maillol
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- Oct 28, 2019
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From this study Neuromodulation of Aerobic Exercise—A Review
Muscle activity requires uptake of branched-chain amino acids. These are normally in competition with tryptophan, the precursor of serotonin, to be carried across the blood–brain barrier. By reducing the amount of competitive amino acids through muscle uptake, aerobic exercise increases tryptophan's chances of crossing the blood–brain barrier, and so has the potential to increase serotonin in the brain (Patrick and Ames, 2015). Serotonin is an important neurotransmitter for emotional processing (Harmer, 2008) and serves memory functions in the hippocampus (Haider et al., 2006).
This suggests to me that taking BCAAs after exercise would be a good idea.
Then...
Increases in serotonin and dopamine seem to modulate fatigue upon prolonged exercise. Exhaustion appears to set in when dopamine levels start to drop while serotonin levels are still elevated (Meeusen and De Meirleir, 1995). The serotonin agonist quipazine dimaleate (acting on the 5-HT3 receptor) appears to shorten time to exhaustion and withholds the exercise-induced dopamine boost normally occurring after around 1 h of running in tested animals. The serotonin receptor antagonist LY53857 can increase time to exhaustion and prevents the dopamine decrease (Meeusen and De Meirleir, 1995). This fact may explain why runners usually take food supplements based on tyrosine, the precursor of dopamine, during endurance training, given that it could prevent the decrease of dopamine. Not surprisingly, several studies have shown that the intake of tyrosine may compensate cognitive decline associated with cognitive challenges (Colzato et al., 2014; Steenbergen et al., 2015) and stress (Deijen and Orbleke, 1994).
This LY53857 stuff sounds interesting. Does anyone know anything about it?
Muscle activity requires uptake of branched-chain amino acids. These are normally in competition with tryptophan, the precursor of serotonin, to be carried across the blood–brain barrier. By reducing the amount of competitive amino acids through muscle uptake, aerobic exercise increases tryptophan's chances of crossing the blood–brain barrier, and so has the potential to increase serotonin in the brain (Patrick and Ames, 2015). Serotonin is an important neurotransmitter for emotional processing (Harmer, 2008) and serves memory functions in the hippocampus (Haider et al., 2006).
This suggests to me that taking BCAAs after exercise would be a good idea.
Then...
Increases in serotonin and dopamine seem to modulate fatigue upon prolonged exercise. Exhaustion appears to set in when dopamine levels start to drop while serotonin levels are still elevated (Meeusen and De Meirleir, 1995). The serotonin agonist quipazine dimaleate (acting on the 5-HT3 receptor) appears to shorten time to exhaustion and withholds the exercise-induced dopamine boost normally occurring after around 1 h of running in tested animals. The serotonin receptor antagonist LY53857 can increase time to exhaustion and prevents the dopamine decrease (Meeusen and De Meirleir, 1995). This fact may explain why runners usually take food supplements based on tyrosine, the precursor of dopamine, during endurance training, given that it could prevent the decrease of dopamine. Not surprisingly, several studies have shown that the intake of tyrosine may compensate cognitive decline associated with cognitive challenges (Colzato et al., 2014; Steenbergen et al., 2015) and stress (Deijen and Orbleke, 1994).
This LY53857 stuff sounds interesting. Does anyone know anything about it?
