Tarmander
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- Apr 30, 2015
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This is an interesting article from Ken L.
Enterobacteria, Weight, Stress and CFS
This is from the study he mentions in the article An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice:
"Lipopolysaccharide endotoxin is the only known bacterial product which, when subcutaneously infused into mice in its purified form, can induce obesity and insulin resistance via an inflammation-mediated pathway. Here we show that one endotoxin-producing bacterium isolated from a morbidly obese human’s gut induced obesity and insulin resistance in germfree mice. The endotoxin-producing Enterobacter decreased in relative abundance from 35% of the volunteer’s gut bacteria to non-detectable, during which time the volunteer lost 51.4 kg of 174.8 kg initial weight and recovered from hyperglycemia and hypertension after 23 weeks on a diet of whole grains, traditional Chinese medicinal foods and prebiotics. A decreased abundance of endotoxin biosynthetic genes in the gut of the volunteer was correlated with a decreased circulating endotoxin load and alleviated inflammation. Mono-association of germfree C57BL/6J mice with strain Enterobacter cloacae B29 isolated from the volunteer’s gut induced fully developed obesity and insulin resistance on a high-fat diet but not on normal chow diet, whereas the germfree control mice on a high-fat diet did not exhibit the same disease phenotypes. The Enterobacter-induced obese mice showed increased serum endotoxin load and aggravated inflammatory conditions. The obesity-inducing capacity of this human-derived endotoxin producer in gnotobiotic mice suggests that it may causatively contribute to the development of obesity in its human host."
I am really beginning to believe that the pathway out of obesity has to do with messing around with gut bacteria until you land on the right "combo," with the risk being you move things in the wrong direction with foods like bananas.
The diet in this study was used in another study shown here: A gut microbiota-targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome
This is the best description of the diet I have found so far (from the previous study):
"We designed three ready-to-use food formulas based on whole grains, traditional Chinese medicinal (TCM) foods, and prebiotics (WTP diet). Formula No. 1 was a precooked mixture of 12 component materials from whole grains and TCM food plants that are rich in dietary fiber, including adlay (Coix lachrymal-jobi L.), oat, buckwheat, white bean, yellow corn, red bean, soybean, yam, big jujube, peanut, lotus seed, and wolfberry, which was prepared in the form of canned gruel (370 g wet weight per can) by a contract food manufacturer (Shanghai Meilin Meida Food Co., Ltd., Shanghai, China). Each can contained 100 g of ingredients (59 g carbohydrate, 15 g protein, 5 g fat, and 6 g fiber) and 336 kcal (70% carbohydrate, 17% protein, 13% fat). Formula No. 2 was a powder preparation for infusion (20 g per bag) containing bitter melon (Momordica charantia) and oligosaccharides, which included fructo-oligosaccharide and oligoisomaltose, and totally accounted for 34% of the formula No. 2. Formula No. 3 contained soluble prebiotics, including guar gum, pectin, konjac flour, other fermentable dietary fiber (Fibersol 2, resistant starch, hemicellulose), and oligosaccharides, and was administered in the form of powder for infusion (50 g per bag). The two infusion formulas were designed to facilitate the modulation of gut microbiota with a mild antibacterial effect and gas-producing function"
The diet lowered endotoxin, improved insulin resistance, etc etc
Enterobacteria, Weight, Stress and CFS
This is from the study he mentions in the article An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice:
"Lipopolysaccharide endotoxin is the only known bacterial product which, when subcutaneously infused into mice in its purified form, can induce obesity and insulin resistance via an inflammation-mediated pathway. Here we show that one endotoxin-producing bacterium isolated from a morbidly obese human’s gut induced obesity and insulin resistance in germfree mice. The endotoxin-producing Enterobacter decreased in relative abundance from 35% of the volunteer’s gut bacteria to non-detectable, during which time the volunteer lost 51.4 kg of 174.8 kg initial weight and recovered from hyperglycemia and hypertension after 23 weeks on a diet of whole grains, traditional Chinese medicinal foods and prebiotics. A decreased abundance of endotoxin biosynthetic genes in the gut of the volunteer was correlated with a decreased circulating endotoxin load and alleviated inflammation. Mono-association of germfree C57BL/6J mice with strain Enterobacter cloacae B29 isolated from the volunteer’s gut induced fully developed obesity and insulin resistance on a high-fat diet but not on normal chow diet, whereas the germfree control mice on a high-fat diet did not exhibit the same disease phenotypes. The Enterobacter-induced obese mice showed increased serum endotoxin load and aggravated inflammatory conditions. The obesity-inducing capacity of this human-derived endotoxin producer in gnotobiotic mice suggests that it may causatively contribute to the development of obesity in its human host."
I am really beginning to believe that the pathway out of obesity has to do with messing around with gut bacteria until you land on the right "combo," with the risk being you move things in the wrong direction with foods like bananas.
The diet in this study was used in another study shown here: A gut microbiota-targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome
This is the best description of the diet I have found so far (from the previous study):
"We designed three ready-to-use food formulas based on whole grains, traditional Chinese medicinal (TCM) foods, and prebiotics (WTP diet). Formula No. 1 was a precooked mixture of 12 component materials from whole grains and TCM food plants that are rich in dietary fiber, including adlay (Coix lachrymal-jobi L.), oat, buckwheat, white bean, yellow corn, red bean, soybean, yam, big jujube, peanut, lotus seed, and wolfberry, which was prepared in the form of canned gruel (370 g wet weight per can) by a contract food manufacturer (Shanghai Meilin Meida Food Co., Ltd., Shanghai, China). Each can contained 100 g of ingredients (59 g carbohydrate, 15 g protein, 5 g fat, and 6 g fiber) and 336 kcal (70% carbohydrate, 17% protein, 13% fat). Formula No. 2 was a powder preparation for infusion (20 g per bag) containing bitter melon (Momordica charantia) and oligosaccharides, which included fructo-oligosaccharide and oligoisomaltose, and totally accounted for 34% of the formula No. 2. Formula No. 3 contained soluble prebiotics, including guar gum, pectin, konjac flour, other fermentable dietary fiber (Fibersol 2, resistant starch, hemicellulose), and oligosaccharides, and was administered in the form of powder for infusion (50 g per bag). The two infusion formulas were designed to facilitate the modulation of gut microbiota with a mild antibacterial effect and gas-producing function"
The diet lowered endotoxin, improved insulin resistance, etc etc
