Kelj
Member
- Joined
- Jan 4, 2019
- Messages
- 299
Biochemistry of adipose tissue: an endocrine organ
It is time we start respecting our fat. Fat cells are not a mere repository for excess energy. The above paper has this to say:
"Adipose tissue is no longer considered to be an inert tissue that stores fat. This tissue is capable of expanding to accommodate increased lipids through hypertrophy of existing adipocytes and by initiating differentiation of pre-adipocytes."
"As an endocrine organ, adipose tissue is responsible for the synthesis and secretion of several hormones."
"This tissue is no longer considered to be an inert tissue that just stores fat [1]. Adipose tissue is a metabolically dynamic organ..."
"It is now generally recognized that adipose tissue is an important organ of a complex network that participates in the regulation of a variety of quite diverse biological functions"
"white adipose tissue's.....extensive distribution in the body, involving, or infiltrating, almost the entire region subcutaneously by organs and hollow viscera of the abdominal cavity or mediastinum and several muscle groups, for which it offers mechanical protection, softening the impact of shocks and allowing appropriate sliding of muscle bundles, one on the other, without compromising their functional integrity [2, 4]. Because it is an excellent thermal insulator and has a wide distribution, including the dermis and subcutaneous tissue, it plays an important role maintaining body temperature [5]. By this ability to accumulate and provide energy when necessary, it assumes the status of the most important buffering system for lipid energy balance"
"White adipose tissue may represent the largest endocrine tissue of humans. Its pleiotropic nature is based on the ability of fat cells to secrete numerous hormones, growth factors, enzymes, cytokines, complement factors and matrix proteins. Adipose tissue also expresses receptors for most of these factors that are implicated in the regulation of many processes including food intake, energy expenditure, metabolism homeostasis, immunity and blood pressure homeostasis [7, 13]."
"Adipose tissue is dynamically involved in cell function regulation through a complex network of endocrine (signals travel through the circulatory system to reach all parts of the body), paracrine (signals sent only to cells in the vicinity of the cell station), and autocrine (only affecting cells that are the same type) signals that influence the response of many tissues, including hypothalamus, pancreas, liver, skeletal muscle, kidneys, endothelium, and the immune system, among others. This secretory nature has prompted the view of white adipose tissue as an extremely active endocrine tissue [5]."
To start respecting this organ and the protection it affords us, we need to look at what the science really shows about fat and obesity. As it says here:
Obesity Basic Facts I — The Eating Disorder Institute
"Obesity is not a disease. It is not a marker of ill health or lowered life expectancy. The chronic conditions that are weakly correlated with “obesity” exist at all weights and are more likely to cause death in those who are average or below average weight than those who are above average weight."
"In the past 25 years alone, teenagers have increased overall 1% in height and 4% in weight on average. In that same time period, life expectancy increased on average by 6 years in most developed nations, which in Canada translated to a 7% increase in life expectancy from 1980 to 2005 (National Statistics). Rather interesting correlations, no?"
"And why did our populations remain thinner and shorter than today, despite improved nutrition after the Second World War? Smoking rates— that coincidentally began declining 25 years ago.39,40,41 Smoking suppressed reaching optimal weight and generated massive spike in disease states. In fact cardiovascular disease and mortality rates have dropped with smoking rates despite the questionably touted correlation of weight and heart disease."
"Weight is not a measure of health. Weight is not a predictor of sustaining your health either."
It is time we start respecting our fat. Fat cells are not a mere repository for excess energy. The above paper has this to say:
"Adipose tissue is no longer considered to be an inert tissue that stores fat. This tissue is capable of expanding to accommodate increased lipids through hypertrophy of existing adipocytes and by initiating differentiation of pre-adipocytes."
"As an endocrine organ, adipose tissue is responsible for the synthesis and secretion of several hormones."
"This tissue is no longer considered to be an inert tissue that just stores fat [1]. Adipose tissue is a metabolically dynamic organ..."
"It is now generally recognized that adipose tissue is an important organ of a complex network that participates in the regulation of a variety of quite diverse biological functions"
"white adipose tissue's.....extensive distribution in the body, involving, or infiltrating, almost the entire region subcutaneously by organs and hollow viscera of the abdominal cavity or mediastinum and several muscle groups, for which it offers mechanical protection, softening the impact of shocks and allowing appropriate sliding of muscle bundles, one on the other, without compromising their functional integrity [2, 4]. Because it is an excellent thermal insulator and has a wide distribution, including the dermis and subcutaneous tissue, it plays an important role maintaining body temperature [5]. By this ability to accumulate and provide energy when necessary, it assumes the status of the most important buffering system for lipid energy balance"
"White adipose tissue may represent the largest endocrine tissue of humans. Its pleiotropic nature is based on the ability of fat cells to secrete numerous hormones, growth factors, enzymes, cytokines, complement factors and matrix proteins. Adipose tissue also expresses receptors for most of these factors that are implicated in the regulation of many processes including food intake, energy expenditure, metabolism homeostasis, immunity and blood pressure homeostasis [7, 13]."
"Adipose tissue is dynamically involved in cell function regulation through a complex network of endocrine (signals travel through the circulatory system to reach all parts of the body), paracrine (signals sent only to cells in the vicinity of the cell station), and autocrine (only affecting cells that are the same type) signals that influence the response of many tissues, including hypothalamus, pancreas, liver, skeletal muscle, kidneys, endothelium, and the immune system, among others. This secretory nature has prompted the view of white adipose tissue as an extremely active endocrine tissue [5]."
To start respecting this organ and the protection it affords us, we need to look at what the science really shows about fat and obesity. As it says here:
Obesity Basic Facts I — The Eating Disorder Institute
"Obesity is not a disease. It is not a marker of ill health or lowered life expectancy. The chronic conditions that are weakly correlated with “obesity” exist at all weights and are more likely to cause death in those who are average or below average weight than those who are above average weight."
"In the past 25 years alone, teenagers have increased overall 1% in height and 4% in weight on average. In that same time period, life expectancy increased on average by 6 years in most developed nations, which in Canada translated to a 7% increase in life expectancy from 1980 to 2005 (National Statistics). Rather interesting correlations, no?"
"And why did our populations remain thinner and shorter than today, despite improved nutrition after the Second World War? Smoking rates— that coincidentally began declining 25 years ago.39,40,41 Smoking suppressed reaching optimal weight and generated massive spike in disease states. In fact cardiovascular disease and mortality rates have dropped with smoking rates despite the questionably touted correlation of weight and heart disease."
"Weight is not a measure of health. Weight is not a predictor of sustaining your health either."