LLight
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- May 30, 2018
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I don't know if it's related to your case but I find this article interesting : https://www.cell.com/cell/fulltext/S0092-8674(17)30829-2
"During dehydration, the relative sodium concentration within the renal medulla increases to facilitate water reabsorption from filtrate to concentrate urine and restore normovolaemia. This scenario produces physical conditions that are permissive for infection, with low urine flow and reduced expulsion of bacteria ascending from the bladder. Our data suggest that it is in just such conditions that the medullary defense zone is optimized. This is achieved by utilizing the same environmental signal that is required for urine concentration to position antibacterial MNPs in the medulla and to augment their function. This elegant mechanism allows local conditions to orchestrate a responsive and adaptable defense zone, commensurate with the likely challenge; when physical expulsion of bacteria is at its weakest, tissue-resident sentinels are strengthened by the local hypersalinity."
"During dehydration, the relative sodium concentration within the renal medulla increases to facilitate water reabsorption from filtrate to concentrate urine and restore normovolaemia. This scenario produces physical conditions that are permissive for infection, with low urine flow and reduced expulsion of bacteria ascending from the bladder. Our data suggest that it is in just such conditions that the medullary defense zone is optimized. This is achieved by utilizing the same environmental signal that is required for urine concentration to position antibacterial MNPs in the medulla and to augment their function. This elegant mechanism allows local conditions to orchestrate a responsive and adaptable defense zone, commensurate with the likely challenge; when physical expulsion of bacteria is at its weakest, tissue-resident sentinels are strengthened by the local hypersalinity."
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