Famotadine To Treat Covid_19

[Oraganic4me]

I heard that some researchers from Columbia NYC have said that Famotodine is being used to treat Covid-19 patients.
Famotidine can bind to something called papainlike protease, which is important for viral replication.
I suppose it will be the new Hydroxychloroquine soon. Any thoughts?

 

[haidut]

I heard that some researchers from Columbia NYC have said that Famotodine is being used to treat Covid-19 patients.
Famotidine can bind to something called papainlike protease, which is important for viral replication.
I suppose it will be the new Hydroxychloroquine soon. Any thoughts?

I think its main effects are through lowering serotonin and enhancing glycogen synthesis by inhibiting GSK-3. The latter mechanism is known to be broadly therapeutic and work even for things like cancer, diabetes, Alzheimer, etc. Of course, the medical industry will never come out with a claim that lowering serotonin is therapeutic for viral conditions as that would decimate the SSRI sales and likely trigger massive lawsuits as lawyers will quickly figure out that they can make an argument for SSRI drugs contributing to the viral pathology and/or making it worse. So, they invented another obscure mechanism as an explanation of the benefits from famotidine.

 

[Grapelander]

New York hospitals are studying a common heartburn drug as treatment for Covid-19
People are buying up a heartburn medicine that's being tested as a coronavirus treatment, leading to shortages
Coronavirus treatment: NY hospitals quietly testing heartburn drug famotidine

 

[Oraganic4me]

I think its main effects are through lowering serotonin and enhancing glycogen synthesis by inhibiting GSK-3. The latter mechanism is known to be broadly therapeutic and work even for things like cancer, diabetes, Alzheimer, etc. Of course, the medical industry will never come out with a claim that lowering serotonin is therapeutic for viral conditions as that would decimate the SSRI sales and likely trigger massive lawsuits as lawyers will quickly figure out that they can make an argument for SSRI drugs contributing to the viral pathology and/or making it worse. So, they invented another obscure mechanism as an explanation of the benefits from famotidine.

Very insightful... Thank you.

 

[yerrag]

Famotidine can bind to something called papainlike protease,

So, they invented another obscure mechanism as an explanation of the benefits from famotidine.

Glad Trump did not mention this.

Or people will be dying of eating papaya, and Trump gets dumped on by some forum members again.

 

[haidut]

Inhibition of carbonic anhydrase is probably also highly beneficial, considering the recent studies showing COVID-19 patients have hypoxia that pure O2 treatment actually makes worse.
Famotidine Inhibits Carbonic Anhydrase (CA)

Hey @charlie - maybe we can get this thread merged with the one below?
https://raypeatforum.com/community/threads/famotidine-for-covid-19.34107

 

[Mito]

More Evidence Heartburn Drug May Help COVID-19 Patients
— Another observational study adds fuel to the fire, but more research is needed

“More data from observational studies, this time in hospitalized patients, indicated that famotidine (Pepcid AC), which is used to treat heartburn, was associated with improved clinical outcomes in COVID-19 patients.

Use of famotidine in a small group of 83 patients was associated with a lower risk of in-hospital mortality and a combined outcome of death and intubation, reported Jeffrey Mather, MS, of Hartford Hospital in Connecticut, and colleagues.

Moreover, famotidine use was also associated with lower levels of serum markers indicating severe disease, the authors wrote in the American Journal of Gastroenterology.

Famotidine is a histamine-2 receptor antagonist. The authors noted the mechanism by which famotidine might improve COVID-19 outcomes is currently unknown, but hypothesized it might work via "inverse-agonism" of the histamine-2 receptor, which implies SARS-CoV-2 is "at least partially mediated by pathological histamine release," the authors said.”

https://www.medpagetoday.com/infectiousdisease/covid19/88119