Thank you for sharing @Amazigh .I agree that sometimes even progest-e in large doses and thyroid and other safer options don't help when estrogen dominance is really severe. I'm glad it helped you and you did not fell any side effects :) Have you noticed how it affected your libido and body temperature? Maybe you could lower the dose to 2,5mg which can estrogen but should be overall safer.I have been taking exemestane for almost a year now. My estrogen was high (which showed up on my bloodwork), and I had been experiencing symptoms for a few years that would not resolve, even with large doses of progesterone (progest-e), vitamin e, aspirin, methelyne blue, etc. I had developed painful fibrocystic breast disease, I had so many fibroids that my uterus was the size of a 5 mo pregnancy, and my periods were so long and heavy that I also developed significant anemia. I started off with 1/2 tablet/day (12.5mg) and within a few weeks my periods had normalized and my pre-period breast tenderness stopped. Fastforward to present, my uterus is no longer right under my navel and is almost back to its normal size and the cysts in my breast are gone. I personally have not felt any side effects from the exemestane. I suspect that I may not have been clearing estrogen because of some stubborn digestive issues I was having, which I am working on. Once that is resolved, and I confirm that my lumps are all gone, I'm planning on getting off of it. In the meantime though, it's been the ONLY thing that has worked in my situation.