Extremely High Cortisol

[Nicole Carter]

I’ve been eating Peat style for 5 months, after 2 1/2 years carnivore (used to heal colitis) but my cortisol is still extremely high as found on a 24 hour urinalysis. Could it be high from the diet? How long does it take to recover? I’m also taking 1/2 tab of cynomel daily, tocovit, ashwaganda and progesterone during Luteal phase.

 

[haidut]

I’ve been eating Peat style for 5 months, after 2 1/2 years carnivore (used to heal colitis) but my cortisol is still extremely high as found on a 24 hour urinalysis. Could it be high from the diet? How long does it take to recover? I’m also taking 1/2 tab of cynomel daily, tocovit, ashwaganda and progesterone during Luteal phase.

High cortisol is a known result of being on the carnivore diet for extended period of time. If several tests across say 2-3 months keep showing elevated cortisol numbers you may want to consider pharmacological interventions to lower it. Cyproheptadine seems a good choice as it has been successfully used to treat even Cushing disease. Progesterone in doses of 50mg or higher also seems to lower excess cortisol.

Effects of acute progesterone administration upon responses to acute psychosocial stress in men

Animal studies suggest that neuroactive steroids, in particular progesterone and its metabolites, have stress-dampening effects. However, few studies have explored these effects in humans. In this study, we investigated the effects of acute progesterone ...

www.ncbi.nlm.nih.gov

The neurosteroid tetrahydroprogesterone attenuates the endocrine response to stress and exerts glucocorticoid-like effects on vasopressin gene transcription in the rat hypothalamus - PubMed

The neurosteroid tetrahydroprogesterone (5 alpha-pregnan-3 alpha-ol-20-one, allopregnanolone, THP), has been previously shown to counteract the anxiogenic effects of corticotropin-releasing hormone (CRH) and to interfere with noradrenergic and corticosteroid-mediated regulation of CRH release...

pubmed.ncbi.nlm.nih.gov

 

[Nicole Carter]

Thanks @haidut going for another blood test this week, it’s been 2 months since the urinalysis so I’ll keep tabs and co slider the cyproheptadine.

 

['peataphysique]

High cortisol is a known result of being on the carnivore diet for extended period of time. If several tests across say 2-3 months keep showing elevated cortisol numbers you may want to consider pharmacological interventions to lower it. Cyproheptadine seems a good choice as it has been successfully used to treat even Cushing disease. Progesterone in doses of 50mg or higher also seems to lower excess cortisol.

Effects of acute progesterone administration upon responses to acute psychosocial stress in men

Animal studies suggest that neuroactive steroids, in particular progesterone and its metabolites, have stress-dampening effects. However, few studies have explored these effects in humans. In this study, we investigated the effects of acute progesterone ...

www.ncbi.nlm.nih.gov

The neurosteroid tetrahydroprogesterone attenuates the endocrine response to stress and exerts glucocorticoid-like effects on vasopressin gene transcription in the rat hypothalamus - PubMed

The neurosteroid tetrahydroprogesterone (5 alpha-pregnan-3 alpha-ol-20-one, allopregnanolone, THP), has been previously shown to counteract the anxiogenic effects of corticotropin-releasing hormone (CRH) and to interfere with noradrenergic and corticosteroid-mediated regulation of CRH release...

pubmed.ncbi.nlm.nih.gov

If one has high cortisol and decides to try cyproheptadine, can it be used indefinitely on a daily basis or is tolerance a concern in this case? if it should be cycled then, should it be used daily for let's say a month then stop for a month, or should it be used more like 3 times per week?

 

[GelatinGoblin]

Interested aswell @haidut

 

[Ismail]

I’ve been eating Peat style for 5 months, after 2 1/2 years carnivore (used to heal colitis) but my cortisol is still extremely high as found on a 24 hour urinalysis. Could it be high from the diet? How long does it take to recover? I’m also taking 1/2 tab of cynomel daily, tocovit, ashwaganda and progesterone during Luteal phase.

@Nicole Carter did you manage to bring under control the high cortisol? If so, how did you do it? Thanks