Endotoxin (TLR4) Linked To Earlier COPD

raypeatclips

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Association between TLR2/TLR4 gene polymorphisms and COPD phenotype in a Greek cohort. - PubMed - NCBI

In a cohort of 114 Greek COPD patients, we confirmed that the presence of TLR4-D299G or TLR4-T399I SNPs was significantly associated with an earlier COPD stage (p = 0.003 and p = 0.009, respectively). In comparison, the absence of any analyzed polymorphism, including those of TLR2-R753Q and genotypic MBL deficiency, was significantly associated with a more severe disease phenotype, characterized by more frequent exacerbations (p = 0.045).
 

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