Even Mildly Excessive Body Iron Levels Increase The Risk Of Type 2 Diabetes

Peater Piper

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Here's the thesis:

http://epublications.uef.fi/pub/urn_isbn_978-952-61-2300-4/urn_isbn_978-952-61-2300-4.pdf

The following conclusions can be deduced from this population study on the role of body iron on glucose homeostasis and T2D.

1. In addition to providing a further supportive evidence base to previous studies that body iron stores predict the risk of T2D, it showed for the first time the threshold of sF at which the risk of T2D becomes marked and the sTfR range associated with the least risk of T2D. Iron depletion to overt iron deficiency does not further decrease the risk of T2D as earlier speculated. The sF reference range in men is not entirely protective against the development of T2D, rather a little below high normal appeared to be safe; hence, a rule of thumb safe range could be 30-200 µg/L of sF.

2. This study showed compelling evidence that the association between body iron and glucose homeostasis in the general population is diverse and very well dependent on the glycemic state of the population. The strength and the direction of the association between body iron and glucose metabolism is strongest among subjects in prediabetes state.

3. There is a gender difference in the prevalence and incidence of T2D, with a higher prevalence and increased risk of T2D observed in men. Body iron as assessed by sF contributes about two-fifths and one-fifth to the gender difference in T2D prevalence and incidence respectively. Gender difference exists in glucose homeostasis with men having higher markers of glucose metabolism. Body iron also explains to some extent the gender difference in glucose metabolism.
 

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