check you have good sources for the products you use, make sure they're legit.

Oh, and @Cooper posted a link to the PFS whatsapp group somewhere itt.