Exercise And Inflammatory Markers?

Logan-

Member
Joined
May 26, 2018
Messages
1,581
I have always thought exercise increases inflammatory markers, and the increase in inflammation doesn't really level off in time; but the studies I have read say the contrary. What do you think? I am asking because I have a chronic inflammatory disease and I am avoiding sports and exercise because of that.

Journal of the American College of Cardiology
Volume 45, Issue 10, 17 May 2005, Pages 1563-1569

State-of-the-Art Paper
The Effects of Physical Activity on Serum C-Reactive Protein and Inflammatory Markers: A Systematic Review

Author links open overlay panelChristosKasapisMD⁎Paul D.ThompsonMD(FACC)†
Redirecting

Conclusions
There is a short-term, transient increase in serum CRP after strenuous exercise, produced by an exercise-induced APR, mediated by the cytokine system and mainly IL-6. Exercise training may blunt this response, whereas there is also a homeostatic, anti-inflammatory counter-APR after strenuous exercise. Chronic physical activity reduces resting CRP levels by multiple mechanisms, including a decrease in cytokine production by adipose tissue, skeletal muscles, endothelial and blood mononuclear cells, improved endothelial function and insulin sensitivity, and possibly an antioxidant effect.

(APR): Acute Phase Response


**************************** ****************************

Effect of exercise training on C reactive protein: a systematic review and meta-analysis of randomised and non-randomised controlled trials
  1. Michael V Fedewa1,
  2. Elizabeth D Hathaway2,
  3. Christie L Ward-Ritacco3
Author affiliations


Abstract
Purpose C-reactive protein (CRP) is a marker of chronic systemic inflammation frequently used in cardiovascular disease risk assessment. The purpose of this meta-analysis was to provide a quantitative estimate of the magnitude of change in CRP following participation in physical exercise interventions.

Methods All studies included in the meta-analysis were peer reviewed and published in English. Human participants were assigned to a non-exercise comparison group or exercise training group, with the intervention lasting ≥2 weeks. CRP levels were measured at baseline, during and/or after completion of the exercise training programme. Random-effects models were used to aggregate a mean effect size (ES), 95% CIs and potential moderators.

Results 83 randomised and non-randomised controlled trials met the inclusion criteria and resulted in 143 effects (n=3769). The mean ES of 0.26 (95% CI 0.18 to 0.34, p<0.001) indicated a decrease in CRP following exercise training. A decrease in body mass index (BMI; β=1.20, SE=0.25, p<0.0001) and %Fat (β=0.76, SE=0.21, p=0.0002) were associated with a decrease in CRP, independently accounting for 11.1% and 6.6% of the variation in response, respectively. Exercise training led to a greater reduction in CRP when accompanied by a decrease in BMI (ES=0.38, 95% CI 0.26 to 0.50); however, a significant improvement in CRP occurred in the absence of weight loss (ES=0.19, 95% CI 0.10 to 0.28; both p<0.001).

Conclusions These results suggest that engaging in exercise training is associated with a decrease in CRP levels regardless of the age or sex of the individual; however, greater improvements in CRP level occur with a decrease in BMI or %Fat.

Effect of exercise training on C reactive protein: a systematic review and meta-analysis of randomised and non-randomised controlled trials
Fedewa MV, Hathaway ED, Ward-Ritacco CL
Effect of exercise training on C reactive protein: a systematic review and meta-analysis of randomised and non-randomised controlled trials
Br J Sports Med 2017;51:670-676.


**************************** ****************************


Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study
Timo A. Lakka Hanna-Maaria Lakka Tuomo Rankinen Arthur S. Leon D.C. Rao James S. Skinner Jack H. Wilmore Claude Bouchard
European Heart Journal, Volume 26, Issue 19, 1 October 2005, Pages 2018–2025, Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study
Published:
29 June 2005
Abstract
Purpose C-reactive protein (CRP) is a marker of chronic systemic inflammation frequently used in cardiovascular disease risk assessment. The purpose of this meta-analysis was to provide a quantitative estimate of the magnitude of change in CRP following participation in physical exercise interventions.

Methods All studies included in the meta-analysis were peer reviewed and published in English. Human participants were assigned to a non-exercise comparison group or exercise training group, with the intervention lasting ≥2 weeks. CRP levels were measured at baseline, during and/or after completion of the exercise training programme. Random-effects models were used to aggregate a mean effect size (ES), 95% CIs and potential moderators.

