Enhancement of Mammary Tumorigenesis by Dietary Selenium Deficiency in Rats with a High Polyunsatura

[Entropy]

Enhancement of Mammary Tumorigenesis by Dietary Selenium Deficiency in Rats with a High Polyunsaturated Fat Intake
http://cancerres.aacrjournals.org/content/41/1/31.short

"Four basal diets deficient in selenium were used: (a) 1% corn oil; (b) 5% corn oil; (c) 25% corn oil; and (d) a high saturated fat diet containing 1% corn oil and 24% hydrogenated coconut oil."

"In animals that received an adequate supplement of selenium, an increase in fat intake was accompanied by an increased tumor incidence when corn oil was used in the diets. A high saturated fat ration, on the other hand, was much less effective in this respect. Only in those rats that were maintained on a high polyunsaturated fat diet (25% corn oil) did selenium depletion result in a further increase in tumor incidence and tumor yield. Such an augmentation was not observed in animals given either a 1 or a 5% corn oil ration or a diet rich in saturated fat."

"The antioxidant property of selenium is discussed as a possible mechanism by which selenium protects against tumorigenesis, especially in animals with a high polyunsaturated fat intake."

 

[Mauritio]

Enhancement of Mammary Tumorigenesis by Dietary Selenium Deficiency in Rats with a High Polyunsaturated Fat Intake
http://cancerres.aacrjournals.org/content/41/1/31.short

"Four basal diets deficient in selenium were used: (a) 1% corn oil; (b) 5% corn oil; (c) 25% corn oil; and (d) a high saturated fat diet containing 1% corn oil and 24% hydrogenated coconut oil."

"In animals that received an adequate supplement of selenium, an increase in fat intake was accompanied by an increased tumor incidence when corn oil was used in the diets. A high saturated fat ration, on the other hand, was much less effective in this respect. Only in those rats that were maintained on a high polyunsaturated fat diet (25% corn oil) did selenium depletion result in a further increase in tumor incidence and tumor yield. Such an augmentation was not observed in animals given either a 1 or a 5% corn oil ration or a diet rich in saturated fat."

"The antioxidant property of selenium is discussed as a possible mechanism by which selenium protects against tumorigenesis, especially in animals with a high polyunsaturated fat intake."

Great study .
Shows :
- pufa bad , leads to lipid peroxidation/ oxidative stress ,which selenium protects from
- sfa better , less oxidative stress ,less tumors