Amazoniac
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People that don't use gold as currency,
milk_lover;
http://www.dtic.mil/dtic/tr/fulltext/u2/629003.pdf
According to the study, there seems to be range in which the animal can live without being stressed to compensate for extreme temperatures from the environment, whether low or high. Within that safe range, the higher you get, the metabolism should improve and the animal should be more resistant to the endotoxic insult, it peaks above room temp (30 degC in this case for mice), where the lethal dose was much higher.
In the study they also evaluated the activity of a liver enzyme and cortisone and how they interact with endotoxins.
"Note that the body temperature at 15 degC is lower than that at 5 degC, but the quantity of endotoxin is approximately 30 times greater and hence may be related to the effect."
Short-term elevation in stress hormones increases the immune reaction, it's only when it's prolongued that it supresses, right?
"At 25 degC, the temperature nearest to that normally associated with "room temperature", one notes a drop in body temperature that occurs promptly and continues for the next 1-1/2 hours with a slight rise during the final hour. This hypothermia associated with endotoxin is a well-known response for the mouse."
"The average body temperature of 8 poisoned mice was 38.10 degC and that of 10 controls was 37.90 degC. Apparently, therefore, endotoxin can cause death of mice without the changes in body temperature seen in mice at other environmental temperatures."
"..If endotoxin reaches the hypothalamnus, it does so in such small amounts that it cannot be detected. The alternative possibility is the suggestion that endotoxin per se is not the primary mediator of the effect but rather releases a substance from the cells and tissues within the animal that in turn upsets the thermoregulatory center."
"There are profound changes in energy metabolism, as suggested by the ability of certain coenzymes (6), of ATP (16), and, indeed, of aspirin (17), to protect against endotoxin."
I'm merely sharing, any question should be adressed to burtlancast.
milk_lover;
http://www.dtic.mil/dtic/tr/fulltext/u2/629003.pdf
According to the study, there seems to be range in which the animal can live without being stressed to compensate for extreme temperatures from the environment, whether low or high. Within that safe range, the higher you get, the metabolism should improve and the animal should be more resistant to the endotoxic insult, it peaks above room temp (30 degC in this case for mice), where the lethal dose was much higher.
In the study they also evaluated the activity of a liver enzyme and cortisone and how they interact with endotoxins.
"Note that the body temperature at 15 degC is lower than that at 5 degC, but the quantity of endotoxin is approximately 30 times greater and hence may be related to the effect."
Short-term elevation in stress hormones increases the immune reaction, it's only when it's prolongued that it supresses, right?
"At 25 degC, the temperature nearest to that normally associated with "room temperature", one notes a drop in body temperature that occurs promptly and continues for the next 1-1/2 hours with a slight rise during the final hour. This hypothermia associated with endotoxin is a well-known response for the mouse."
"The average body temperature of 8 poisoned mice was 38.10 degC and that of 10 controls was 37.90 degC. Apparently, therefore, endotoxin can cause death of mice without the changes in body temperature seen in mice at other environmental temperatures."
"..If endotoxin reaches the hypothalamnus, it does so in such small amounts that it cannot be detected. The alternative possibility is the suggestion that endotoxin per se is not the primary mediator of the effect but rather releases a substance from the cells and tissues within the animal that in turn upsets the thermoregulatory center."
"There are profound changes in energy metabolism, as suggested by the ability of certain coenzymes (6), of ATP (16), and, indeed, of aspirin (17), to protect against endotoxin."
I'm merely sharing, any question should be adressed to burtlancast.