Results 83 randomised and non-randomised controlled trials met the inclusion criteria and resulted in 143 effects (n=3769). The mean ES of 0.26 (95% CI 0.18 to 0.34, p<0.001) indicated a decrease in CRP following exercise training. A decrease in body mass index (BMI; β=1.20, SE=0.25, p<0.0001) and %Fat (β=0.76, SE=0.21, p=0.0002) were associated with a decrease in CRP, independently accounting for 11.1% and 6.6% of the variation in response, respectively. Exercise training led to a greater reduction in CRP when accompanied by a decrease in BMI (ES=0.38, 95% CI 0.26 to 0.50); however, a significant improvement in CRP occurred in the absence of weight loss (ES=0.19, 95% CI 0.10 to 0.28; both p<0.001).

Conclusions These results suggest that engaging in exercise training is associated with a decrease in CRP levels regardless of the age or sex of the individual; however, greater improvements in CRP level occur with a decrease in BMI or %Fat.
 
Last edited:
OP
L

Logan-

Member
Joined
May 26, 2018
Messages
1,581
Med Sci Sports Exerc. 2003 Apr;35(4):575-81.
Inflammatory markers and exercise: differences related to exercise type.
King DE1, Carek P, Mainous AG 3rd, Pearson WS.
Author information
Abstract

PURPOSE:
To examine the relationship between elevated inflammatory markers (CRP, fibrinogen, and white blood cell levels) and various forms of exercise for the adult U.S. population while controlling for factors that might influence the relationship.

METHODS:
An analysis of the adults age 17 and over who participated in the National Health and Nutrition Examination Survey (NHANES) III was conducted. The main goal of the analysis was to determine whether exercise type was associated with systemic markers of inflammation. Bivariate statistics using chi-square to evaluate different types of exercise according to the presence of elevated and nonelevated inflammatory markers was initially performed. In addition, multivariate models were constructed using each type of exercise activity as the predictor variable and each inflammatory marker as the dependent variable.

RESULTS:
A total of 4072 people were included in the analysis. In bivariate analyses, compared with nonexercisers in a specific exercise type, a significant lower likelihood of elevated inflammatory markers was found among regular participants in jogging, swimming, cycling, aerobic dancing, calisthenics, and weight lifting but not for gardening. After controlling for possible confounding factors including age, race, sex, body mass index, smoking, and health status in logistic regression analysis, only regular participants in jogging and aerobic dancing remained significantly less likely to have elevated cardiovascular markers.

CONCLUSIONS:
The results of this study indicate that some forms of physical activity are associated with a lower likelihood of elevation of inflammatory markers, although we cannot exclude the possibility that differences may be due to exercise intensity or duration. Future research should be directed toward further exploration of the effects of different types of exercise activity on inflammatory markers and the role of exercise in the prevention of cardiovascular disease.
Inflammatory markers and exercise: differences related to exercise type. - PubMed - NCBI


Curr Pharm Des. 2012;18(28):4326-49.
Effects of physical exercise on inflammatory markers of atherosclerosis.
Pinto A1, Di Raimondo D, Tuttolomondo A, Buttà C, Milio G, Licata G.
Author information
Abstract

It is well established that physically fit individuals have a reduced risk of developing CVD (cardiovascular disease) and other age-related chronic disorders. Regular exercise is an established therapeutic intervention with an enormous range of benefits. Chronic low-grade systemic inflammation may be involved in atherosclerosis, diabetes and in pathogenesis of several chronic pathological conditions; recent findings confirm that physical activity induces an increase in the systemic levels of a number of cytokines and chemokines with anti-inflammatory properties. The possibility that regular physical exercise exerts anti-inflammation activity, being the interaction between contracting muscle and the other tissues and the circulating cells mediated through signals transmitted by "myokines" produced with muscle contractions. To date the list of myokines includes IL-6, IL-8, and IL-15. During muscle contractions are also released IL-1 receptor antagonis and sTNF-R, molecules that contribute to provide anti-inflammatory actions. Nevertheless discrepancies, analysis of available researches seem to confirm the efficacy of regular physical training as a nonpharmacological therapy having target chronic low-grade inflammation. Given this, physical exercise could be considerate a useful weapon against local vascular and systemic inflammation in atherosclerosis. Several mechanisms explain the positive effect of chronic exercise, nevertheless, these mechanisms do not fully enlighten all pathways by which exercise can decrease inflammation and endothelial dysfunction, and hence modulate the progression of the underlying disease progress.
Inflammatory markers and exercise: differences related to exercise type. - PubMed - NCBI
https://pdfs.semanticscholar.org/50d4/e8421f90ae4fb33f4101e7cf50a94222c931.pdf (full text, look at the table 1)
 

Similar threads

Back
Top Bottom