I've been taking 4 drops of Estroban a day plus 2 drops of retinil and 2 drops of Kuinone to try and push some estrogen out of my fat/tissue stores. I finally convinced my doc to order estrogen sulfate and prolactin tests. My prolactin is near the bottom of the range but the E1S number came back high. Is this an indication that I'm successfully getting the estrogen out and it's spiking serum levels or is high E1S and indication of general estrogen overload? My previous estradiol numbers have always come back bottom of the range.
So, E1S is an indication of high estrogenic "reserves". The body converts E1S into estrone (E1) as needed and then converts estrone to estradiol as needed. So, I would take the E1S number as more reliable than prolactin since prolactin rises together with estradiol and yours was low as you said. Having high E1S is ceratinly not desirable. Typically E1S is high in overweight people or people with low T/DHEA, or people with insulin resistance. Vitamin E, aspirin, progesterone, and even pregnenolone can lower E1S as I posted before.