Excessive HIIT exercise causes sudden and severe decline in mitochondria function

[ReSTART]

Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers

Flockhart and colleagues investigated the dose-response relationship of exercise training and found that excessive training causes mitochondrial impairment and reduced glucose tolerance in healthy volunteers. Mitochondrial ROS production was reduced, thereby maintaining total oxidative stress...

www.cell.com

Following the week with the highest exercise load, we found a striking reduction in intrinsic mitochondrial function that coincided with a disturbance in glucose tolerance and insulin secretion. We also assessed continuous blood glucose profiles in world-class endurance athletes and found that they had impaired glucose control compared with a matched control group.

 

[Razvan]

Of course. Lactic acid is the way.

 

[Mito]

What do over-trained athletes and patients with neurodegenerative diseases have in common? Mitochondrial dysfunction​

Abstract​

Under pathological conditions and excessive stress, mitochondria may experience a severe and irreversible loss of function. Both strenuous exhaustive exercise and neurodegenerative disorders appear to share defects in mitochondrial function that may fiercely disrupt the integrity and homeostasis of the organelle, leading to perennial pathological substrates. Here, we overview similarities of mitochondrial dysfunction in two conditions and discuss possible areas of interdisciplinary collaboration and research translation between sports medicine and neurology.

What do over-trained athletes and patients with neurodegenerative diseases have in common? Mitochondrial dysfunction - PubMed

Under pathological conditions and excessive stress, mitochondria may experience a severe and irreversible loss of function. Both strenuous exhaustive exercise and neurodegenerative disorders appear to share defects in mitochondrial function that may fiercely disrupt the integrity and homeostasis...

pubmed.ncbi.nlm.nih.gov

 

[Sefton10]

"Short-term, high-intensity exercise can lead to a significant and prolonged dysfunction of the mitochondrial energy status of peripheral blood leucocytes, which is accompanied by an increased propensity for apoptosis and raised pro-inflammatory mediators."

Deleterious effects of short-term, high-intensity exercise on immune function: evidence from leucocyte mitochondrial alterations and apoptosis | British Journal of Sports Medicine