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Exemestane (Aromasin) Experiences?

Discussion in 'Pharmaceutical Drugs' started by dookie, Sep 19, 2016.

  1. dookie

    dookie Member

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    Anyone here who has tried Exemestane / Aromasin? Apparently in bodybuilding circles, it is the "mildest" Aromatase inhibitor (AI), with the least side-effects.

    It seems to be derived from the structure of the hormone 4-androstenedione.

    I'm thinking of trying it before I try letrozole, which apparently is the "harshest" or strongest AI.

    Any particular side-effects / effects to watch out for? What has been your experience?
     
  2. haidut

    haidut Member

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    Exemestane is basically the same in effects as DHT, androsterone, androstenedione, androstanedione, androstenetrione, etc. They are all steroid aromatase inhibitors and pretty comparable in effectiveness in about the same doses.
    Action of endogenous steroid inhibitors of brain aromatase relative to fadrozole. - PubMed - NCBI

    Keep in mind that even tiny doses of exemestane works really well and there is no need to ingest it in monster quantities like the bodybuilders do. In those circles a dose of 12.5mg is considered mild and good for every day use, but in reality exemestane works the same even in 2.5mg doses and in the low doses it has no side effects like suppression of libido. See the last study in the original post of this thread (it is about exemestane).
    Androsterone - A Potent Steroidal Aromatase Inhibitor

    So, 2.5mg for a week is all you need to lower estrogen and not get bad reactions.
     
  3. superhuman

    superhuman Member

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    @haidut so 2.5mg a day for a week is all one needs? i have 1/2 a bottle of liquid exemestane here so :D
     
  4. TheHound

    TheHound Member

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    what about exemestane vs anastrozole?
     
  5. haidut

    haidut Member

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    The study showed that 2.5mg a day achieved the same reduction in estrogen as the higher doses. So, I would use the lowest dose possible. Just like other steroids.
     
  6. haidut

    haidut Member

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    What about it?
     
  7. TheHound

    TheHound Member

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    I know exemestane is a suicide aromatase inhibitor but is one better than the other for overall health at lower doses?
     
  8. haidut

    haidut Member

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    I don't like the *zole drugs. I think they replaced the much safer older drugs based on DHT (i.e. Masteron). But everybody is different so people should use what works for them.
     
  9. OP
    dookie

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    Does that include letro-zole? Reading the studies, while exemestane seems to have least side-effects, it seems anastrozole is the most risky AI, and letrozole may be the one that has the most benefits. For example, letrozole has been shown to inhibit seizures and to improve memory (and I haven't seen studies showing this for exemestane):

    Administration of an inhibitor of estrogen biosynthesis facilitates working memory acquisition in male rats. - PubMed - NCBI

    Effects of letrozole on hippocampal and cortical catecholaminergic neurotransmitter levels, neural cell adhesion molecule expression and spatial le... - PubMed - NCBI

    Aromatase inhibition, testosterone, and seizures. - PubMed - NCBI

    Aromatase inhibitors as add-on treatment for men with epilepsy. - PubMed - NCBI

    https://www.sciencedaily.com/releases/2016/05/160510084259.htm


    What do you think haidut? Could letrozole be better than exemestane, even though its a bit more "risky"?
     
  10. furball

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    I come from bodybuilding powerlifting background. I had extreme problems dropping fat. Even 2000 calorie diets would not do it. I barely made weight at my last competition despite starving for 8 weeks. I'm 265 and capable of lifting over 800 if thats any context.

    I was chronically using AI like this to control my rampant estrogen. Obviously with learning about bioenergetics I understand why this was the case. I would feel absolutely awful on anything less than 25MG a day.

    It got to the stage where I was using letro and aromasin and just always felt watery and miserable.

    Even since Peating I had problems with it.

    However. A course if antibiotics did wonders early on. And then 4 weeks of sub 5 grams fat daily diet really kicked it on its ass.

    I've been taking Estroban as well. And will be adding 11keto Dht when the arrives. Running in my love handles and chest where prone to estrogenic fat storage.

    I would go down that route. Estroban. Low fat diet. Dhea or even Dht if you want to mess around with it.

    I just think there's so much you can do to control estrogen without drugs.
     
  11. bruschi11

    bruschi11 Member

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    Bumping this thread.... Have been on TRT for a bit with a testosterone cream. Moving to injectables most likely tomorrow.

    While I really like the idea of androsterone as my AI- will this have DHT like effects on the hair even in low doses? Say 2-5mg per day? Thinking I'd like to keep the DHT hair loss sides to an absolute minimum and would just continue with arimidex rather than androsterone/exemestane if these could lead to more DHT.

    I know DHT is awesome overall, but TRT with injections itself should give me a pretty high level I'd say in the high end of the range. Compounded T cream (T in 800 range) put me at 150% of the range for DHT (125 range 20- 75).

    I know that injections should probably get me lower on DHT as long as I don't go too high on T.
     
  12. PUTFOT

    PUTFOT Member

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    What exactly did antibiotics do?
     
  13. mujuro

    mujuro Member

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    I was using exemestane for a while at 6mg every 3rd day. I began using Pansterone on scrotum and found that it was equally effective at eliminating estrogenic symptoms and producing androgenic effects (stronger erections, desire for passionate sex, no satisfaction from masturbation, diminished anxiety). I've since stopped using exemestane.
     
  14. RKIII

    RKIII Member

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    I am pretty sure letro has the worst effect on lipids/triglycerides and is the strongest of the bunch. It will crush your estrogen levels to nothing which can be just as bad as having high levels.
     
  15. redlight

    redlight Member

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    Im taking anastrolize but might switch to letozole
     
  16. redlight

    redlight Member

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    How much testosterone and how often are you going to inject?
     
  17. RKIII

    RKIII Member

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    Try iron legions invictus. Its a TD with bloods backing it lower E2 levels. It is non steroidal and wont mess with your lipids.
     
  18. ddjd

    ddjd Member

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    Which do you prefer haidut, Arimidex or exemestane
     
  19. lampofred

    lampofred Member

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    I messed around with AIs and ended up passing out and having to go to the ER with a heart rate of over 120 and an inability to breathe. Be careful with messing around with hormones... Your body tightly regulates them and has them at certain levels for its own reasons.
     
  20. lampofred

    lampofred Member

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    Interesting observation: I notice that many followers of Peat (including my rat unfortunately) don't really regard the legality of their actions in their pursuit of better health, especially when it comes to obtaining controlled prescription medications to test on their rats.

    Bromo, Diamox, Cypro, Letro, T3, etc. My rat has amassed quite the collection.

    The personality traits that attract these rats to Peat must be the same ones that drive them to disregard all conventions and any trivial concerns of legality.
     
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