Seleniodine
Member
- Joined
- Oct 20, 2016
- Messages
- 47
Environmental Enrichment Induces Pericyte and IgA-Dependent Wound Repair and Lifespan Extension in a Colon Tumor Model
Highlights
Environmental enrichment (EE) replicates mind-body therapy by providing complex housing to laboratory animals to improve their activity levels, behavior, and social interactions. Using a Tcf4Het/+ ApcMin/+-mediated model of colon tumorigenesis, we found that EE vastly improved the survival of tumor-bearing animals, with differential effect on tumor load in male compared to female animals. Analysis of Tcf4Het/+ ApcMin/+ males showed drastically reduced expression of circulating inflammatory cytokines and induced nuclear hormone receptor (NHR) signaling, both of which are common in the wound repair process. Interestingly, EE provoked tumor wound repair resolution through revascularization, plasma cell recruitment and IgA secretion, replacement of glandular tumor structures with pericytes in a process reminiscent of scarring, and normalization of microbiota. These EE-dependent changes likely underlie the profound improvement in survival of colon-tumor-bearing Tcf4Het/+ ApcMin/+ males. Our studies highlight the exciting promise of EE in the design of future therapeutic strategies for colon cancer patients.
Article about the study on Science Daily;
https://www.sciencedaily.com/releases/2017/04/170425124900.htm
"Living in a stimulating environment has a wide range of health benefits in humans and has even been shown to fight cancer in mice, but the underlying mechanisms have been unclear. A study published April 25 in Cell Reports reveals that cognitive stimulation, social interactions, and physical activity increase lifespan in mice with colon cancer by triggering the body's wound repair response."
Highlights
- •Environmental enrichment (EE) enhances the lifespan of colon-tumor-bearing mice
- •EE activates nuclear hormone receptor signaling commonly involved in wound repair
- •EE resolves the wound repair process in tumors through IgA and pericyte activities
- •EE normalizes gut microbiota and improves microbe biodiversity
Environmental enrichment (EE) replicates mind-body therapy by providing complex housing to laboratory animals to improve their activity levels, behavior, and social interactions. Using a Tcf4Het/+ ApcMin/+-mediated model of colon tumorigenesis, we found that EE vastly improved the survival of tumor-bearing animals, with differential effect on tumor load in male compared to female animals. Analysis of Tcf4Het/+ ApcMin/+ males showed drastically reduced expression of circulating inflammatory cytokines and induced nuclear hormone receptor (NHR) signaling, both of which are common in the wound repair process. Interestingly, EE provoked tumor wound repair resolution through revascularization, plasma cell recruitment and IgA secretion, replacement of glandular tumor structures with pericytes in a process reminiscent of scarring, and normalization of microbiota. These EE-dependent changes likely underlie the profound improvement in survival of colon-tumor-bearing Tcf4Het/+ ApcMin/+ males. Our studies highlight the exciting promise of EE in the design of future therapeutic strategies for colon cancer patients.
Article about the study on Science Daily;
https://www.sciencedaily.com/releases/2017/04/170425124900.htm
"Living in a stimulating environment has a wide range of health benefits in humans and has even been shown to fight cancer in mice, but the underlying mechanisms have been unclear. A study published April 25 in Cell Reports reveals that cognitive stimulation, social interactions, and physical activity increase lifespan in mice with colon cancer by triggering the body's wound repair response."
