Prolactin is commonly referenced as being accurate representation of estrogen status in this forum. These studies show that this is not the case in humans and estrogenic effects don't correlate with prolactin but instead with serum estrogens.
No correlation between prolactin and estrogen+spironolactone treatment.
PROLACTIN LEVELS DO NOT RISE AMONG TRANSGENDER WOMEN TREATED WITH ESTRADIOL AND SPIRONOLACTONE. - PubMed - NCBI
GnRH agonist+estradiol treatment for male-to-female transsexuals. Several estrogenic effects like breast growth, increased SHBG and bone mineral density are observed during treatment. Significant changes in serum estradiol but not in prolactin levels.
Endocrine Treatment of Male-To-Female Transsexuals Using Gonadotropin-Releasing Hormone Agonist - PubMed
Increased estrone and estradiol from spironolactone treatment in males. No change in basal prolactin levels or TRH stimulated prolactin levels. Gynecomastia was observed in some patients.
Increased Serum Oestrone and Oestradiol Following Spironolactone Administration in Hypertensive Men - PubMed
High serum estradiol causes erectile dysfunction independently of prolactin.
Increased estradiol levels in venous occlusive disorder: a possible functional mechanism of venous leakage. - PubMed - NCBI
Estrogenic effects on various tissues can be observed without changes in prolactin. Estrogen dominance as high serum estradiol and low T:E ratio does not directly raise prolactin. For these reasons prolactin should be considered as independent marker instead of as a surrogate for estrogen levels in tissues.
No correlation between prolactin and estrogen+spironolactone treatment.
PROLACTIN LEVELS DO NOT RISE AMONG TRANSGENDER WOMEN TREATED WITH ESTRADIOL AND SPIRONOLACTONE. - PubMed - NCBI
GnRH agonist+estradiol treatment for male-to-female transsexuals. Several estrogenic effects like breast growth, increased SHBG and bone mineral density are observed during treatment. Significant changes in serum estradiol but not in prolactin levels.
Endocrine Treatment of Male-To-Female Transsexuals Using Gonadotropin-Releasing Hormone Agonist - PubMed
Increased estrone and estradiol from spironolactone treatment in males. No change in basal prolactin levels or TRH stimulated prolactin levels. Gynecomastia was observed in some patients.
Increased Serum Oestrone and Oestradiol Following Spironolactone Administration in Hypertensive Men - PubMed
High serum estradiol causes erectile dysfunction independently of prolactin.
Increased estradiol levels in venous occlusive disorder: a possible functional mechanism of venous leakage. - PubMed - NCBI
Estrogenic effects on various tissues can be observed without changes in prolactin. Estrogen dominance as high serum estradiol and low T:E ratio does not directly raise prolactin. For these reasons prolactin should be considered as independent marker instead of as a surrogate for estrogen levels in tissues.
