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Estrogen Or Anti-androgen Therapy Shrinks Brain And Destroys Grey Matter

Discussion in 'Scientific Studies' started by haidut, Oct 21, 2016.

  1. haidut

    haidut Member

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    This was a human study and one of the very few to look at steroid effects on the brain as a result of supplementation. As the study said, the results are very relevant for all women who take birth control pills or HRT. It even says that estrogen therapy is known to cause dementia later in life. So much for the "female" hormone...

    http://www.nature.com/nrendo/journal/vaop/ncurrent/full/nrendo.2016.177.html

    "... Analysis of brain structures revealed volume changes predominantly in MtF individuals, particularly in the hippocampus — a region involved in neurogenesis and neuronal plasticity. Specifically, oestradiol plus anti-androgen treatment reduced hippocampal volume in MtF individuals, which was accompanied by a global increase in ventricular structures. Moreover, reduced plasma levels of progesterone in MtF individuals correlated with reductions in grey matter structures in the right hippocampus and right caudate. Overall, the findings suggest that high doses of cross-sex hormones alter structures in the adult human brain. “Our findings are also relevant for women undergoing hormone replacement therapy and those receiving oral contraceptive treatment,” comments Lanzenberger on the wider significance of their study. “As oestrogen plus progestin therapy increases the risk of dementia in postmenopausal women aged ≥65 years, our findings of pronounced decreases in the hippocampal region in response to oestradiol and anti-androgen treatment support a neurobiological underpinning of this phenomenon.”"
     
  2. ecstatichamster

    ecstatichamster Member

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    Full review:

    The extent to which, and indeed how, exogenous hormone treatment affects brain structure and function is still a matter of debate; however, evidence is emerging that high doses of hormones induce structural alterations in the brains of adult humans.

    In a new study published in Psychoneuroendocrinology, treatment of transgender individuals with cross-sex hormones is shown to result in changes in subcortical brain areas related to memory and emotion. Rupert Lanzenberger and his team studied 14 male-to-female (MtF) and 25 female-to-male (FtM) transgender individuals.

    Participants were naive to sex hormone treatment at the start of the study and reported gender dysphoria before or at puberty. Crosssex hormones were administered in high doses: FtM individuals received testosterone whereas MtF individuals were treated with oestradiol and an anti-androgen.

    MRI examinations and plasma measurements of testosterone, oestradiol and progesterone were performed at baseline and after 4 months of continuous treatment. After the treatment period, oestradiol levels were increased in MtF individuals, whereas levels of testosterone and progesterone were decreased.

    Conversely, in FtM individuals, levels of oestradiol and progesterone were decreased, whereas testosterone levels increased markedly.

    Analysis of brain structures revealed volume changes predominantly in MtF individuals, particularly in the hippocampus — a region involved in neurogenesis and neuronal plasticity.

    Specifically, oestradiol plus anti-androgen treatment reduced hippocampal volume in MtF individuals, which was accompanied by a global increase in ventricular structures.

    Moreover, reduced plasma levels of progesterone in MtF individuals correlated with reductions in grey matter structures in the right hippocampus and right caudate.

    Overall, the findings suggest that high doses of cross-sex hormones alter structures in the adult human brain.

    “Our findings are also relevant for women undergoing
    hormonereplacement therapy and those receiving oral contraceptive treatment,” comments Lanzenberger on the wider significance of their study. “As oestrogen plus progestin therapy increases the risk of dementia in postmenopausal women aged ≥65 years, our findings of pronounced decreases in the hippocampal region in response to oestradiol and anti-androgen treatment support a neurobiological underpinning of this phenomenon.”
     
  3. ecstatichamster

    ecstatichamster Member

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    they tested estrogen + progestin, whatever that is (hahaha)...
     
  4. OP
    haidut

    haidut Member

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    These progestins have no know progesterone effect. Peat said in one of his articles that even testosterone has more progesterone properties than these synthetic toxins. I researched a few of them years ago and it seems that they are actually glucocorticoid agonists. Given that cortisol destroys the brain, I am not surprised a combination of estrogen and cortisol mimetic progestin shrank the brain. In fact, it would be hard to pick a better combination for brain destruction except possible adding an anti-androgen, which they did as well.
     
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