Finally Cured From Post Finasteride Syndrome

FinVictim

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I have all the common PFS symptoms. Brain Fog,Flat, emotion less, lay in bed all day staring, no motivation, no libido, no erections, numb **** etc.

HAve been like this most of my adult life, I did take accutane aged around 16 and maybe my life has sucked since then (39 now). I have up and down periods, not all awful. Have relied heavily on Viagra but doesnt work so good any more.

Something to be aware of, and I think this would apply to most "flat emotion type" PFS sufferers, is how getting all the emotions "normal" people have (back) would be extremely overwhelming and might cause anxiety in many of us.

I've had PFS for almost 2 years now but I can clearly remember how intense life was with all the emotions and androgenic drive (including ego, wanting to be accepted/liked etc). Suddenly getting all of this back would undoubtedly be extremely hard to handle too.
 

Mister

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Of particular interest, androgen receptor expression (AR) was found to be significantly higher in patients compared to controls, in the absence of differences in serum markers indicating AR activity or trinucleotide repeat variation. The authors suggested that AR overexpression in response to an androgen-deficient state may negatively affect multiple tissues throughout the body, could be responsible for the sexual symptoms of Post-Finasteride Syndrome, and - if overexpressed in other tissues - may be involved in other symptomatic domains, including cognitive symptoms.


Anyone know what we can do to down regulate the AR? I assume taking androgens like proviron, masteron,... in higher doses? Any other methods?
 
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Of particular interest, androgen receptor expression (AR) was found to be significantly higher in patients compared to controls, in the absence of differences in serum markers indicating AR activity or trinucleotide repeat variation. The authors suggested that AR overexpression in response to an androgen-deficient state may negatively affect multiple tissues throughout the body, could be responsible for the sexual symptoms of Post-Finasteride Syndrome, and - if overexpressed in other tissues - may be involved in other symptomatic domains, including cognitive symptoms.


Anyone know what we can do to down regulate the AR? I assume taking androgens like proviron, masteron,... in higher doses? Any other methods?


Androgens seem to upregulate AR, not downregulate it.

Then again, so does removing androgens.


The situation is not clear cut at all.
 

Mister

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Androgens seem to upregulate AR, not downregulate it.

Then again, so does removing androgens.


The situation is not clear cut at all.
I see, find it interesting how restarting fina helped some. (I don't recommend it of course)


Also notice how mods censor information by making this thread invisible in search results... I made a print screen, you never know when they decide to delete this info forever.

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That sounds strikingly similar to a username that Kevin Mann typically uses on hair loss Discords and forums (he went by WhiteWolfKevin or some ***t like that). Could be his sad attempt at trolling or deliberately hurting people.
 

Mister

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That sounds strikingly similar to a username that Kevin Mann typically uses on hair loss Discords and forums (he went by WhiteWolfKevin or some ***t like that). Could be his sad attempt at trolling or deliberately hurting people.
Yeah could be, you never know with that psycho.

But I checked his older messages and I don't think he's fake, I've also read a couple of guys who claimed to have gotten better from retaking fina. Of course a big gamble I would never take.
 
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Yeah could be, you never know with that psycho.

But I checked his older messages and I don't think he's fake, I've also read a couple of guys who claimed to have gotten better from retaking fina. Of course a big gamble I would never take.

It would almost certainly boost my sex drive just by raising free T, but that's not really my primary concern.

Anyone here try mifepristone?
 

maillol

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I haven't read this whole thread but has anyone considered that it might be to do with cortisol rather than dht? Inhibiting 5AR is going to raise cortisol levels which your body will get desensitised to, then when you stop taking the 5ar inhibitor you will basically have cortisol insufficiency. I've never taken finasteride but it was just an idea i had after recently noticing that using a glucocorticoid inhaler increases my libido.
 

FinVictim

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I haven't read this whole thread but has anyone considered that it might be to do with cortisol rather than dht? Inhibiting 5AR is going to raise cortisol levels which your body will get desensitised to, then when you stop taking the 5ar inhibitor you will basically have cortisol insufficiency. I've never taken finasteride but it was just an idea i had after recently noticing that using a glucocorticoid inhaler increases my libido.

Yeah, great thought, thanks for the suggestion. Could theoretically be the case but the majority of PFS victims have completely normal cortisol / ACTH stimulation tests. Many have experimented with corticosteroids without any improvement.
 
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I actually have some corticosteroids in the mail along with a cortisol test, so I'll let you guys know what I find (that's also partially why I was asking about mifepristone).
 

Mister

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HCG is also very good for neurosteroids;






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T

TheBeard

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HCG is also very good for neurosteroids;





Taking straight up pregnenolone and dhea may be just as good if not better without the unknown risk of injecting female urine derivatives.
 

Mister

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Taking straight up pregnenolone and dhea may be just as good if not better without the unknown risk of injecting female urine derivatives.
HCG is just LH, it being derived from the urine from pregnant women doesn't make it bad or risky. Atleast if you buy from a legit source. And HCG is known for many decades, it's not dangerous at all in normal dosages.

Also HCG does much more than what pregnenolone and dhea do.

 

Mister

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First of all, significantly raising testosterone levels. From what I've read pregnenolone and dhea therapy isn't as efficient as HCG in improving most neurosteroids, etc.

It's why most endocrinologists don't just prescribe DHEA supps for example.
 
T

TheBeard

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First of all, significantly raising testosterone levels. From what I've read pregnenolone and dhea therapy isn't as efficient as HCG in improving most neurosteroids, etc.

It's why most endocrinologists don't just prescribe DHEA supps for example.

In case of secondary hypogonadism HCG does restore testosterone to normal levels.
You could also take straight up testosterone.

What else?
 

Mister

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You are the own who said "much more".
I was expecting more than the obvious "HCG raises testosterone".
As I said, HCG seems much more efficient at raising all cascading hormones, neurosteroids than just taking DHEA supplements. Atleast from what I read.
 

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