Ergot alkaloids block stress-induced analgesia (SIA)

DaveFoster

Member
Joined
Jul 23, 2015
Messages
4,920
Location
Spokane, Washington
Effects of ergot alkaloids on stress-induced analgesia.


Abstract
Repeated, thirty minute anticipation of unavoidable painful stimulation causes endorphin-induced analgesia in rats. This type of stress-induced analgesia (SIA) develops rapidly during the first minutes of the exposure to anticipation stress. SIA can be demonstrated during the whole period of anticipation stress. Ergot drugs (DH--ergotoxine, lisuride, trans-9,10 dihydrolisuride) administered 30 min before the onset of anticipation stress, blocked completely this form of SIA. On the other hand, no effect of ergot alkaloids in the tail-flick latency, as measured under resting conditions, was observed. Possible interactions of ergot alkaloids with opiate receptors as an important mechanism by which ergot drugs affect SIA are discussed.

If I understand this correctly, certain ergot alkaloids, (such as DH-ergotoxine (hydergine) and lisuride), possess an anti-opiate effect (similar to naltroxene), which supports the opiate inhibition endorsed by Peat. Therefore, these drugs retain properties that fit with his paradigm and may help explain their physiological benefits.
 
Similar threads
Thread starter Title Forum Replies Date
N Bromocriptine Source? Or Ergot Derivative Source Cortisol, Serotonin, Histamine 0
Rachel Ergot-derived Smart Drugs Miscellaneous Health Discussions 15
biggirlkisss whats bad about alkaloids [potatoe peel] Potatoes, Sweet Potatoes, Ray Peat Potato Protein 1
joshquintanilla Found A Way To Block ALL Blue Light On IPhone Easily Light 36
ddjd Take B1 With Vitamin C - It Helps Block The Effects Of Thiaminase Ask For Help or Advice 3
debored13 What Does A Right Bundle Branch Block Mean? Ask For Help or Advice 0
P Herbs That Block GR Health 0
cinderella Herbs And Spices That Block Progesterone Diet 8
P Right Bundle Branch Block Heart, Heart Rate, Blood Pressure 4
lvysaur Aspirin Blocks COX--why Not Block Arachidonic Acid At The Source? Aspirin 4
R Supplements That Block The Release Of Stored Fatty Acids Supplements, Pharmaceutical Drugs 3
T What Would Be Effective To Block Prostaglandin Production By Thymus Gland? Ask For Help or Advice 12
M How Can I Block CRHR1 ? Cortisol, Serotonin, Histamine 0
C Carrot Oligosaccharides Block Adhesion Of Enteropathogenic Organisms Carrot Salad, Bamboo Shoots, Mushrooms 0
biggirlkisss Does Water Block Orange To Red 600-670nm? Ask For Help or Advice 2
kayumochi Both THC And CBD Are Shown To Reduce Estrogen Levels And Block Estrogen Effects Cancer 10
Mr. God of Cars How To Dietetically Block SOCS2? Metabolism 0
ecstatichamster Antihistamines - Block Choline, Stop Working, SSRI-like, Anhedonia? Pharmaceutical Drugs 10
Surfari Coffee With Every Meal - Does It Block Absorption Of Nutrients? Supplements, Pharmaceutical Drugs 2
encerent Will Orange-tinted Glasses Block Harmful Blue Lights? Ask For Help or Advice 6
johnwester130 Will Coconut Oil Block Starch Presorption ? Diet, Recipes 6
johnwester130 Which Pharma Drugs Block Estrogen And Are Peat Approved ? Supplements, Pharmaceutical Drugs 6
P Do Banks Block Transactions Such As Alldaychemist Because Of Fraud Or... Society 5
haidut Plasticisers (bpa, Dehp) Boost Pufa, Estrogen, Cortisol & Block Glucose Oxidation Scientific Studies 34
johnwester130 Saw Palmetto harms the prostate and does not block DHT Scientific Studies 0
haidut Caffeine Is A Potent Anti-estrogen; Can Block Estrogen "receptor" Completely Scientific Studies 60
J How To Block The Effects Of Lactic Acid? Health 3
cantstoppeating Those pretty lights block navigation on mobile Suggestions, Complaints, Board Glitches 5
haidut Higher levels of cholesterol in cells block viral infection Scientific Studies 5
haidut Acidifying Foods Block The Release Of Growth Hormone Acidity vs. Alkalinity 31
J Pregnenolone hormone block marijuana effects Articles & Scientific Studies 0
G PUFAs block Thyroid (Fructose, Cytochrome Oxidase) Kmud Interview: Oct.10, 2010 - Sugar II [Clipped.I 0

Similar threads

Top