methylenewhite
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Modulation of Swarming and Virulence by Fatty Acids through the RsbA Protein in Proteus mirabilis
After sensing external signals, Proteus mirabilis undergoes a multicellular behavior called swarming which is coordinately regulated with the expression of virulence factors. Here we report that exogenously added fatty acids could act as signals to regulate swarming in P. mirabilis. Specifically, while oleic acid enhanced swarming, some saturated fatty acids, such as lauric acid, myristic acid, palmitic acid, and stearic acid, inhibited swarming. We also found that expression of hemolysin, which has been shown to be coordinately regulated with swarming, was also inhibited by the above saturated fatty acids.
Modulation of Swarming and Virulence by Fatty Acids through the RsbA Protein in Proteus mirabilis
Through a structure-activity relationship study of free FAs, bactericidal effect was identified mainly for polyunsaturated FAs, whereas QSI activity was restricted to SAFA of chains 12-18 carbon atoms in length. These data correlate with a possible interaction suggested by molecular docking analysis of lauric, myristic, and stearic acids with the CviR protein. Our study highlights the antiquorum sensing potential of SAFA, which may be future antivirulence therapeutic agents for the treatment of bacterial infections.
Antiquorum Sensing Activity of Seed Oils from Oleaginous Plants and Protective Effect During Challenge with Chromobacterium violaceum. - PubMed - NCBI
My amateur oversimplified speculation. SFAs turn off environmental ques and it could be extrapolated up to human body<>environment interactions level. It correlates with cortisol and ACTH lowering activities of SFA and PUFA amplification of stress responses. Mitochondria is believed to be an ancient bacteria after all.
Update.
Our study highlights the antiquorum sensing potential of SAFA, which may be future antivirulence therapeutic agents for the treatment of bacterial infections
SFA inhibits hostile behavior and swarming. No PUFA no hostility. I guess if we can even speculate on global scale of human behavior. If it's true we are coming to violence "apocalypse" with all this PUFA loaded veg oils.
After sensing external signals, Proteus mirabilis undergoes a multicellular behavior called swarming which is coordinately regulated with the expression of virulence factors. Here we report that exogenously added fatty acids could act as signals to regulate swarming in P. mirabilis. Specifically, while oleic acid enhanced swarming, some saturated fatty acids, such as lauric acid, myristic acid, palmitic acid, and stearic acid, inhibited swarming. We also found that expression of hemolysin, which has been shown to be coordinately regulated with swarming, was also inhibited by the above saturated fatty acids.
Modulation of Swarming and Virulence by Fatty Acids through the RsbA Protein in Proteus mirabilis
Through a structure-activity relationship study of free FAs, bactericidal effect was identified mainly for polyunsaturated FAs, whereas QSI activity was restricted to SAFA of chains 12-18 carbon atoms in length. These data correlate with a possible interaction suggested by molecular docking analysis of lauric, myristic, and stearic acids with the CviR protein. Our study highlights the antiquorum sensing potential of SAFA, which may be future antivirulence therapeutic agents for the treatment of bacterial infections.
Antiquorum Sensing Activity of Seed Oils from Oleaginous Plants and Protective Effect During Challenge with Chromobacterium violaceum. - PubMed - NCBI
My amateur oversimplified speculation. SFAs turn off environmental ques and it could be extrapolated up to human body<>environment interactions level. It correlates with cortisol and ACTH lowering activities of SFA and PUFA amplification of stress responses. Mitochondria is believed to be an ancient bacteria after all.
Update.
Our study highlights the antiquorum sensing potential of SAFA, which may be future antivirulence therapeutic agents for the treatment of bacterial infections
SFA inhibits hostile behavior and swarming. No PUFA no hostility. I guess if we can even speculate on global scale of human behavior. If it's true we are coming to violence "apocalypse" with all this PUFA loaded veg oils.
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