Philomath
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We validated that A250, a highly purified fraction of fermented wheat germ extract (FWGE), increases the carbon flux into the mitochondria, the expression of key elements of the Krebs cycle and oxidative phosphorylation (OXPHOS). The increased respiratory chain activity is related to the mitochondria’s ability to release cytochrome c into the cytosol, which triggers the apoptotic cascade. The 68% tumor growth inhibitory effect observed in the murine melanoma study is related to this effect,
This study is significant, as it shows that a highly concentrated form of FWGE is an effective agent that increases normal mitochondrial functionality.
Conclusion
Here we demonstrate that Fraction A250, a highly concentrated form of the active compounds of FWGE, changes the acidic environment by reducing lactic acid production and reprograms cellular metabolism away from the Warburg effect to increase mitochondrial carbon flux and oxidation. We also show that A250 increased the permeability of the mitochondrial outer membrane, leading to the release of cytochrome c into the cytosol. Cytochrome c has a significant role in intrinsic, mitochondria-mediated apoptosis, and it amplifies apoptotic signals.
in addition to initiating apoptosis through mitochondria, A250 has an active role in nutrient deprivation in cancer cells. As our results indicate, the effect of A250 on mitochondrial function reduces tumor growth in vivo and extends OS. In the 14-day treatment, the mice did not show any signs of toxicity, and pathological examination of the liver tissue validated that A250 had no toxic effect on normal tissue.
Cancer has been considered as Mitochondriopathy. Therefore, restoration of mitochondrial biology in a way that activates the Krebs’ cycle and manage apoptotic machinery might result in a breakthrough in the field of cancer medicine. One of those approach is that Schwartz et al., and enhancing apoptosis.
We validated that A250, a highly purified fraction of fermented wheat germ extract (FWGE), increases the carbon flux into the mitochondria, the expression of key elements of the Krebs cycle and oxidative phosphorylation (OXPHOS). The increased respiratory chain activity is related to the mitochondria’s ability to release cytochrome c into the cytosol, which triggers the apoptotic cascade. The 68% tumor growth inhibitory effect observed in the murine melanoma study is related to this effect,
This study is significant, as it shows that a highly concentrated form of FWGE is an effective agent that increases normal mitochondrial functionality.
Conclusion
Here we demonstrate that Fraction A250, a highly concentrated form of the active compounds of FWGE, changes the acidic environment by reducing lactic acid production and reprograms cellular metabolism away from the Warburg effect to increase mitochondrial carbon flux and oxidation. We also show that A250 increased the permeability of the mitochondrial outer membrane, leading to the release of cytochrome c into the cytosol. Cytochrome c has a significant role in intrinsic, mitochondria-mediated apoptosis, and it amplifies apoptotic signals.
in addition to initiating apoptosis through mitochondria, A250 has an active role in nutrient deprivation in cancer cells. As our results indicate, the effect of A250 on mitochondrial function reduces tumor growth in vivo and extends OS. In the 14-day treatment, the mice did not show any signs of toxicity, and pathological examination of the liver tissue validated that A250 had no toxic effect on normal tissue.
Cancer has been considered as Mitochondriopathy. Therefore, restoration of mitochondrial biology in a way that activates the Krebs’ cycle and manage apoptotic machinery might result in a breakthrough in the field of cancer medicine. One of those approach is that Schwartz et al., and enhancing apoptosis.